We are interested in the structure and function of the eukaryotic splicing machine: the spliceosome. We have solved a number of crystal and NMR structures of spliceosome components, and more recently have elucidated high resolution cryo-EM structures of the entire spliceosome at different stages of catalysis. These structures provide a framework for dissecting the mechanism of pre-mRNA splicing.
An ERC funded position is available to work on the structure and function of yeast and mammalian spliceosomes. More information is available here