We are interested in the structure and function of the eukaryotic splicing machine: the spliceosome. We have solved a number of crystal and NMR structures of spliceosome components, and more recently have elucidated high resolution cryo-EM structures of the entire spliceosome at different stages of catalysis. These structures provide a framework for dissecting the mechanism of pre-mRNA splicing.
Kiyoshi Nagai (1949 – 2019)
We recently lost our mentor, sensei, friend, and inspiration. Chris Oubridge has written an obituary for Kiyoshi which can be found here