2025
- Ghanim, G.E., Hu, H., Boulanger, J., Nguyen, T.H.D. (2025)
Structural mechanism of LINE-1 target-primed reverse transcription.
Science 388(6745): eads8412 - Sekne, Z., Ludzia, P., Balch, S., Nguyen, T.H.D. (2025)
Structural Biology of Telomerase and Associated Factors.
Cold Spring Harb Perspect Biol [Epub ahead of print] - Bu, F., Adam, Y., Adamiak, R.W., Antczak, M., de Aquino, B.R.H., Badepally, N.G., Batey, R.T., Baulin, E.F., Boinski, P., Boniecki, M.J., Bujnicki, J.M., Carpenter, K.A., Chacon, J., Chen, S.J., Chiu, W., Cordero, P., Das, N.K., Das, R., Dawson, W.K., DiMaio, F., Ding, F., Dock-Bregeon, A.C., Dokholyan, N.V., Dror, R.O., Dunin-Horkawicz, S., Eismann, S., Ennifar, E., Esmaeeli, R., Farsani, M.A., Ferré-D'Amaré, A.R., Geniesse, C., Ghanim, G.E., Guzman, H.V., Hood, I.V., Huang, L., Jain, D.S., Jaryani, F., Jin, L., Joshi, A., Karelina, M., Kieft, J.S., Kladwang, W., Kmiecik, S., Koirala, D., Kollmann, M., Kretsch, R.C., Kurciński, M., Li, J., Li, S., Magnus, M., Masquida, B., Moafinejad, S.N., Mondal, A., Mukherjee, S., Nguyen, T.H.D., Nikolaev, G., Nithin, C., Nye, G., Pandaranadar Jeyeram, I.P.N., Perez, A., Pham, P., Piccirilli, J.A., Pilla, S.P., Pluta, R., Poblete, S., Ponce-Salvatierra, A., Popenda, M., Popenda, L., Pucci, F., Rangan, R., Ray, A., Ren, A., Sarzynska, J., Sha, C.M., Stefaniak, F., Su, Z., Suddala, K.C., Szachniuk, M., Townshend, R., Trachman, R.J., Wang, J., Wang, W., Watkins, A., Wirecki, T.K., Xiao, Y., Xiong, P., Xiong, Y., Yang, J., Yesselman, J.D., Zhang, J., Zhang, Y., Zhang, Z., Zhou, Y., Zok, T., Zhang, D., Zhang, S., Żyła, A., Westhof, E., Miao, Z. (2025)
RNA-Puzzles Round V: blind predictions of 23 RNA structures.
Nat Methods 22(2): 399-411
2024
- Hu, H., Yan, H.L., Nguyen, T.H.D. (2024)
Structural biology of shelterin and telomeric chromatin: the pieces and an unfinished puzzle.
Biochem Soc Trans 52(4): 1551-1564 - Ghanim, G.E., Sekne, Z., Balch, S., van Roon, A.M., Nguyen, T.H.D. (2024)
2.7 Å cryo-EM structure of human telomerase H/ACA ribonucleoprotein.
Nat Commun 15(1): 746
2023
- Hu, H., van Roon, A.M., Ghanim, G.E., Ahsan, B., Oluwole, A.O., Peak-Chew, S.Y., Robinson, C.V., Nguyen, T.H.D. (2023)
Structural basis of telomeric nucleosome recognition by shelterin factor TRF1.
Sci Adv 9(34): eadi4148 - Healy, M.D., McNally, K.E., Butkovič, R., Chilton, M., Kato, K., Sacharz, J., McConville, C., Moody, E.R.R., Shaw, S., Planelles-Herrero, V.J., Yadav, S.K.N., Ross, J., Borucu, U., Palmer, C.S., Chen, K.E., Croll, T.I., Hall, R.J., Caruana, N.J., Ghai, R., Nguyen, T.H.D., Heesom, K.J., Saitoh, S., Berger, I., Schaffitzel, C., Williams, T.A., Stroud, D.A., Derivery, E., Collins, B.M., Cullen, P.J. (2023)
Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome.
Cell 186(10): 2219-2237.e29
2022
- Sekne, Z., Ghanim, G.E., van Roon, A.M., Nguyen, T.H.D. (2022)
Structural basis of human telomerase recruitment by TPP1-POT1.
Science 375(6585): 1173-1176
2021
- Nguyen, T.H.D. (2021)
Structural biology of human telomerase: progress and prospects.
Biochem Soc Trans 49(5): 1927-1939 - Ghanim, G.E., Fountain, A.J., van Roon, A.M., Rangan, R., Das, R., Collins, K., Nguyen, T.H.D. (2021)
Structure of human telomerase holoenzyme with bound telomeric DNA.
Nature 593(7859): 449-453
2019
- Nguyen, T.H.D., Collins, K., Nogales, E. (2019)
Telomerase structures and regulation: shedding light on the chromosome end.
Curr Opin Struct Biol 55: 185-193
2018
- Nguyen, T.H.D., Tam, J., Wu, R.A., Greber, B.J., Toso, D., Nogales, E., Collins, K. (2018)
Cryo-EM structure of substrate-bound human telomerase holoenzyme.
Nature 557(7704): 190-195
2017
- Greber, B.J., Nguyen, T.H.D., Fang, J., Afonine, P.V., Adams, P.D., Nogales, E. (2017)
The cryo-electron microscopy structure of human transcription factor IIH.
Nature 549(7672): 414-417 - Han, Y., Yan, C., Nguyen, T.H.D., Jackobel, A.J., Ivanov, I., Knutson, B.A., He, Y. (2017)
Structural mechanism of ATP-independent transcription initiation by RNA polymerase I.
Elife 6
2016
- Nguyen, T.H., Galej, W.P., Fica, S.M., Lin, P.C., Newman, A.J., Nagai, K. (2016)
CryoEM structures of two spliceosomal complexes: starter and dessert at the spliceosome feast.
Curr Opin Struct Biol 36: 48-57 - Nguyen, T.H.D., Galej, W.P., Bai, X.C., Oubridge, C., Newman, A.J., Scheres, S.H.W., Nagai, K. (2016)
Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution.
Nature 530(7590): 298-302
2015
- Nguyen, T.H., Galej, W.P., Bai, X.C., Savva, C.G., Newman, A.J., Scheres, S.H., Nagai, K. (2015)
The architecture of the spliceosomal U4/U6.U5 tri-snRNP.
Nature 523(7558): 47-52
2014
- Galej, W.P., Nguyen, T.H., Newman, A.J., Nagai, K. (2014)
Structural studies of the spliceosome: zooming into the heart of the machine.
Curr Opin Struct Biol 25(100): 57-66
2013
- Nguyen, T.H., Li, J., Galej, W.P., Oshikane, H., Newman, A.J., Nagai, K. (2013)
Structural basis of Brr2-Prp8 interactions and implications for U5 snRNP biogenesis and the spliceosome active site.
Structure 21(6): 910-19
2011
- de la Cruz, L., Nguyen, T.H., Ozawa, K., Shin, J., Graham, B., Huber, T., Otting, G. (2011)
Binding of low molecular weight inhibitors promotes large conformational changes in the dengue virus NS2B-NS3 protease: fold analysis by pseudocontact shifts.
J Am Chem Soc 133(47): 19205-15 - Nguyen, T.H., Ozawa, K., Stanton-Cook, M., Barrow, R., Huber, T., Otting, G. (2011)
Generation of pseudocontact shifts in protein NMR spectra with a genetically encoded cobalt(II)-binding amino acid.
Angew Chem Int Ed Engl 50(3): 692-4
2008
- Hadler, K.S., Tanifum, E.A., Yip, S.H., Mitić, N., Guddat, L.W., Jackson, C.J., Gahan, L.R., Nguyen, K., Carr, P.D., Ollis, D.L., Hengge, A.C., Larrabee, J.A., Schenk, G. (2008)
Substrate-promoted formation of a catalytically competent binuclear center and regulation of reactivity in a glycerophosphodiesterase from Enterobacter aerogenes.
J Am Chem Soc 130(43): 14129-38