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Recent publications

https://scholar.google.com/citations?user=MNYjttUAAAAJ&hl=en

https://www.researchgate.net/profile/Philipp_Holliger

  1. Houlihan G , Arangundy-Franklin S, Porebski BT, Subramanian N, Taylor AI & Holliger P. (2020) Discovery and evolution of RNA and XNA reverse transcriptase function and fidelity. Nature Chemistry,  12 : 683–690 (cited by 17)
    Shows a method for engineering reverse transcriptase function and fidelity.
  2. Arangundy-Franklin S, Taylor AI, Porebski BT, Genna V, Peak-Chew S, Vaisman A, Woodgate R, Orozco M & Holliger P. (2019). A synthetic genetic polymer with an uncharged backbone chemistry based on alkyl phosphonate nucleic acids. Nature Chemistry 11 : 533-42 (cited by 38)
    First demonstration of the synthesis and evolution of an uncharged genetic polymer challenging the paradigm of a polyelectrolyte backbone for genetic materials.
  3. Attwater J, Raguram A, Morgunov AS, Gianni E & Holliger P (2018). Ribozyme-catalysed RNA synthesis using triplet building blocks. eLife 7: e35255. (cited by 62) Shows that triplets can overcome RNA secondary structures enabling sequence-general RNA replication.
  4. Mutschler H, Taylor AI, Porebski BT, Lightowlers A, Houlihan G, Abramov M, Herdewijn P & Holliger P (2018) Random-sequence genetic oligomer pools display an innate potential for ligation and recombination. eLife 7: e43022. (cited by 27)
    Shows innate potential for spontaneous recombination in RNA oligomer pools.
  5. Tagami S, Attwater J & Holliger P. (2017) Simple peptides derived from the ribosomal core potentiate RNA polymerase ribozyme function. Nature Chemistry 9: 325-32 (cited by 47)
    Shows that simple cationic peptides can augment RNA polymerase ribozyme function.
  6. Mutschler H, Wochner A & Holliger P. (2015) Freeze-thaw cycles as drivers of complex ribozyme assembly. Nature Chemistry 7 : 502-8. (cited by 93)
    Shows that freeze-thaw cycles can act akin to RNA chaperones.
  7. Taylor AI, Pinheiro VB, Smola MJ, Morgunov AS, Peak-Chew SY, Cozens C, Weeks KM, Herdewijn P & Holliger P. (2015) Catalysts from synthetic genetic polymers. Nature 518 : 427-30. (cited by 213). Describes the first all XNA catalysts (XNAzymes).
  8. Attwater J, Wochner A & Holliger P. (2013) In-ice evolution of RNA polymerase ribozyme activity. Nature Chemistry 5 :1011-8. (cited by 234)
    Describes the first ribozyme that can synthesize RNAs longer than itself.
  9. Pinheiro VB, Taylor AI, Cozens C, Abramov M, Renders M, Zhang S, Chaput JC, Wengel J, Peak-Chew SY, McLaughlin SH, Herdewijn P & Holliger P. (2012) Synthetic genetic polymers capable of heredity and evolution. Science 336: 341-4.  (cited by 616).
    Describes the engineering of polymerases for the synthesis and replication of xeno-nucleic acids (XNAs) as well as the evolution of the first all XNA ligands (XNA aptamers).
  10. Wochner A, Attwater J, Coulson A & Holliger P. (2011) Ribozyme-catalyzed transcription of an active ribozyme. Science 332 : 209-12. (cited by 368).
    Describes the first polymerase ribozyme able to transcribe another active ribozyme.