Houlihan G , Arangundy-Franklin S, Porebski BT, Subramanian N, Taylor AI & Holliger P. (2020)
Discovery and evolution of RNA and XNA reverse transcriptase function and fidelity.
Nature Chemistry, 12 : 683–690 (cited by 17)
Shows a method for engineering reverse transcriptase function and fidelity.
First demonstration of the synthesis and evolution of an uncharged genetic polymer challenging the paradigm of a polyelectrolyte backbone for genetic materials.
Attwater J, Raguram A, Morgunov AS, Gianni E & Holliger P (2018).
Ribozyme-catalysed RNA synthesis using triplet building blocks.
eLife7: e35255. (cited by 62)
Shows that triplets can overcome RNA secondary structures enabling sequence-general RNA replication.
Shows that freeze-thaw cycles can act akin to RNA chaperones.
Taylor AI, Pinheiro VB, Smola MJ, Morgunov AS, Peak-Chew SY, Cozens C, Weeks KM, Herdewijn P & Holliger P. (2015)
Catalysts from synthetic genetic polymers.
Nature518 : 427-30. (cited by 213).
Describes the first all XNA catalysts (XNAzymes).
Describes the first ribozyme that can synthesize RNAs longer than itself.
Pinheiro VB, Taylor AI, Cozens C, Abramov M, Renders M, Zhang S, Chaput JC, Wengel J, Peak-Chew SY, McLaughlin SH, Herdewijn P & Holliger P. (2012)
Synthetic genetic polymers capable of heredity and evolution.
Science336: 341-4. (cited by 616).
Describes the engineering of polymerases for the synthesis and replication of xeno-nucleic acids (XNAs) as well as the evolution of the first all XNA ligands (XNA aptamers).