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Bullock Lab

cytoplasmic mRNA transport

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    • Simon Bullock
    • Mark McClintock
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Our primary goal is to shed light on how cellular components are sorted and dispersed by microtubule-based motor complexes, and how these transport processes contribute to the functions of cells in situ (i.e. within organisms). We have long-standing interests in the cytoplasmic transport of  mRNAs – a process that spatially controls protein function in cells – and neuronal cargo trafficking. We use a combination of techniques, including Drosophila genetics, time-lapse microscopy, biochemistry, structural biology and single molecule assays of cargo transport in vitro. Read more about our research here.

 

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David’s paper on disease-associated and serendipitous dynein mutations is published

July 2024

Wong’s paper describing a genome-wide screen for dynein regulators in human cells is published!

February 2024

Our work on motor regulation in dynein- and kinesin-bound RNPs is published!

January 2024

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