Recent publications and preprints:
Salvador-Garcia D, Jin L, Hensley A, Gölcük M, Gallaud E, Chaaban S, Port F, Vagnoni A, Planelles-Herrero VJ, McClintock MA, Derivery E, Carter AP, Giet R, Gür M, Yildiz A and Bullock SL (2024) A force-sensitive mutation reveals a non-canonical role for dynein in anaphase progression. J Cell Biol, 223 (10): e202310022. Pubmed.
Wong CH, Wingett SW, Qian C, Hunter M, Taliaferro JM, Ross-Thriepland D** and Bullock SL** (2024) Genome-scale requirements for dynein-based transport revealed by a high-content arrayed CRISPR screen. J Cell Biol, 223 (5): e202306048. Pubmed
Heber S*, McClintock MA*, Simon B, Mehtab E, Lapouge K, Hennig J, Bullock SL** and Ephrussi A** (2024) Tropomyosin 1-I/C co-ordinates kinesin-1 and dynein motors during oskar mRNA transport. Nat Struct Mol Biol. doi: 10.1038/s41594-024-01212-x. Pubmed
Madan V, Albacete Albacete L*, Jin L*, Scaturro P, Watson JL, Muschalik N, Begum F, Boulanger J, Bauer K, Kiebler MA, Derivery E and Bullock SL (2023) HEATR5B associates with dynein-dynactin and promotes motility of endosomal membranes. EMBO J, 42: e114473. Pubmed
Gaspar I**, Phea LJ, McClintock MA, Heber S, Bullock SL** and Ephrussi A** (2023) An RNA-based feed-forward loop ensures motor switching in oskar mRNA transport. J Cell Biol 10.1083/jcb.202301113. Pubmed
Fumagalli L*, Young FL*, Boeynaems S*, De Decker M, Mehta AR, Swijsen A, Fazal R, Guo W, Moisse M, Beckers J, Dedeene L, Selvaraj BT, Vandoorne T, Madan V, van Blitterswijk M, Raitcheva D, McCampbell A, Poesen K, Gitler AD, Koch P, Vanden Berghe P, Thal DR, Verfaillie C, Chandran S, Van Den Bosch L, Bullock SL**, Van Damme P** (2021) C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility. Science Advances. doi/10.1126/sciadv.abg3013 Pubmed
Vincent J**, Preston M, Mouchet E, Laugier N, Corrigan A, Boulanger J, Brown DG, Clark R, Wigglesworth M, Carter AP and Bullock SL** (2020) A High-Throughput Cellular Screening Assay for Small-Molecule Inhibitors and Activators of Cytoplasmic Dynein-1-Based Cargo Transport. SLAS Discovery. doi: 10.1177/2472555220920581. Pubmed
Elshenawy MM, Kusakci E, Volz S, Baumbach J, Bullock SL, Yildiz A (2020) Lis1 activates dynein motility by modulating its pairing with dynactin. Nat Cell Biol. 22(5):570-578. doi: 10.1038/s41556-020-0501-4. Epub 2020 Apr 27. Pubmed
McClintock MA, Dix CI, Johnson CM, McLaughlin SH, Maizels RJ, Hoang HT and Bullock SL (2018) RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs. eLife. 2018 Jun 26;7. pii: e36312. doi: 10.7554/eLife.36312. Pubmed
Vagnoni A** and Bullock SL** (2018) A cAMP/PKA/kinesin-1 axis promotes the axonal transport of mitochondria in aging Drosophila neurons. Curr Biol., 28: 1265-1272. Pubmed
Baumbach J, Murthy A*, McClintock MA*, Dix, CI, Zalyte, R, Hoang, HT, Bullock, SL (2017) Lissencephaly-1 is a context-dependent regulator of the human dynein complex. eLife, 6: e21768. doi: 10.7554/eLife.21768. Pubmed
Mofatteh M and Bullock SL (2017) Subcellular mRNA localization. Cell, 169:178-178 (SnapShot). Pubmed
Hoang HT, Schlager MA, Carter AP and Bullock SL (2017) DYNC1H1 mutations associated with neurological diseases compromise processivity of dynein-dynactin-cargo adaptor complexes. PNAS, 114: E1597-E1606. Pubmed
Port F** and Bullock SL** (2016) Augmenting CRISPR applications in Drosophila with tRNA-flanked sgRNAs. Nat Methods, doi:10.1038/nmeth.3972. PDF
Vagnoni A** and Bullock SL** (2016) A simple method for imaging axonal transport in aging neurons using the adult Drosophila wing. Nat Protocols, 11(9): 1711-1723. PDF.
Vagnoni A, Hoffmann P and Bullock S.L. (2016) Reducing Lissencephaly-1 levels augments mitochondrial transport and has a protective effect in adult Drosophila neurons. J Cell Sci, doi: 10.1242/jcs.179184. Pubmed
Port F*(**), Muschalik N* and Bullock SL** (2015) Systematic evaluation of Drosophila CRISPR tools reveals safe and efficient alternatives to autonomous gene drives in basic research. G3, 5(7):1493-1502. Pubmed
Rossor AM, Oates EC, Salter HK, Liu Y, Murphy SM, Schule R, Gonzalez MA, Scoto M, Phadke R, Sewry CA, Houlden H, Jordanova A, Tournev I, Chamova T, Litvinenko I, Zuchner S, Herrmann DN, Blake J, Sowden JE, Acsadi G, Rodriguez ML, Menezes MP, Clarke NF, Auer Grumbach M, Bullock SL, Muntoni F, Reilly MM, North KN (2015) Phenotypic and molecular insights into spinal muscular atrophy due to mutations in BICD2. Brain, 138 (Pt2):293-310. Pubmed
Port F**, Chen HM, Lee T, Bullock SL** (2014) Optimized CRISPR/Cas tools for efficient germline and somatic genome engineering in Drosophila. PNAS, 111(29):E2967-76. doi: 10.1073/pnas.1405500111. Pubmed
Schlager MA*, Hoang HT*, Urnavicius L, Bullock SL**, Carter AP**. (2014) In vitro reconstitution of a highly processive recombinant human dynein complex. EMBO J, 33(17):1855-1868. doi: 10.15252/embj.201488792.Pubmed
Soundararajan HC and Bullock SL (2014) The influence of dynein processivity control, MAPs, and microtubule ends on directional movement of a localising mRNA. eLife., e01596. doi: 10.7554/eLife.01596. Pubmed
Dix CI, Soundararajan HC, Dzhindzhev NS, Begum F, Suter B, Ohkura H, Stephens E and Bullock SL (2013) Lissencephaly-1 promotes the recruitment of dynein and dynactin to transported mRNAs. J Cell Biol. 202(3): 479-494 Pubmed
Liu Y*, Salter HK*, Holding AN, Johnson CM, Lukavsky PJ, Walshaw J and Bullock SL (2013) Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to coordinate recruitment of cargos to dynein.Genes Dev, 27: 1233-1246 Pubmed
Amrute-Nayak M and Bullock SL (2012) Single-molecule assays reveal that RNA localization signals regulate dynein/dynactin copy number on individual transcript cargoes. Nat Cell Biol, 14(4):416-423. Pubmed
Bianco A, Dienstbier M, Salter HK, Gatto G and Bullock SL (2010) Bicaudal-D regulates FMRP levels, motility, and function during neuronal morphogenesis. Curr Biol, 20: 1487-1492. Pubmed
Bullock SL*, Ringel I*, Ish-Horowicz D and Lukavsky PJ*. (2010) A’-form RNA helices are required for cytoplasmic mRNA transport in Drosophila. Nat Struct Mol Biol, 17: 703-709. Pubmed
Li X, Kuromi H, Briggs L, Green DB, Rocha JJ, Sweeney ST and Bullock SL (2010) Bicaudal-D binds clathrin heavy chain to promotes its transport and augments synaptic vesicle recycling. EMBO J, 29: 992-1006. Pubmed
Navarro C., Bullock S and Lehmann R. (2009). Altered dynein-dependent transport in piRNA pathway mutants.PNAS, 106: 9691-9696. Pubmed
Dienstbier M, Boehl F., Li X and Bullock SL (2009). Egalitarian is a selective RNA-binding protein linking mRNA localization signals to the dynein motor. Genes Dev, 23: 1546-1558. Pubmed
Review:
Holt, CE and Bullock, SL (2009) Subcellular mRNA localization in animal cells and why it matters. Science, 326: 1212-1216 Pubmed
Policy Forum:
Akbari BO, Bellen HJ, Bier E, Bullock SL, Burt A, Church GM, Cook KR, Duchek P, Edwards OR, Esvelt K, Gantz VM, Golic KG, Gratz SJ, Harrison MM, Hayes KR, James AA, Kaufman TC, Knoblich J, Malik HS, Matthews KA, O’Connor-Giles KM, Parks AL, Perrimon N, Port F, Russell S, Ueda R, Wildonger J (2015) Biosafety: Safeguarding gene drive experiments in the laboratory. Science, 349(6241):927-9 Pubmed
* These authors contributed equally
** Co-corresponding authors
See full publication list here.