Our interest is in developing new tools to understand nuclear structural organisation in four dimensions. With the support of the mechanical and electronic workshop and of collaborators, we aim to couple cell biology and structural methods to investigate biological phenomena in vivo. The final goal is to integrate data at different scales and resolutions to model nuclear remodelling processes. Here the main methods used in the lab:
- Electron cryo Tomography / Electron cryo microscopy
- Correlative Light and Electron Microscopy
- High-resolution image processing
- Light microscopy
- Integrative structural biology
- Biochemistry
- Cell biology
- Molecular modelling
- Biophysical methods
