The “cell” is the simplest living homeostatic unity with complex characteristics: identity, evolution, time, memory, communication, resilience. In general terms the cell can be thought as a simplified molecular ecosystem, where complex living behaviours arise from the interplay between organic and physicochemical elements, many of which comes from the external environment.
Our lab searches for the ruling biophysical and structural principles which allow cellular life with a focus on the architecture of the nucleus, the main membrane compartment which transduce information. We aim to answer to this question: how does compartment morphology and functionality emerge from macromolecules organisation?
We carry out both blue-sky and biomedicine research projects on the macromolecular basis of nuclear remodelling and we develop new tools/methods to reach such goals.
We work as an interdisciplinary and collaborative team of scientists who combines in vivo and in vitro methods using an integrative structural biology approach.