The “cell” is the simplest living homeostatic unity with complex characteristics: identity, evolution, time, memory, communication, resilience. In general terms the cell can be thought as a simplified molecular ecosystem, where complex living behaviours arise from the interplay between organic and mechano-chemical elements, many of which comes from the environmental context.
Our lab searches for the ruling biophysical and chemical principles which allow cellular life with a focus on the architecture of the nucleus, the main membrane compartment which transduce information. We aim to answer to this question: how does compartment shape and function emerge from macromolecules organisation according to physiological/environmental changes?
We carry out both blue-sky and biomedicine research projects on the macromolecular basis of nuclear shape, architecture and remodelling and we develop new tools/methods to reach such goals. We use mainly an in-cell structural biology approach.
We work as an interdisciplinary and collaborative team of scientists whose goal is to produce high-quality research results.
