The “cell” is the simplest living homeostatic unity with complex characteristics: identity, evolution, time, memory, communication, resilience. In general terms the cell can be thought as a simplified molecular ecosystem, where complex living behaviours arise from the interplay between organic and mechano-chemical elements, many of which comes from the environmental context.
Our lab searches for the ruling biophysical and chemical principles which allow cellular life with a focus on the architecture of the nucleus, the main membrane compartment which transduce information. We aim to answer to this question: how does compartment function emerge from macromolecules organisation and mechanical changes?
We carry out both blue-sky and biomedicine research projects on the macromolecular basis of nuclear remodelling and we develop new tools/methods to reach such goals.
We work as an interdisciplinary and collaborative team of scientists who combines in vivo and in vitro methods using an integrative structural biology approach.
