2023
- Scheres, S.H.W., Ryskeldi-Falcon, B., Goedert, M. (2023)
Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids.
Nature 621(7980): 701-710 - Arseni, D., et al. (2023)
TDP-43 forms amyloid filaments with a distinct fold in type A FTLD-TDP.
Nature 620(7975): 898-903 - Fowler, S.L., et al. (2023)
Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease.
bioRxiv [Epub ahead of print] - Qi, C., et al. (2023)
Tau Filaments from Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC) adopt the CTE Fold.
bioRxiv [Epub ahead of print]
2022
- Schweighauser, M., et al. (2022)
Age-dependent formation of TMEM106B amyloid filaments in human brains.
Nature 605(7909): 310-314 - Yang, Y., et al. (2022)
Cryo-EM structures of amyloid-β 42 filaments from human brains.
Science 375(6577): 167-172 - Arseni, D., Hasegawa, M., Murzin, A.G., Kametani, F., Arai, M., Yoshida, M., Ryskeldi-Falcon, B. (2022)
Structure of pathological TDP-43 filaments from ALS with FTLD.
Nature 601(7891): 139-143
2021
- Shi, Y., et al. (2021)
Structure-based classification of tauopathies.
Nature 598(7880): 359-363 - Shi, Y., et al. (2021)
Correction to: Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607.
Acta Neuropathol 141(6): 983 - Shi, Y., et al. (2021)
Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607.
Acta Neuropathol 141(5): 697-708 - Goedert, M., et al. (2021)
Tau Protein and Frontotemporal Dementias.
Adv Exp Med Biol 1281: 177-199
2020
- Scheres, S.H., Zhang, W., Falcon, B., Goedert, M. (2020)
Cryo-EM structures of tau filaments.
Curr Opin Struct Biol 64: 17-25 - Zhang, W., et al. (2020)
Novel tau filament fold in corticobasal degeneration.
Nature 580(7802): 283-287
2019
- Falcon, B., et al. (2019)
Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules.
Nature 568(7752): 420-423 - Zhang, W., Falcon, B., Murzin, A.G., Fan, J., Crowther, R.A., Goedert, M., Scheres, S.H. (2019)
Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases.
Elife 8
2018
- Falcon, B., et al. (2018)
Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold.
Acta Neuropathol 136(5): 699-708 - Falcon, B., et al. (2018)
Structures of filaments from Pick's disease reveal a novel tau protein fold.
Nature 561(7721): 137-140 - Kundel, F., et al. (2018)
Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading.
ACS Chem Neurosci 9(6): 1276-1282 - Goedert, M., Falcon, B., Zhang, W., Ghetti, B., Scheres, S.H.W. (2018)
Distinct Conformers of Assembled Tau in Alzheimer's and Pick's Diseases.
Cold Spring Harb Symp Quant Biol 83: 163-171 - Falcon, B., Noad, J., McMahon, H., Randow, F., Goedert, M. (2018)
Galectin-8-mediated selective autophagy protects against seeded tau aggregation.
J Biol Chem 293(7): 2438-2451
2017
- Fitzpatrick, A.W.P., et al. (2017)
Cryo-EM structures of tau filaments from Alzheimer's disease.
Nature 547(7662): 185-190 - Goedert, M., Masuda-Suzukake, M., Falcon, B. (2017)
Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration.
Brain 140(2): 266-278 - McEwan, W.A., Falcon, B., Vaysburd, M., Clift, D., Oblak, A.L., Ghetti, B., Goedert, M., James, L.C. (2017)
Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation.
Proc Natl Acad Sci U S A 114(3): 574-579
2016
- Jackson, S.J., et al. (2016)
Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau.
J Neurosci 36(3): 762-72
2015
- Falcon, B., et al. (2015)
Conformation determines the seeding potencies of native and recombinant Tau aggregates.
J Biol Chem 290(2): 1049-65