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Publications

  • 2025
  • 2024
  • 2023
  • 2022
  • 2021
  • 2020
  • 2019
  • 2018
  • 2017
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  • 2015

2025

  • Fowler, S.L., et al. (2025)
    Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease.
    Nat Neurosci 28(1): 40-48

2024

  • Arseni, D., et al. (2024)
    Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP type C.
    Nature 634(8034): 662-668
  • Arseni, D., et al. (2024)
    Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP Type C.
    bioRxiv [Epub ahead of print]
  • Tetter, S., et al. (2024)
    TAF15 amyloid filaments in frontotemporal lobar degeneration.
    Nature 625(7994): 345-351

2023

  • Qi, C., et al. (2023)
    Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold.
    Proc Natl Acad Sci U S A 120(51): e2306767120
  • Scheres, S.H.W., Ryskeldi-Falcon, B., Goedert, M. (2023)
    Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids.
    Nature 621(7980): 701-710
  • Arseni, D., et al. (2023)
    TDP-43 forms amyloid filaments with a distinct fold in type A FTLD-TDP.
    Nature 620(7975): 898-903
  • Fowler, S.L., et al. (2023)
    Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease.
    bioRxiv [Epub ahead of print]
  • Qi, C., et al. (2023)
    Tau Filaments from Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC) adopt the CTE Fold.
    bioRxiv [Epub ahead of print]

2022

  • Schweighauser, M., et al. (2022)
    Age-dependent formation of TMEM106B amyloid filaments in human brains.
    Nature 605(7909): 310-314
  • Yang, Y., et al. (2022)
    Cryo-EM structures of amyloid-β 42 filaments from human brains.
    Science 375(6577): 167-172
  • Arseni, D., Hasegawa, M., Murzin, A.G., Kametani, F., Arai, M., Yoshida, M., Ryskeldi-Falcon, B. (2022)
    Structure of pathological TDP-43 filaments from ALS with FTLD.
    Nature 601(7891): 139-143

2021

  • Shi, Y., et al. (2021)
    Structure-based classification of tauopathies.
    Nature 598(7880): 359-363
  • Shi, Y., et al. (2021)
    Correction to: Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607.
    Acta Neuropathol 141(6): 983
  • Shi, Y., et al. (2021)
    Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607.
    Acta Neuropathol 141(5): 697-708
  • Goedert, M., et al. (2021)
    Tau Protein and Frontotemporal Dementias.
    Adv Exp Med Biol 1281: 177-199

2020

  • Scheres, S.H., Zhang, W., Falcon, B., Goedert, M. (2020)
    Cryo-EM structures of tau filaments.
    Curr Opin Struct Biol 64: 17-25
  • Zhang, W., et al. (2020)
    Novel tau filament fold in corticobasal degeneration.
    Nature 580(7802): 283-287

2019

  • Falcon, B., et al. (2019)
    Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules.
    Nature 568(7752): 420-423
  • Zhang, W., Falcon, B., Murzin, A.G., Fan, J., Crowther, R.A., Goedert, M., Scheres, S.H. (2019)
    Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases.
    Elife 8

2018

  • Falcon, B., et al. (2018)
    Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold.
    Acta Neuropathol 136(5): 699-708
  • Falcon, B., et al. (2018)
    Structures of filaments from Pick's disease reveal a novel tau protein fold.
    Nature 561(7721): 137-140
  • Kundel, F., et al. (2018)
    Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading.
    ACS Chem Neurosci 9(6): 1276-1282
  • Goedert, M., Falcon, B., Zhang, W., Ghetti, B., Scheres, S.H.W. (2018)
    Distinct Conformers of Assembled Tau in Alzheimer's and Pick's Diseases.
    Cold Spring Harb Symp Quant Biol 83: 163-171
  • Falcon, B., Noad, J., McMahon, H., Randow, F., Goedert, M. (2018)
    Galectin-8-mediated selective autophagy protects against seeded tau aggregation.
    J Biol Chem 293(7): 2438-2451

2017

  • Fitzpatrick, A.W.P., et al. (2017)
    Cryo-EM structures of tau filaments from Alzheimer's disease.
    Nature 547(7662): 185-190
  • Goedert, M., Masuda-Suzukake, M., Falcon, B. (2017)
    Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration.
    Brain 140(2): 266-278
  • McEwan, W.A., Falcon, B., Vaysburd, M., Clift, D., Oblak, A.L., Ghetti, B., Goedert, M., James, L.C. (2017)
    Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation.
    Proc Natl Acad Sci U S A 114(3): 574-579

2016

  • Jackson, S.J., et al. (2016)
    Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau.
    J Neurosci 36(3): 762-72

2015

  • Falcon, B., et al. (2015)
    Conformation determines the seeding potencies of native and recombinant Tau aggregates.
    J Biol Chem 290(2): 1049-65

© 2025 · Ryskeldi-Falcon Lab at the MRC Laboratory of Molecular Biology
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