Ingo Greger (; LMB website)
I studied gene expression mechanisms in Nick Proudfoot’s laboratory in Oxford for my Ph.D. After a short post-doc with Nick, I joined Ed Ziff’s laboratory in New York (at the NYU School of Medicine & HHMI), where I studied the cell biology of AMPA receptor trafficking. I joined the LMB’s Neurobiology Division at the beginning of 2004. I have a deep interest in molecular neurobiology, especially in the operation of ion channels and their role in synaptic plasticity mechanisms that underlie learning.
My long-term interests are structural and mechanistic insights into membrane proteins. I obtained my Ph.D in 2010 from the University of Cambridge, where I studied the structure and biochemistry of the respiratory complex I, in the lab of Dr. Leonid Sazanov. After the first post-doc in the same lab, I moved to New York (USA) to study the structure of a mitochondrial calcium channel (MCU) using cryo-EM, in the lab of Dr. Stephen Long at Memorial Sloan Kettering Cancer Center. After a short stint at SciLifeLab in Stockholm (Sweden), I returned to Cambridge where I’m currently developing new ligands towards AMPAR complexes in the Greger lab, in collaboration with AstraZeneca.
I did my Ph.D. in the Vyklicky lab in Prague, studying various physical and chemical modulators of NMDA glutamate receptors.
In the Greger lab I investigate gating properties and assembly rules of diverse AMPA receptor complexes, using electrophysiological recordings with rapid agonist application, required to resolve the uniquely fast gating kinetics characteristic of AMPARs.
I obtained my PhD in Electronics and Computer Sciences (de Planque group) at Southampton University, where I used α-haemolysing nanopore in planar lipid bilayers to detect cancer-related microRNA. I then moved to UCL (Sivilotti group), where I studied glycine receptor biophysics using electrophysiological techniques. In my current position (Ingo Greger group, LMB), I will study AMPAR biophysics using patch-clamp electrophysiology. I am interested in structure and function relationships of ligand gated ion channels.
I obtained my Ph.D from IST Austria (Sazanov group) in 2020 where I studied the structures and mechanisms of mitochondrial respiratory complexes. Afterwards I joined the Greger group as an EMBO Postdoctoral Fellow where I currently study the structures of various AMPAR complexes involved in the regulation of synaptic transmission using cryoEM.
I have a diploma in Physics from Vilnius University (Lithuania) and a PhD in Biophysics from the International School for Advanced Studies (SISSA, Trieste, Italy). Before joining MRC LMB I spent a few years in Department of Pharmacology, University College London.
My research focusses on structure-function relationships in ligand gated ion channels, and the principles of the action of both drugs and neurotransmitters at their cognate receptors.
I have extensive experience in high resolution single molecule recordings from ligand gated channels (low-noise patch-clamp recording) and fast concentration jumps to measure macroscopic currents in a system that mimics a synapse.
Mikel received his MSc and PhD degrees in Neuroscience from Pablo de Olavide University Seville, Spain (Antonio Rodríguez-Moreno group). His work focused on physiological and molecular bases of synaptic transmission and plasticity, using brain slice electrophysiology. He is interested on understanding the mechanisms that underlie synaptic plasticity, and their impact on brain physiology and disease.
I did my Ph.D. at the Institute of Biophysics, Chinese Academy of Sciences in Bejing, where I used single particle analysis (SPA) and tomography to study various protein complexes, including ion channels. Currently, I am using these cryo-EM techniques to investigate AMPAR receptor complexes playing prominent roles in CA1 hippocampus.
I am a PhD student in the Greger group, following a BSc in Biochemistry from the University of Edinburgh and an MPhil in Neuroscience from the University of Cambridge (Ole Paulsen group). I would like to understand how the state of synaptic plasticity is reflected in the molecular architecture of the synapse, by using a combination of electrophysiology and fluorescence microscopy.
- Saher Shaikh
- Alexandra Pinggera (Senior electrophysiologist at Metrion Biosciences)
- Jake Watson (Post-doc in Jonas lab at IST Austria)
- Bianka Kohegyi
- Peter Matthews (Electrophysiologist at Metrion Biosciences)
- Jan-Niklas Dohrke (PhD student at MPI Goettingen)
- Nejc Kejzar (Ph.D student at Cambridge University, PDN)
- Beatriz Herguedas-Frances (PI at Universidad de Zaragoza)
- Javier Garcia-Nafria (PI at Universidad de Zaragoza)
- Bishal Singh (Research Scientist at Paras Biopharmaceuticals)
- James Krieger (Marie Sklodowska-Curie Actions Individual Fellow in Carazo lab at Centro Nacional de Biotecnología, Madrid)
- Matti Pronker (Post-doc at Utrecht University)
- Hinze Ho (Ph.D student at Cambridge University, PDN)
- Luisa Christie (Senior electrophysiologist at Cerevance, Ltd)
- Jenna Montgomery (Senior electrophysiologist at Cerevance, Ltd)
- Lina Juknaite (Postdoc at Universidade NOVA de Lisboa)
- Maxim Rossman (Research Associate at University of Cambridge, Managing Director at Cambridge Oncometrix Limited)
- Skevi Krashia
- Ales Balik (Senior Scientist; Institute of Physiology, Prague)
- Madhav Sukumaran (Clinical Fellow in Neurosurgery; Brigham and Women’s Hospital)
- Andrew Penn (PI; University of Sussex)
- Devahi Niranjan
- Zsofia Nemoda (PI; Semmelweis University)
- Pearl Akamine (Scientist at Clinical Bioreagent Center)