2024
- Greger, I.H. (30th November 2024)
Regulating calcium flux through AMPA glutamate receptors.
Cell Calcium 123: 102934 - Ivica, J., et al. (13th October 2024)
Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization.
Nat Struct Mol Biol 31(10): 1601-1613 - Stockwell, I., Watson, J.F., Greger, I.H. (1st July 2024)
Tuning synaptic strength by regulation of AMPA glutamate receptor localization.
Bioessays 46(7): e2400006
2023
- Zhang, D., et al. (13th September 2023)
Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor.
Nature 621(7980): 877-882 - Zhang, D., Lape, R., Shaikh, S.A., Kohegyi, B.K., Watson, J.F., Cais, O., Nakagawa, T., Greger, I.H. (25th March 2023)
Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics.
Nat Commun 14(1): 1659
2022
- Herguedas, B., et al. (8th February 2022)
Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor.
Nat Commun 13(1): 734
2021
- Matthews, P.M., Pinggera, A., Kampjut, D., Greger, I.H. (1st October 2021)
Biology of AMPA receptor interacting proteins - From biogenesis to synaptic plasticity.
Neuropharmacology 197: 108709 - Hansen, K.B., et al. (2021)
Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Pharmacol Rev 73(4): 298-487 - Rajab, S., Bismin, L., Schwarze, S., Pinggera, A., Greger, I.H., Neuweiler, H. (9th September 2021)
Allosteric coupling of sub-millisecond clamshell motions in ionotropic glutamate receptor ligand-binding domains.
Commun Biol 4(1): 1056 - Watson, J.F., Pinggera, A., Ho, H., Greger, I.H. (23rd August 2021)
AMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP γ8 interactions.
Nat Commun 12(1): 5083 - Zhang, D., Watson, J.F., Matthews, P.M., Cais, O., Greger, I.H. (2nd June 2021)
Gating and modulation of a hetero-octameric AMPA glutamate receptor.
Nature 594(7863): 454-458
2020
- Dohrke, J.N., Watson, J.F., Birchall, K., Greger, I.H. (23rd October 2020)
Characterizing the binding and function of TARP γ8-selective AMPA receptor modulators.
J Biol Chem 295(43): 14565-14577 - Ho, H., Fowle, A., Coetzee, M., Greger, I.H., Watson, J.F. (1st August 2020)
An inhalation anaesthesia approach for neonatal mice allowing streamlined stereotactic injection in the brain.
J Neurosci Methods 342: 108824
2019
- Greger, I.H., Mayer, M.L. (8th August 2019)
Structural biology of glutamate receptor ion channels: towards an understanding of mechanism.
Curr Opin Struct Biol 57: 185-195 - Krieger, J., Lee, J.Y., Greger, I.H., Bahar, I. (1st May 2019)
Activation and desensitization of ionotropic glutamate receptors by selectively triggering pre-existing motions.
Neurosci Lett 700: 22-29 - Herguedas, B., Watson, J.F., Ho, H., Cais, O., García-Nafría, J., Greger, I.H. (26th April 2019)
Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP γ8.
Science 364(6438) - Lee, J.Y., et al. (5th February 2019)
Druggability Simulations and X-Ray Crystallography Reveal a Ligand-Binding Site in the GluA3 AMPA Receptor N-Terminal Domain.
Structure 27(2): 241-252.e3 - Buonarati, O.R., Hammes, E.A., Watson, J.F., Greger, I.H., Hell, J.W. (1st January 2019)
Mechanisms of postsynaptic localization of AMPA-type glutamate receptors and their regulation during long-term potentiation.
Sci Signal 12(562)
2017
- Davies, B., et al. (15th October 2017)
A point mutation in the ion conduction pore of AMPA receptor GRIA3 causes dramatically perturbed sleep patterns as well as intellectual disability.
Hum Mol Genet 26(20): 3869-3882 - Greger, I.H., Watson, J.F., Cull-Candy, S.G. (17th May 2017)
Structural and Functional Architecture of AMPA-Type Glutamate Receptors and Their Auxiliary Proteins.
Neuron 94(4): 713-730 - Watson, J.F., Ho, H., Greger, I.H. (14th March 2017)
Synaptic transmission and plasticity require AMPA receptor anchoring via its N-terminal domain.
Elife 6
2016
- García-Nafría, J., Herguedas, B., Watson, J.F., Greger, I.H. (1st October 2016)
The dynamic AMPA receptor extracellular region: a platform for synaptic protein interactions.
J Physiol 594(19): 5449-58 - Elegheert, J., et al. (15th July 2016)
Structural basis for integration of GluD receptors within synaptic organizer complexes.
Science 353(6296): 295-9 - García-Nafría, J., Watson, J.F., Greger, I.H. (6th June 2016)
IVA cloning: A single-tube universal cloning system exploiting bacterial In Vivo Assembly.
Sci Rep 6: 27459 - Herguedas, B., et al. (29th April 2016)
Structure and organization of heteromeric AMPA-type glutamate receptors.
Science 352(6285): aad3873
2015
- Krieger, J., Bahar, I., Greger, I.H. (15th September 2015)
Structure, Dynamics, and Allosteric Potential of Ionotropic Glutamate Receptor N-Terminal Domains.
Biophys J 109(6): 1136-48 - Dutta, A., Krieger, J., Lee, J.Y., Garcia-Nafria, J., Greger, I.H., Bahar, I. (1st September 2015)
Cooperative Dynamics of Intact AMPA and NMDA Glutamate Receptors: Similarities and Subfamily-Specific Differences.
Structure 23(9): 1692-1704 - Taylor, J.C., et al. (18th July 2015)
Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.
Nat Genet 47(7): 717-726
2014
- Cais, O., Herguedas, B., Krol, K., Cull-Candy, S.G., Farrant, M., Greger, I.H. (23rd October 2014)
Mapping the interaction sites between AMPA receptors and TARPs reveals a role for the receptor N-terminal domain in channel gating.
Cell Rep 9(2): 728-40
2013
- Penn, A.C., Balik, A., Greger, I.H. (18th April 2013)
Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system.
Front Neurosci 7: 61 - Balik, A., Penn, A.C., Nemoda, Z., Greger, I.H. (20th January 2013)
Activity-regulated RNA editing in select neuronal subfields in hippocampus.
Nucleic Acids Res 41(2): 1124-34 - Penn, A.C., Balik, A., Greger, I.H. (20th January 2013)
Steric antisense inhibition of AMPA receptor Q/R editing reveals tight coupling to intronic editing sites and splicing.
Nucleic Acids Res 41(2): 1113-23 - Herguedas, B., Krieger, J., Greger, I.H. (2013)
Receptor heteromeric assembly-how it works and why it matters: the case of ionotropic glutamate receptors.
Prog Mol Biol Transl Sci 117: 361-86
2012
- Penn, A.C., Balik, A., Wozny, C., Cais, O., Greger, I.H. (8th November 2012)
Activity-mediated AMPA receptor remodeling, driven by alternative splicing in the ligand-binding domain.
Neuron 76(3): 503-10 - Dutta, A., Shrivastava, I.H., Sukumaran, M., Greger, I.H., Bahar, I. (7th November 2012)
Comparative dynamics of NMDA- and AMPA-glutamate receptor N-terminal domains.
Structure 20(11): 1838-49 - Shanks, N.F., et al. (28th June 2012)
Differences in AMPA and kainate receptor interactomes facilitate identification of AMPA receptor auxiliary subunit GSG1L.
Cell Rep 1(6): 590-8 - Sukumaran, M., Penn, A.C., Greger, I.H. (2012)
AMPA receptor assembly: atomic determinants and built-in modulators.
Adv Exp Med Biol 970: 241-64
2011
- Jensen, M.H., Sukumaran, M., Johnson, C.M., Greger, I.H., Neuweiler, H. (18th November 2011)
Intrinsic motions in the N-terminal domain of an ionotropic glutamate receptor detected by fluorescence correlation spectroscopy.
J Mol Biol 414(1): 96-105 - Sukumaran, M., Rossmann, M., Shrivastava, I., Dutta, A., Bahar, I., Greger, I.H. (2nd March 2011)
Dynamics and allosteric potential of the AMPA receptor N-terminal domain.
EMBO J 30(5): 972-82 - Rossmann, M., Sukumaran, M., Penn, A.C., Veprintsev, D.B., Babu, M.M., Greger, I.H. (2nd March 2011)
Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers.
EMBO J 30(5): 959-71
2009
- Penn, A.C., Greger, I.H. (18th November 2009)
Sculpting AMPA receptor formation and function by alternative RNA processing.
RNA Biol 6(5): 517-21
2008
- Penn, A.C., Williams, S.R., Greger, I.H. (19th November 2008)
Gating motions underlie AMPA receptor secretion from the endoplasmic reticulum.
EMBO J 27(22): 3056-68
2007
- Greger, I.H., Ziff, E.B., Penn, A.C. (16th August 2007)
Molecular determinants of AMPA receptor subunit assembly.
Trends Neurosci 30(8): 407-16 - Greger, I.H., Esteban, J.A. (1st June 2007)
AMPA receptor biogenesis and trafficking.
Curr Opin Neurobiol 17(3): 289-97
2006
- Greger, I.H., Akamine, P., Khatri, L., Ziff, E.B. (6th July 2006)
Developmentally regulated, combinatorial RNA processing modulates AMPA receptor biogenesis.
Neuron 51(1): 85-97
2003
- Greger, I.H., Khatri, L., Kong, X., Ziff, E.B. (13th November 2003)
AMPA receptor tetramerization is mediated by Q/R editing.
Neuron 40(4): 763-74
2002
- Greger, I.H., Khatri, L., Ziff, E.B. (30th May 2002)
RNA editing at arg607 controls AMPA receptor exit from the endoplasmic reticulum.
Neuron 34(5): 759-72
2000
- Greger, I.H., Aranda, A., Proudfoot, N. (18th July 2000)
Balancing transcriptional interference and initiation on the GAL7 promoter of Saccharomyces cerevisiae.
Proc Natl Acad Sci U S A 97(15): 8415-20 - Boyd, D.C., Greger, I.H., Murphy, S. (18th April 2000)
In vivo footprinting studies suggest a role for chromatin in transcription of the human 7SK gene.
Gene 247(1-2): 33-44
1998
- Greger, I.H., Proudfoot, N.J. (17th August 1998)
Poly(A) signals control both transcriptional termination and initiation between the tandem GAL10 and GAL7 genes of Saccharomyces cerevisiae.
EMBO J 17(16): 4771-9 - Greger, I.H., Demarchi, F., Giacca, M., Proudfoot, N.J. (1st March 1998)
Transcriptional interference perturbs the binding of Sp1 to the HIV-1 promoter.
Nucleic Acids Res 26(5): 1294-301