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In work led by Lucas, we reveal that perinuclear positioning of multiple organelles contributes to adaptive gene expression in response to oxidative stress. You can read more here.

Congratulations Dr Chilaeva! Sabila’s work with Mark and the Carter lab sheds light on the molecular basis of recognition of diverse localising mRNAs by the transport machinery!

Kashish, Sabila and Mark combine cryo-EM, single-molecule reconstitution assays and functional studies in vivo to reveal how specificity is achieved during dynein-based mRNA transport. You can read more here.

David’s preprint is now published as a research article in JCB. The work, which was a collaboration with several groups, provides insights into the organismal and cellular effects of disease-associated mutations in dynein and reveals a non-canonical, load-related role of the motor in mitotic progression.

Congratulations to Wong and our collaborators at AstraZeneca! You can read the manuscript here.

Our collaborative work with the Ephrussi lab at EMBL on regulation of kinesin-1 by Tm1 is published. This includes reconstitution of dynein and kinesin motors bound to a native cargo! You can read more here.

The work of Vanesa, Lucas, Lily and many terrific collaborators identifying HEATR5B as a novel player in dynein-based trafficking of endosomal membranes has been accepted for publication. You can read the paper here.

Congratulations to Yaiza for passing her viva with flying colours!

David Salvador Garcia’s PhD work has been posted (see Publications page for details). David combined genetics and biochemistry to shed light on the effects of dynein disease-associated mutations, as well as of a novel, force-sensitive mutation in the microtubule binding domain. The latter mutation provides evidence of a novel role of dynein in anaphase progression. […]

Patrick O’Donnell and Eve Mehtab have joined the group. They are undergraduate students at TU Delft and the University of Bristol, respectively.