The “cell” is the simplest living homeostatic unity with complex characteristics: identity, evolution, time, memory, communication, resilience. In general terms the cell can be thought as a simplified molecular ecosystem, where complex living behaviours arise from the interplay between organic and mechano-chemical elements, many of which comes from the environmental context.
The macromolecular basis of organelle shape and remodelling
Our lab searches for the ruling biophysical and chemical principles which allow cellular life with a focus on the architecture of the nucleus, the main membrane compartment which transduce information. We aim to answer to this question: how does compartment shape and function emerge from macromolecules organisation according to physiological/environmental changes?
We carry out both blue-sky and biomedicine research projects on the macromolecular basis of nuclear shape, architecture and remodelling and we develop new tools/methods to reach such goals. We use mainly an in-cell structural biology approach.
We work as an interdisciplinary and collaborative team of scientists whose goal is to produce high-quality research results.
