Our interest is in developing new tools to understand nuclear-cytoskeletal organisation in four dimensions and enable experiments and data analysis which are impossible with existing technologies. With the support of the mechanical and electronic workshop and of collaborators, we also aim to couple cell biology and structural techniques and integrate data at different scales and resolutions to study nuclear remodelling processes. Here the main methods used in the lab:
- Electron cryo Tomography / Electron cryo microscopy
- Correlative Light and Electron Microscopy
- Light microscopy and cryo light microscopy
- Integrative structural biology
- Biochemistry methods
- Cell biology methods
- Custom grid design
- Molecular modelling
- Software development using AI
- Biophysical methods
