Our interest is in developing new tools to understand nuclear structural organisation in four dimensions. With the support of the mechanical and electronic workshop and of collaborators, we aim to couple cell biology and structural methods to investigate biological phenomena in vivo. The final goal is to integrate data at different scales and resolutions to study nuclear remodelling processes. Here the main methods used in the lab:
- Electron cryo Tomography / Electron cryo microscopy
- Correlative Light and Electron Microscopy
- Light microscopy and cryo light microscopy
- Integrative structural biology
- Biochemistry methods
- Cell biology methods
- Custom grid design
- Molecular modelling
- Software development using AI
- Biophysical methods
