Preprints
Kolata, P.*, dos Santos, Á.*, Knowles, O., Dendooven, T.*#, Allegretti, M.# Molecular architecture and spatial organisation of proteasomes in the human sperm nucleus. BioRxiv (2025). https://doi.org/10.64898/2025.12.16.694293
Dendooven, T.#, Ebrahimi, M., dos Santos, Á., Dhondt, W., Knowles, O., Hale, T., Burt, A., Mehdipour, A. R.# & Allegretti, M.# In-cell structure of a LINC complex reveals the molecular basis for membrane remodelling and head-to-tail coupling in sperm cells. BioRxiv (2025). https://doi.org:10.1101/2025.08.04.668116
dos Santos, Á., Knowles, O., Hale, T., Hale, V. L., Burt, A., Kolata, P., Cannone, G., Bellini, D., Barford, D. & Allegretti, M.#. Human spermatogenesis leads to a reduced nuclear pore structure and function. BioRxiv (2025). https://doi.org/10.1101/2024.10.30.620797
2026
- Hale, T., Hale, V.L., Kolata, P., Dos Santos, Á., Allegretti, M. (2026 )
Paclitaxel compromises nuclear integrity in interphase through SUN2-mediated cytoskeletal coupling.
J Cell Sci 139(12)
2024
- Last, M.G.F., Abendstein, L., Voortman, L.M., Sharp, T.H. (2024 )
Streamlining segmentation of cryo-electron tomography datasets with Ais.
Elife 13
2023
- Dos Santos, Á., Rollins, D.E., Hari-Gupta, Y., McArthur, H., Du, M., Ru, S.Y.Z., Pidlisna, K., Stranger, A., Lorgat, F., Lambert, D., Brown, I., Howland, K., Aaron, J., Wang, L., Ellis, P.J.I., Chew, T.L., Martin-Fernandez, M., Pyne, A.L.B., Toseland, C.P. (2023 )
Autophagy receptor NDP52 alters DNA conformation to modulate RNA polymerase II transcription.
Nat Commun 14(1): 2855
2021
- Zimmerli, C.E., Allegretti, M., Rantos, V., Goetz, S.K., Obarska-Kosinska, A., Zagoriy, I., Halavatyi, A., Hummer, G., Mahamid, J., Kosinski, J., Beck, M. (2021 )
Nuclear pores dilate and constrict in cellulo.
Science 374(6573): eabd9776 - Zila, V., Margiotta, E., Turoňová, B., Müller, T.G., Zimmerli, C.E., Mattei, S., Allegretti, M., Börner, K., Rada, J., Müller, B., Lusic, M., Kräusslich, H.G., Beck, M. (2021 )
Cone-shaped HIV-1 capsids are transported through intact nuclear pores.
Cell 184(4): 1032-1046.e18 - Dos Santos, Á., Fili, N., Pearson, D.S., Hari-Gupta, Y., Toseland, C.P. (2021 )
High-throughput mechanobiology: Force modulation of ensemble biochemical and cell-based assays.
Biophys J 120(4): 631-641
2020
- Allegretti, M., Zimmerli, C.E., Rantos, V., Wilfling, F., Ronchi, P., Fung, H.K.H., Lee, C.W., Hagen, W., Turoňová, B., Karius, K., Börmel, M., Zhang, X., Müller, C.W., Schwab, Y., Mahamid, J., Pfander, B., Kosinski, J., Beck, M. (2020 )
In-cell architecture of the nuclear pore and snapshots of its turnover.
Nature 586(7831): 796-800 - Lee, B.G., Merkel, F., Allegretti, M., Hassler, M., Cawood, C., Lecomte, L., O'Reilly, F.J., Sinn, L.R., Gutierrez-Escribano, P., Kschonsak, M., Bravo, S., Nakane, T., Rappsilber, J., Aragon, L., Beck, M., Löwe, J., Haering, C.H. (2020 )
Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism.
Nat Struct Mol Biol 27(8): 743-751 - Lee, C.W., Wilfling, F., Ronchi, P., Allegretti, M., Mosalaganti, S., Jentsch, S., Beck, M., Pfander, B. (2020 )
Selective autophagy degrades nuclear pore complexes.
Nat Cell Biol 22(2): 159-166
2019
- Thaller, D.J., Allegretti, M., Borah, S., Ronchi, P., Beck, M., Lusk, C.P. (2019 )
An ESCRT-LEM protein surveillance system is poised to directly monitor the nuclear envelope and nuclear transport system.
Elife 8
2018
- Cossio, P., Allegretti, M., Mayer, F., Müller, V., Vonck, J., Hummer, G. (2018 )
Bayesian inference of rotor ring stoichiometry from electron microscopy images of archaeal ATP synthase.
Microscopy (Oxf) 67(5): 266-273
2015
- Allegretti, M., Klusch, N., Mills, D.J., Vonck, J., Kühlbrandt, W., Davies, K.M. (2015 )
Horizontal membrane-intrinsic α-helices in the stator a-subunit of an F-type ATP synthase.
Nature 521(7551): 237-40
2014
- Allegretti, M., Mills, D.J., McMullan, G., Kühlbrandt, W., Vonck, J. (2014 )
Atomic model of the F420-reducing [NiFe] hydrogenase by electron cryo-microscopy using a direct electron detector.
Elife 3: e01963 - Zhang, C., Allegretti, M., Vonck, J., Langer, J.D., Marcia, M., Peng, G., Michel, H. (2014 )
Production of fully assembled and active Aquifex aeolicus F1FO ATP synthase in Escherichia coli.
Biochim Biophys Acta 1840(1): 34-40
2010
- Luisi, P.L., Allegretti, M., Pereira de Souza, T., Steiniger, F., Fahr, A., Stano, P. (2010 )
Spontaneous protein crowding in liposomes: a new vista for the origin of cellular metabolism.
Chembiochem 11(14): 1989-92
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