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Cryo-electron micrograph of tau filaments from a patient with Alzheimer’s disease. From dataset <a href "https://www.ebi.ac.uk/pdbe/emdb/empiar/entry/10230/">EMPIAR-10230</a>. — Cryo-electron micrograph of tau filaments from a patient with Alzheimer’s disease. From dataset EMPIAR-10230.

Electron cryo-tomography (cryo-ET) of tau filaments (magenta) within an extracellular vesicle from the brain of an individual with Alzheimer's disease. Adapted from Fowler, Behr et al. 2023. BioRxiv doi.org/10.1101/2023.04.30.537820. — Electron cryo-tomography (cryo-ET) of tau filaments (magenta) within an extracellular vesicle from the brain of an individual with Alzheimer’s disease. Adapted from Fowler, Behr et al. 2023. BioRxiv doi.org/10.1101/2023.04.30.537820.

Cryo-EM map (<a href="https://www.ebi.ac.uk/pdbe/entry/emdb/EMD-0527" >EMD-0527</a>) and model (<a href="https://www.ebi.ac.uk/pdbe/entry/pdb/6nwp">PDB-6nwp</a>) of tau filaments from chronic traumatic encephalopathy at 2.3 Å-resolution. — Cryo-EM map (EMD-0527) and model (PDB-6nwp) of tau filaments from chronic traumatic encephalopathy at 2.3 Å-resolution.

Tau filaments (green) within vesicles (red) propagating between primary neurons. Adapted from Falcon et al. 2018. JBC 293, 2438–2451.

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