Gallery Cryo-electron micrograph of tau filaments from a patient with Alzheimer’s disease. From dataset EMPIAR-10230.Electron cryo-tomography (cryo-ET) of tau filaments (magenta) within an extracellular vesicle from the brain of an individual with Alzheimer’s disease. Adapted from Fowler, Behr et al. 2023. BioRxiv doi.org/10.1101/2023.04.30.537820.Cryo-EM map (EMD-0527) and model (PDB-6nwp) of tau filaments from chronic traumatic encephalopathy at 2.3 Å-resolution.Tau filaments (green) within vesicles (red) propagating between primary neurons. Adapted from Falcon et al. 2018. JBC 293, 2438–2451.