Gallery Cryo-EM map (EMD-0527) and model (PDB-6nwp) of tau filaments from chronic traumatic encephalopathy at 2.3 Å-resolution.Cryo-electron micrograph of tau filaments from a patient with Alzheimer’s disease. From dataset EMPIAR-10230.Cross-sectional views of cryo-EM reconstructions of tau filaments from three cases of chronic traumatic encephalopathy. Adapted from Falcon et al. 2019. Nature 568, 420–423.Sequence alignment and schematic representations of the tau filament folds from corticobasal degeneration (CBD), Pick’s disease (PiD), Alzheimer’s disease (AD) and chronic traumatic encephalopathy (CTE). Adapted from Zhang et al. 2020. Nature 580, 283–287.Tau filaments (green) within vesicles (red) propagating between primary neurons. Adapted from Falcon et al. 2018. JBC 293, 2438–2451.