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Home > LMB In The News > Double spiral structure is unique to TDP-43 filament behind ALS and FTD neurodegenerative diseases

Double spiral structure is unique to TDP-43 filament behind ALS and FTD neurodegenerative diseases

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A recent paper from Benjamin Ryskeldi-Falcon’s group reveals the first atomic structure of TDP-43 filaments from the brains of people with ALS and FTD diseases. The discovered structure possesses a unique double-spiral fold at its core, differentiating it from all other amyloidogenic proteins observed so far. More…