A chain of events

Linear ubiquitin chains whose very existence once was debated, now are known to play a critical role in an inflammatory disease, thanks to the discovery of an enzyme. David Komander’s group from the LMB are amongst a group of scientists researching the enzymes of the ubiquitin system, which has already shown how mutations in the gene for OTULIN, an enzyme belonging to the OTU family of deubiquitinases, cause a rare systemic inflammatory disease. More…