Author: Gallagher, James
Title: Sharp focus on Alzheimer’s may help target drugs
Reference BBC News 5 July 2017
Year: 2017
Type: Science
Subject: Abnormal deposits that build up in the brain during Alzheimer’s have been pictured in unprecedented detail in research led by Sjors Scheres and Michel Goedert
Keywords: Alzheimer’s; Sjors Scheres; Michel Goedert; beta amyloid; Parkinson’s; alpha synuclein; tau; neurodegenerative disease;”resolution revolution”; tangles; Nature journal
Photographs: Artists image of a tangle of tau (LMB)Author: Brackley, Paul
Title: How Cambridge scientists are exploring the incredible transport system inside our cells
Reference Cambridge Independent 12 July 2017
Year: 2017
Type: Science
Subject: Simon Bullock discusses his research into intracellular trafficking of RNA, and talks about the importance of science outreach in inspiring the next generation of young scientists.
Keywords: Simon Bullock; tiny machines; motor proteins; cargo; cells; RNA; cytoskeleton; microtubules; viruses; neurodegeneration; fruit flies; cryo-electron microscope; dynein; Andrew Carter; AstraZeneca; Mathias Pasche; Microscopes4Schools; vesicles; Cambridge Biomedical Campus
Photographs: Simon Bullock in lab; picture of the lab taken from the front of the buildingAuthor: Alzforum
Title: Tau Filaments from the Alzheimer’s Brain Revealed at Atomic Resolution
Reference Alzforum 7 July 2017
Year: 2017
Type: Science
Subject: Tau filaments isolated from an Alzheimer’s brain are the latest, high-profile exploit of cryo-electron microscopy. Using his technique his, Sjors Scheres, teamed up with Michel Goedert,to solve 3.4-Angstrom resolution structures of both straight and paired helical filaments of tau
Keywords: Alzheimer’s; Sjors Scheres; Michel Goedert; tau; Cryo-EM microscopy; fibrils; β-helix; C-shaped protofilament monomer; AD; paired helical filaments (PHFs); straight filaments (SFs); N-terminus; “fuzzy coat”; Nature
Photographs:Author: Everts, Sarah
Title: A new view of the spliceosome
Reference Chemical & Engineering News 26 May 2017
Year: 2017
Type: Science
Subject: Kiyoshi Nagai’s group capture important state of cellular machine responsible for making humans more complex than worms
Keywords: Cellular machine; worm; Caenorhabditis elegans; spliceosome; RNA; genome; cryo-electron microscopy; atomic; ribonucleoproteins; Kiyoshi Nagai; Pei-Chun Lin; Clemens Plaschka; Nature journal; splicing
Photographs:Author: ScienceDaily
Title: Building better brains: A bioengineered upgrate for organoids
Reference Science Daily 31 May 2017
Year: 2017
Type: Science
Subject: Study by Madeline Lancaster and collaborators at IMBA is one of the first attempts to combine organoids with bioengineering
Keywords: organoids; bioengineering; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA); cerebral; Madeline Lancaster; engineered cerebral organoids (enCORs); neurons; PLGA; stem cell
Photographs:Author: University of Cambridge - Research
Title: Leprosy turns the immune system against itself, study finds
Reference University of Cambridge - Research 30 August 2017
Year: 2017
Type: Science
Subject: An international team of scientists, including Lalita Ramakrishnan’s group in the University of Cambridge Molecular Immunity Unit, based at the LMB, have discovered that Leprosy hijacks our immune system, turning an important repair mechanism into one that causes potentially irreparable damage to our nerve cells.
Keywords: Lalita Ramakrishnan; Leprosy; immune system; zebrafish; Mycobacterium leprae; lepromatosis; multiple sclerosis; Guillain–Barré syndrome; Schwann cells; myelin; Department of Medicine; ‘bubbles’; macrophages; ‘big eaters’; ‘Pac-Man’; PGL-1; bacteria; nerve cells; hijacking
Photographs: Hand showing leprosy (drawn)Author: Devlin, Hannah; Davis, Nicola
Title: Nobel prize in chemistry awarded for method to visualise biomolecules
Reference The Guardian 4 October 2017
Year: 2017
Type: Awards & Prizes
Subject: The 2017 Nobel prize in chemistry is awarded to Richard Henderson along with Jacques Dubochet and Joachim Frank for developing the method for generating 3D images of life-building structures
Keywords: Richard Henderson; Jacques Dubochet; Joachim Frank; X-ray crystallography; cryo-electron microscopy (cryo-EM); 3D structure; Venki Ramakrishnan; Royal Society; “visionary”; frozen; Nobel prize
Photographs: Artist image of the three winners; image showing the resolution before cry-EM and after.Author: Cressey, Daniel; Callaway, E.
Title: Cryo-electron microscopy wins chemistry Nobel
Reference Nature 5 October 2017
Year: 2017
Type: Awards & Prizes
Subject: Jacques Dubochet, Joachim Frank and Richard Henderson were awarded the 2017 chemistry Nobel prize for their work in developing cryo-electron microscopy (cryo-EM).
Keywords: Richard Henderson; Jacques Dubochet; Joachim Frank; Nobel prize; chemistry; cryo-microscopy (cryo-EM); X-ray crystallography; Nigel Unwin; 3D structures; Venki Ramakrishnan; Sjors Scheres
Photographs: Portrait images of the three winnersAuthor: Moody, Oliver
Title: Image pioneer wins Nobel chemistry prize
Reference The Times 5 October 2017
Year: 2017
Type: Awards & Prizes
Subject: Richard Henderson along with Jacques Dubochet, Joachim Frank is awarded the 2017 chemistry Nobel prize for their work in developing cryo-electron microscopy (cryo-EM).
Keywords: Richard Henderson; Jacques Dubochet; Joachim Frank; Nobel prize; Chemistry; cryo-electron microscopy (cryo-EM); Venki Ramakrishnan; imaging revolution
Photographs:Author: Medical Research Council News
Title: MRC scientist wins 2017 Nobel Prize in Chemistry
Reference MRC News 4 October 2017
Year: 2017
Type: Awards & Prizes
Subject: Richard Henderson has been awarded the 2017 Nobel Prize in Chemistry, alongside Jacques Dubochet and Joachim Frank
Keywords: Richard Henderson; Nobel prize; chemistry; Jacques Dubochet; Joachim Frank; cryo-electron microscopy (cryo-EM); X-ray crystallography; Nigel Unwin; Hugh Pelham; atomic structure; 3D image
Photographs: Richard Henderson in lab; Richard with model; portrait shot (all MRC LMB images)Author: Brackley, Paul
Title: Another medal for Cambridge’s own Nobel Prize factory
Reference Cambridge Independent 11 October
Year: 2017
Type: Awards & Prizes
Subject: Richard Henderson has been awarded the 2017 Nobel Prize in Chemistry, alongside Jacques Dubochet and Joachim Frank
Keywords: Richard Henderson; Nobel prize; Jacques Dubochet; Joachim Frank; cryo-electron microscopy (cryo-EM); X-ray crystallography; Sjors Scheres; Nigel Unwin; 3D; Hugh Pelham; Fred Sanger
Photographs: Richard in front of Nobel laureates of the LMB banner.Author: Cambridge Independent
Title: £2.1m to help develop drugs that stop cancer cells growing
Reference Cambridge Independent 23 August 2017
Year: 2017
Type: Funding
Subject: David Barford will lead a five-year project that aims to identify and develop potential new drugs to stop cancer cells growing.
Keywords: David Barford; APC/C complex; grant; Cancer Research UK; drug compounds; cancer cells; funding; Science Committee Programme Awards
Photographs: David Barford head shotAuthor: Cambridge News
Title: Breakthrough could lead to new Alzheimer’s treatment
Reference Cambridge News 7 July 2017
Year: 2017
Type: Science
Subject: Michel Goedert and Sjors Scheres lead research on Alzheimer’s using cryo-EM to give the first close up image of tangled proteins in the brain.
Keywords: Michel Goedert; Sjors Scheres; Alzheimer’s; tau tangles; neurodegenerative disease; cryo-electron microscopy; protein; filaments; transport system
Photographs:Author: von Radowitz, John
Title: Image of tangled brain protein may help to treat Alzheimer’s
Reference (i) 6 July 2017
Year: 2017
Type: Science
Subject: Michel Goedert leads research on Alzheimer’s using cryo-EM to give the first close up image of tangled proteins in the brain.
Keywords: Michel Goedert; tau tangles; Alzheimer’s; cryo-electron microscopy; filaments; protein; transport system
Photographs:Author: Brackley, Paul
Title: Youth champion among those in Queen’s Birthday Honours
Reference Cambridge Independent 21 June 2017
Year: 2017
Type: Awards & Prizes
Subject: John Sulston made Companion of Honour for “services to science and society” in the Queen’s Birthday Honours
Keywords: John Sulston; Queen’s Birthday Honours; human genome; sequencing; Sydney Brenner; Robert Horvitz; Sanger Institute; Companion of Honour
Photographs:Author: Brackley, Paul; Comber, Ben
Title: City’s Brexit brain drain warning to government
Reference Cambridge Independent 5 July 2017
Year: 2017
Type: Miscellaneous
Subject: Daniel Zeichner visits the LMB and hears about the importance of EU Nationals
Keywords: Daniel Zeichner; ‘Nobel Prize factory’; Hugh Pelham; Brexit; EU; funding; brain drain
Photographs: Hugh with Daniel Zeichner in a labAuthor: Cambridge News
Title: Working together on ‘Nobel factory’
Reference Cambridge News 5 March 2013
Year: 2013
Type: Architecture and Buildings
Subject: New LMB building and the teamwork of Cambridge-based firms that helped to get the building built.
Keywords: Cambridge Biomedical Campus; ‘Nobel Prize factory’; Addenbrooke’s 2020 vision; £212 million; Januarys, Dodson Jones; Hewitsons; new building
Photographs: Outside shot of new buildingAuthor: Brackley, Paul
Title: Family-friendly open day at world-famous Laboratory for Molecular Biology in Cambridge will offer amazing insight
Reference Cambridge Independent 16 June 2017
Year: 2017
Type: Events and Celebrations
Subject: 2017 sees the LMB open its doors to the public and offer activities and talks about the work that takes place at the lab.
Keywords: Open day; ‘Nobel Prize factory’; Cambridge Biomedical Campus;
Photographs: Simon Bullock in lab; Charlie Morgan; Image of the atrium from 2013 open dayAuthor: Fyfe, Ian
Title: Tau pathology in atomic detail
Reference Nature Reviews Neurology 21 July 2017
Year: 2017
Type: Science
Subject: Michel Goedert and Sjors Scheres lead research on Alzheimer’s using cryo-EM to give the first close up image of tangled proteins in the brain.
Keywords: tau filaments; Alzheimer’s Disease; Michel Goedert; Sjors Scheres; cryo-EM; myloid-β; α-synuclein; prions; X-ray crystallography; 3D crystals
Photographs:Author: MRC News
Title: Toxic formaldehyde is produced inside our own cells, scientists discover
Reference MRC News 17 August 2017
Year: 2017
Type: Science
Subject: New research involving KJ Patel revealed that most of the toxin formaldehyde in our bodies does not come from our environment – it is a by- product of essential reactions inside our own cells.
Keywords: Ketan Patel; toxic formaldehyde; folate; BRCA1; BRCA2; cancer; one-carbon cycle; formate
Photographs:Author: Kramer, Katrina
Title: The birth of the cool. Super cool microscopy wins the 2017 Nobel prize in chemistry
Reference Chemistry World 13 October 2017
Year: 2017
Type: Awards & Prizes
Subject: Richard Henderson talks about the development of cryo-EM that led to him sharing the 2017 Nobel prize for chemistry
Keywords: Richard Henderson; Nigel Unwin; Sjors Scheres; X-ray crystallography; Cryo-EM; 3D crystal; bacteriorhodopsin; Lori Passmore; ‘blobology era’
Photographs: Richard with model of bacteriorhodopsin.Author: Cancer Research UK
Title: Researchers “drug the undruggable” through unique collaboration
Reference Cancer Research UK 18 October 2017
Year: 2017
Type: Science
Subject: A new approach to targeting key cancer-linked proteins, thought to be ‘undruggable’, has been discovered through an alliance between industry and academia created by Cancer Research UK. David Komander’s group is one of the groups involved in this unique collaboration.
Keywords: David Komander; p53; ubiquitin-proteasome system; USP7; ‘undruggable’; cancer;
Photographs:Author: Nicodemo, Allie
Title: Northeastern researchers discover fundamental rules for how the brain controls movement
Reference News @ Northeastern 23 October 2017
Year: 2017
Type: Science
Subject: Research published in Nature, describes for the first time the ability to predict, test, and confirm with unprecedented detail how a nematode’s brain controls the way it moves. Colleagues from Bill Schafer’s group tested the predictions by killing individual neurons from the nematode brain with a laser.
Keywords: Emma Towlson; Northeastern; “microsurgeries”; William Schafer; nematode brain; neurons; body movement; muscle; laser;
Photographs: Emma Towlson, Postdoc at the Center for Complex Network Science ResearchAuthor: Chicurel, Marina
Title: PINK1 Caught on the Brink of Phosporylation
Reference ALZFORUM 3 November 2017
Year: 2017
Type: Science
Subject: Researchers have caught a rare view of an unusual kinase poised to phosphorylate its substrate. Led by David Komander,, the researchers reported the crystal structure of the kinase PINK1 bound to ubiquitin
Keywords: David Komander; PINK1; phosphorylate; pre-catalytic state; Alexander Schubert; Pediculus humanus corporis (body louse); E-coli; T66V; L67N; Ub TVLN; WT ubiquitin; N-lobe; Parkinsonism; mutations; kinase; ATP; Parkin; Ser65; “insertions”
Photographs:Author: Kassam, Zara
Title: Cryo-electron microscopy used to identify CPF protein structure
Reference Drug Target Review 30 October 2017
Year: 2017
Type: Science
Subject: Lori Passmore and her group have used cryo-electron microscopy to solve the structure of CPF, a protein complex critical for gene expression.
Keywords: Lori Passmore; gene expression; cleavage and polyadenylation factor (CPF); protein; mRNA; ‘poly-A tail’; influenza; virus
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