Author: Devlin, Hannah; Davis, Nicola
Title: Nobel prize in chemistry awarded for method to visualise biomolecules
Reference The Guardian 4 October 2017
Year: 2017
Type: Awards & Prizes
Subject: The 2017 Nobel prize in chemistry is awarded to Richard Henderson along with Jacques Dubochet and Joachim Frank for developing the method for generating 3D images of life-building structures
Keywords: Richard Henderson; Jacques Dubochet; Joachim Frank; X-ray crystallography; cryo-electron microscopy (cryo-EM); 3D structure; Venki Ramakrishnan; Royal Society; “visionary”; frozen; Nobel prize
Photographs: Artist image of the three winners; image showing the resolution before cry-EM and after.Author: Cressey, Daniel; Callaway, E.
Title: Cryo-electron microscopy wins chemistry Nobel
Reference Nature 5 October 2017
Year: 2017
Type: Awards & Prizes
Subject: Jacques Dubochet, Joachim Frank and Richard Henderson were awarded the 2017 chemistry Nobel prize for their work in developing cryo-electron microscopy (cryo-EM).
Keywords: Richard Henderson; Jacques Dubochet; Joachim Frank; Nobel prize; chemistry; cryo-microscopy (cryo-EM); X-ray crystallography; Nigel Unwin; 3D structures; Venki Ramakrishnan; Sjors Scheres
Photographs: Portrait images of the three winnersAuthor: Moody, Oliver
Title: Image pioneer wins Nobel chemistry prize
Reference The Times 5 October 2017
Year: 2017
Type: Awards & Prizes
Subject: Richard Henderson along with Jacques Dubochet, Joachim Frank is awarded the 2017 chemistry Nobel prize for their work in developing cryo-electron microscopy (cryo-EM).
Keywords: Richard Henderson; Jacques Dubochet; Joachim Frank; Nobel prize; Chemistry; cryo-electron microscopy (cryo-EM); Venki Ramakrishnan; imaging revolution
Photographs:Author: Medical Research Council News
Title: MRC scientist wins 2017 Nobel Prize in Chemistry
Reference MRC News 4 October 2017
Year: 2017
Type: Awards & Prizes
Subject: Richard Henderson has been awarded the 2017 Nobel Prize in Chemistry, alongside Jacques Dubochet and Joachim Frank
Keywords: Richard Henderson; Nobel prize; chemistry; Jacques Dubochet; Joachim Frank; cryo-electron microscopy (cryo-EM); X-ray crystallography; Nigel Unwin; Hugh Pelham; atomic structure; 3D image
Photographs: Richard Henderson in lab; Richard with model; portrait shot (all MRC LMB images)Author: Brackley, Paul
Title: Another medal for Cambridge’s own Nobel Prize factory
Reference Cambridge Independent 11 October
Year: 2017
Type: Awards & Prizes
Subject: Richard Henderson has been awarded the 2017 Nobel Prize in Chemistry, alongside Jacques Dubochet and Joachim Frank
Keywords: Richard Henderson; Nobel prize; Jacques Dubochet; Joachim Frank; cryo-electron microscopy (cryo-EM); X-ray crystallography; Sjors Scheres; Nigel Unwin; 3D; Hugh Pelham; Fred Sanger
Photographs: Richard in front of Nobel laureates of the LMB banner.Author: Cambridge Independent
Title: £2.1m to help develop drugs that stop cancer cells growing
Reference Cambridge Independent 23 August 2017
Year: 2017
Type: Funding
Subject: David Barford will lead a five-year project that aims to identify and develop potential new drugs to stop cancer cells growing.
Keywords: David Barford; APC/C complex; grant; Cancer Research UK; drug compounds; cancer cells; funding; Science Committee Programme Awards
Photographs: David Barford head shotAuthor: Cambridge News
Title: Breakthrough could lead to new Alzheimer’s treatment
Reference Cambridge News 7 July 2017
Year: 2017
Type: Science
Subject: Michel Goedert and Sjors Scheres lead research on Alzheimer’s using cryo-EM to give the first close up image of tangled proteins in the brain.
Keywords: Michel Goedert; Sjors Scheres; Alzheimer’s; tau tangles; neurodegenerative disease; cryo-electron microscopy; protein; filaments; transport system
Photographs:Author: von Radowitz, John
Title: Image of tangled brain protein may help to treat Alzheimer’s
Reference (i) 6 July 2017
Year: 2017
Type: Science
Subject: Michel Goedert leads research on Alzheimer’s using cryo-EM to give the first close up image of tangled proteins in the brain.
Keywords: Michel Goedert; tau tangles; Alzheimer’s; cryo-electron microscopy; filaments; protein; transport system
Photographs:Author: Brackley, Paul
Title: Youth champion among those in Queen’s Birthday Honours
Reference Cambridge Independent 21 June 2017
Year: 2017
Type: Awards & Prizes
Subject: John Sulston made Companion of Honour for “services to science and society” in the Queen’s Birthday Honours
Keywords: John Sulston; Queen’s Birthday Honours; human genome; sequencing; Sydney Brenner; Robert Horvitz; Sanger Institute; Companion of Honour
Photographs:Author: Brackley, Paul; Comber, Ben
Title: City’s Brexit brain drain warning to government
Reference Cambridge Independent 5 July 2017
Year: 2017
Type: Miscellaneous
Subject: Daniel Zeichner visits the LMB and hears about the importance of EU Nationals
Keywords: Daniel Zeichner; ‘Nobel Prize factory’; Hugh Pelham; Brexit; EU; funding; brain drain
Photographs: Hugh with Daniel Zeichner in a labAuthor: Cambridge News
Title: Working together on ‘Nobel factory’
Reference Cambridge News 5 March 2013
Year: 2013
Type: Architecture and Buildings
Subject: New LMB building and the teamwork of Cambridge-based firms that helped to get the building built.
Keywords: Cambridge Biomedical Campus; ‘Nobel Prize factory’; Addenbrooke’s 2020 vision; £212 million; Januarys, Dodson Jones; Hewitsons; new building
Photographs: Outside shot of new buildingAuthor: Brackley, Paul
Title: Family-friendly open day at world-famous Laboratory for Molecular Biology in Cambridge will offer amazing insight
Reference Cambridge Independent 16 June 2017
Year: 2017
Type: Events and Celebrations
Subject: 2017 sees the LMB open its doors to the public and offer activities and talks about the work that takes place at the lab.
Keywords: Open day; ‘Nobel Prize factory’; Cambridge Biomedical Campus;
Photographs: Simon Bullock in lab; Charlie Morgan; Image of the atrium from 2013 open dayAuthor: Fyfe, Ian
Title: Tau pathology in atomic detail
Reference Nature Reviews Neurology 21 July 2017
Year: 2017
Type: Science
Subject: Michel Goedert and Sjors Scheres lead research on Alzheimer’s using cryo-EM to give the first close up image of tangled proteins in the brain.
Keywords: tau filaments; Alzheimer’s Disease; Michel Goedert; Sjors Scheres; cryo-EM; myloid-β; α-synuclein; prions; X-ray crystallography; 3D crystals
Photographs:Author: MRC News
Title: Toxic formaldehyde is produced inside our own cells, scientists discover
Reference MRC News 17 August 2017
Year: 2017
Type: Science
Subject: New research involving KJ Patel revealed that most of the toxin formaldehyde in our bodies does not come from our environment – it is a by- product of essential reactions inside our own cells.
Keywords: Ketan Patel; toxic formaldehyde; folate; BRCA1; BRCA2; cancer; one-carbon cycle; formate
Photographs:Author: Kramer, Katrina
Title: The birth of the cool. Super cool microscopy wins the 2017 Nobel prize in chemistry
Reference Chemistry World 13 October 2017
Year: 2017
Type: Awards & Prizes
Subject: Richard Henderson talks about the development of cryo-EM that led to him sharing the 2017 Nobel prize for chemistry
Keywords: Richard Henderson; Nigel Unwin; Sjors Scheres; X-ray crystallography; Cryo-EM; 3D crystal; bacteriorhodopsin; Lori Passmore; ‘blobology era’
Photographs: Richard with model of bacteriorhodopsin.Author: Cancer Research UK
Title: Researchers “drug the undruggable” through unique collaboration
Reference Cancer Research UK 18 October 2017
Year: 2017
Type: Science
Subject: A new approach to targeting key cancer-linked proteins, thought to be ‘undruggable’, has been discovered through an alliance between industry and academia created by Cancer Research UK. David Komander’s group is one of the groups involved in this unique collaboration.
Keywords: David Komander; p53; ubiquitin-proteasome system; USP7; ‘undruggable’; cancer;
Photographs:Author: Nicodemo, Allie
Title: Northeastern researchers discover fundamental rules for how the brain controls movement
Reference News @ Northeastern 23 October 2017
Year: 2017
Type: Science
Subject: Research published in Nature, describes for the first time the ability to predict, test, and confirm with unprecedented detail how a nematode’s brain controls the way it moves. Colleagues from Bill Schafer’s group tested the predictions by killing individual neurons from the nematode brain with a laser.
Keywords: Emma Towlson; Northeastern; “microsurgeries”; William Schafer; nematode brain; neurons; body movement; muscle; laser;
Photographs: Emma Towlson, Postdoc at the Center for Complex Network Science ResearchAuthor: Chicurel, Marina
Title: PINK1 Caught on the Brink of Phosporylation
Reference ALZFORUM 3 November 2017
Year: 2017
Type: Science
Subject: Researchers have caught a rare view of an unusual kinase poised to phosphorylate its substrate. Led by David Komander,, the researchers reported the crystal structure of the kinase PINK1 bound to ubiquitin
Keywords: David Komander; PINK1; phosphorylate; pre-catalytic state; Alexander Schubert; Pediculus humanus corporis (body louse); E-coli; T66V; L67N; Ub TVLN; WT ubiquitin; N-lobe; Parkinsonism; mutations; kinase; ATP; Parkin; Ser65; “insertions”
Photographs:Author: Kassam, Zara
Title: Cryo-electron microscopy used to identify CPF protein structure
Reference Drug Target Review 30 October 2017
Year: 2017
Type: Science
Subject: Lori Passmore and her group have used cryo-electron microscopy to solve the structure of CPF, a protein complex critical for gene expression.
Keywords: Lori Passmore; gene expression; cleavage and polyadenylation factor (CPF); protein; mRNA; ‘poly-A tail’; influenza; virus
Photographs:Author: Gallagher, James
Title: Daytime wounds ‘heal more quickly’
Reference BBC News 9 November 2017
Year: 2017
Type: Science
Subject: A new study led by John O’Neill and Ned Hoyle shows how bodyclocks in skin cells influence wound healing.
Keywords: John O’Neill; fibroblasts; "chronotype"; “circadian rhythms”; wounds; healing; body clock; daytime; repair
Photographs:Author: Biomaker
Title: Biomaker Fayre showcases 40 open source, low-cost biological instruments
Reference Biomaker 3 November 2017
Year: 2017
Type: Awards & Prizes
Subject: The LMB’s Wolfgang Schmied, in collaboration with Stéphanie Polderdijk from the Cambridge Institute for Medical Research, won ‘Best Technology’ prize in the 2017 Biomaker Challenge for developing a low-cost chromatography system for protein purification
Keywords: Wolfgang Schmied; chromatography; protein purification; 2017 Biomaker Challenge; Department of Engineering; 3D-printing; Stéphanie Polderdijk; 3D-printed award
Photographs: Wolfgang Schmied; Stéphanie Polderdijk with their low-cost chromatography system for protein purificationAuthor: Off the Bench
Title: What Makes us Human?
Reference 17 November 2017
Year: 2017
Type: Science
Subject: Madeline Lancaster, has developed a technique allowing her to create mini brains from cell cultures. These are enabing Madeline and her team to tackle the age-old question: what is it that distinguishes us as humans?
Keywords: Madeline Lancaster; organoids; brain tissue; pluripotent stem cells; choroid plexus; cerebral cortex; hippocampus; neurons; microcephaly; human; mini brains
Photographs: Madeline in the Lab; portrait of Madeline in libraryAuthor: NewsWise
Title: First Atomic Structure From UTSW’s Cryo-EM Facility
Reference NewsWise 12 October 2017
Year: 2017
Type: Alumni
Subject: UT Southwestern Medical Center researchers have published a 3-D atomic structure of the ion channel found in mammals that is implicated in a rare, inherited neurodegenerative disease in humans. Xiaochen Bai, the study’s second corresponding author, spent five years training at LMB
Keywords: Alumni; Cryo-EM; Xiaochen Bai; transient receptor potential mucolipin 1 (TRPML1); Richard Henderson; Nanodiscs; 3-D Image; proteins; “resolution revolution”; Lysosomes; UT Southwestern Medical Center
Photographs: The UTSW research including Xiaochen BaiAuthor: MRC News
Title: Our body clocks cause wounds sustained at night to heal more slowly
Reference MRC News 8 November 2017
Year: 2017
Type: Science
Subject: A new study by John O’Neill’s group has discovered how our body clocks cause wounds, such as cuts and burns, to heal approximately 60% faster if the injury happens during the day rather than at night.
Keywords: John O’Neill; body clock; circadian rhythm; fibroblasts; keratinocytes; healing; burn injuries; repair; daytime; Ned Hoyle
Photographs:Author: MRC News
Title: MRC researchers win prestigious awards for contribution to neurodegeneration research
Reference MRC News 17 August 2017
Year: 2017
Type: Awards & Prizes
Subject: How Michel Goedert’s work has helped in identifying key genetic mutations contributing to neurodegeneration, and transformed our understanding of the mechanisms of neurodegeneration.
Keywords: Michel Goedert; “tangles”; “plaques”; beta amyloid; Alzheimer’s disease; European Grand Prix; mutation; tau gene; neurodegeneration; Royal Society
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