Author: ALZFORUM
Title: Traumatic Tau: Filaments from CTE Share Distinct Structure
Reference ALZFORUM 21 March 2019
Year: 2019
Type: Science
Subject: Researchers in Michel Goedert’s and Sjors Scheres’ groups have revealed the structure of tau filaments from the head injury-associated neurodegenerative disease chronic traumatic encephalopathy
Keywords: Michel Goedert; Sjors Scheres; chronic traumatic encephalopathy (CTE); Tau filaments; Alzheimer’s disease; “punch-drunk syndrome”; neurodegenerative; Pick’s disease; cryo-EM; Benjamin Falcon; boxers; American Football player
Photographs:Author: Botelho, Alyssa
Title: Life In Brief - Sydney Brenner Microbiologist
Reference The i reported from The Washington Post 15 April 2019
Year: 2019
Type: Alumni - Obituary
Subject: Obituary for Sydney Brenner that appeared in The Washington Post
Keywords: Sydney Brenner; ‘The Science of Life’; Francis Crick; ; C. elegans; John Sulston; H Robert Horvitz; Human Genome Project
Photographs: Sydney giving a lectureAuthor: MRC Network News
Title: Inside the ‘Nobel Prize factory’ of the future
Reference MRC Network News Spring 2013
Year: 2013
Type: Architecture and Buildings
Subject: Move from the old LMB building to new site ahead of the official opening in Spring 2013
Keywords: New building; £212m; X-shaped; ‘Nobel Prize factory’; Brad Amos; “interstitial” spaces
Photographs: Atrium of new building (LMB photo)Author: MRC Network
Title: Winter’s wonder
Reference MRC Network Spring 2013
Year: 2013
Type: Awards & Prizes
Subject: Sir Greg Winter is the co-winner of the MRC Millennium Medal for 2013.
Keywords: Greg Winter; monoclonal antibody therapies; lymphoma; Campath-1H; ‘humanised’; Humira; Herceptin; César Milstein; Georges Köhler; ‘scaffold’; Cambridge Antibody Technology (CAT); Domantis; Bicycle Therapeutics; mini-antibodies; AstraZeneca; GlaxoSmithKline
Photographs:Author: MRC Network
Title: Explore Milstein’s healthcare revolution
Reference MRC Network Spring 2013
Year: 2013
Type: Events and Celebrations
Subject: Part of the MRC Centenary programme an online exhibition was launched about the enormous contributions to modern healthcare by LMB Scientist César Milstein.
Keywords: César Milstein; Georges Köhler; monoclonal antibodies; Greg Winter; cancer; arthritis; Lara Marks; exhibition
Photographs: César and his wife Celia in Argentina in 1950sAuthor: MRC Life
Title: Electron microscopy medal for LMB scientist
Reference MRC Life October/November 2018
Year: 2018
Type: Awards & Prizes
Subject: Wanda Kukulski of Cell Biology Division has been awarded the Royal Microscopical Society’s Alan Agar Medal for Electron Microscopy for 2019
Keywords: Wanda Kukulski; Alan Agar Medal; Electron Microscopy; Cell Biology; physical; life sciences; Royal Microscopical Society
Photographs: Wanda in lab (LMB photo)Author: MRC life
Title: MRC scientist shares Nobel Prize in Chemistry
Reference MRC life December 2018/January 2019
Year: 2018
Type: Awards & Prizes
Subject: Greg Winter was awarded a share of the Nobel Prize in Chemistry for his work on phage display of peptides and antibodies
Keywords: Greg Winter; monoclonal antibodies; Nobel Prize; therapies; cancer; arthritis
Photographs: Greg with leading health sign (LMB photo)Author: Carr, Cella
Title: 2019 alumni awards
Reference EMBL etc Alumni 21 February 219
Year: 2019
Type: Alumni - Awards & Prizes
Subject: Tanmay Bharat, a former post-doctoral researcher in Jan Löwe’s group, and previously a PhD student with John Briggs at EMBL, wins for his novel applications of electron cryo-tomography in visualising the molecular structures of bacterial biofilms
Keywords: Tanmay Bharat; EMBL alumni; John Kendrew award; cryo-electron tomography; structural biology; cryo-EM; bacteria; John Briggs; Jan Löwe; Sjors Scheres; infection; biofilm
Photographs: Tanmay Bharat, head shotAuthor: The Francis Crick Institute
Title: Introducing Rupert Beale, clinical researcher
Reference The Francis Crick Institute 23 April 2019
Year: 2019
Type: Alumni - Career Structure
Subject: Rupert Beale, a former PhD student with Michael Neuberger and post-doctoral researcher working with Felix Randow, is profiled as the first clinical early-career group leader at the Francis Crick Institute
Keywords: Rupert Beale; Michael Neuberger; Felix Randow; virology; antibacterial; autophagy; bacteria; cell biology; Francis Crick Institute
Photographs: Rupert Beale at The CrickAuthor: Cambridge Institute for Medical Research (CIMR)
Title: A new Director for the CIMR
Reference CIMR 24 April 2019
Year: 2019
Type: Alumni - Career Structure
Subject: Julian Rayner, a former PhD student in Hugh Pelham’s group in the LMB’s Cell Biology Division, will become the fourth Director of the Cambridge Institute of Medical Research
Keywords: Julian Rayner; Cambridge Institute of Medical Research (CIMR); cell biology; Sanger Intitute; Plasmodium parasites; genomics
Photographs: Julian Rayner in officeAuthor: Skehel, Mark
Title: Working life: technology specialist Mark Skehel
Reference MRC News 4 April 2019
Year: 2019
Type: Career Structure
Subject: Hear career inspirations from Mark Skehel, Head of Mass Spectrometry & Proteomics at the LMB, in the latest ‘MRC talks’ podcast episode. Mark describes his career spanning industry and academia, and how he’s benefited from embracing change
Keywords: Mark Skehel; mass spectrometry; John Walker; Edman sequencer; Proteomics; proteins
Photographs: Mark Skehel in his labAuthor: MRC Life
Title: Jason Chin awarded Sackler Prize
Reference MRC Life April/May 2019
Year: 2019
Type: Awards & Prizes
Subject: Jason Chin joint head of PNAC has been awarded the $100,000 Raymond and Beverly Sackler International Prize in the Physical Sciences
Keywords: Jason Chin; award; Sackler Prize; advancing non-natural amino acid technology; biological discovery; $100,000
Photographs: Jason Chin in lab (LMB photo)Author: MRC Life
Title: RNA Society/Scaringe Graduate Student Award for Max Wilkinson
Reference MRC Life April/May 2019
Year: 2019
Type: Awards & Prizes
Subject: Max Wilkinson a graduate student in Kiyoshi Nagai’s group is one of the winners of the RNA Society/Scaringe Graduate Student Awards
Keywords: Max Wilkinson; RNA Society/Scaringe Graduate Student Awards; young investigators; spliceosome; Kiyoshi Nagai
Photographs: Max Wilkinson in lab (LMB photo)Author: Network
Title: Queen’s Birthday Honours 2018/Royal recognition for Nobel Prize-winner
Reference Network Autumn 2018
Year: 2018
Type: Awards & Prizes
Subject: Richard Henderson is made a Companion of Honour in the 2018 Queen’s Birthday Honours
Keywords: Richard Henderson; Companion of Honour; cryo-electron microscopy (cryo-EM); Queen’s Birthday Honours; services to science; prestigious award; 65 people
Photographs: Richard Henderson in office holding scientific modelAuthor: Network
Title: Discovery of key component of HIV virus yields new drug target
Reference Network 10 August 2016/Autumn 2016
Year: 2016
Type: Science
Subject: A weakness detected in HIV’s protective shell by scientist at the LMB could lead to new drug target and the re-evaluation of existing HIV treatment
Keywords: HIV virus; retrovirus; nucleotides; hexacarboxybenzene; Leo James; David Jacques; immune system; inhibitor; protein shell; capsid; antiviral drugs
Photographs:Author: Wilson, Michele
Title: Your Body Clock Cares About When You Eat
Reference Drug Discovery 25 April 2019
Year: 2019
Type: Science
Subject: John O’Neill’s group have identified insulin as a primary signal that synchronises the body’s circadian rhythm in response to meal times
Keywords: John O’Neill; circadian rhythm; jet lag; “grogginess”; fruit flies; insulin; mTOR signaling; PTEN
Photographs:Author: Brackley, Paul
Title: 365 project captures life and work at MRC Laboratory of Molecular Biology in pictures
Reference Cambridge Independent 21 May 2019
Year: 2019
Type: Events and Celebrations
Subject: Throughout 2019, the LMB posted an image a day on its website and social media channels about life and work at the LMB, both now and in the past.
Keywords: Images; social media; beauty of science; Alex Bates; ‘instinct centre’; Katja Roeper; Drosophilia; reflection; AstraZeneca; Laura Pellegrini; human cerebral organoid; ‘mini brains’; cheese scones; LMB mascot; the LMBee; spinning centrifuse; view of building; cyclepath; Technical Instrumentation Workshop; 3D printed model; openSPIM light sheet microscope; Light Microscopy; nematode worm; C. elegans green fluorescence; aluminium holders; Lego model; Bob Senior KJ Tait; LMBeekeeper; honeybees; reproduction DNA model
Photographs: 365 images from day 6, 9, 14, 16, 30, 32, 35, 50, 52, 54, 57, 64, 97, 105, 112, 155Author: Brackley, Paul
Title: Rising star Dr Ben Falcon at MRC LMB explores role of tau in dementia
Reference Cambridge Independent 22 May 2019
Year: 2019
Type: Science
Subject: Benjamin Falcon, Neurobiology Division, talks to the Cambridge Independent about his work on the structures of tau filaments in different types of dementia after winning the Alzheimer’s Research UK Rising Star Award for his work in this area
Keywords: Ben Falcon; Michel Goedert; Sjors Scheres; tau filaments, dementia; Alzheimer’s, Pick’s disease; chronic traumatic encephalopathy (CTE); toxic; neurodegeneration; filament structure; C-shape; J-shape; contact sports; boxers; American football player; Richard Henderson; cryo-electron microscopy (cryo-EM); cortical sulci; blood vessel; aggregates
Photographs: Ben Falcon in lab; The structure of tau aggregatesAuthor: Tafilaku, Jonida
Title: Taking science from the bench to policy change
Reference MRC Insight blog 17 July 2019
Year: 2019
Type: Career Structure
Subject: Jonida Tafilaku, PhD student at the LMB, spoke to the MRC about her time as an intern at the Parliamentary Office of Science and Technology.
Keywords: Jonida Tafilaku, Parliamentary Office of Science and Technology (POST); UKRI Policy Internships Scheme; producing reports; climate change; mosquitoes; policy-making; science writing; politicians; PhD student
Photographs: Jonida in the lab (arms crossed)Author: Brackley, Paul
Title: MRC LMB’s Michel Goedert receives Royal Society’s 2019 Royal Medal for his neurodegenerative disease work
Reference Cambridge Independent 25 July 2019
Year: 2019
Type: Awards & Prizes
Subject: For identifying and characterising key molecules that form the inclusions of Alzheimer’s and Parkinson’s diseases, Michel Goedert was awarded this year’s prestigious Royal Medal
Keywords: Michel Goedert; Royal Society; Royal Medal; neurodegenerative disease; Alzheimer’s; Parkinson’s; award; Aaron Klug; pathological pathways; Tau protein; filaments; tangles; Lewy bodies; Sjors Scheres; Jan Löwe; protein alpha-synuclein; Venki Ramakrishnan
Photographs: Two photos of Michel taken in the building (Keith Heppell, Cam indp)Author: Highfield, Roger
Title: Weird synthetic proteins could let us build new kinds of life
Reference Wired 26 August 2019
Year: 2019
Type: Science
Subject: Article on Jason Chin and his team’s work focusing on “turbocharging the ribosome”. Jason explains the process behind evolving new ribosomes and it marks a revolution in our ability to evolve, manufacture and discover polymer sequences
Keywords: Jason Chin; amino acids; proteins; canonical 20; synthesise polymers; ribosome; RNA; 3D proteins; beneficial mutations; ‘orthogonal ribosome’; turbocharging; genetic code; codons; gene therapy; chemical units
Photographs:Author: The Economist
Title: What is a brain? Cerebral organoids are becoming more brainlike
Reference The Economist 29 August 2019
Year: 2019
Type: Science
Subject: The Economist draws on the evolution of the first cerebral organoids in Madeline Lancaster’s lab in 2013 to today’s research on electrical impulses from these mini brains
Keywords: Madeline Lancaster; “cerebral organoid’; pluripotent human stem cells; embryonic; Alysson Muotri; neurons; electrical pulsing; synchronised
Photographs:Author: Geddes, Linda
Title: What is the worst time of the day to get sick?
Reference BBC Future 5 September 2019
Year: 2019
Type: Science
Subject: The role circadian rhythms plays in how our bodies respond to injuries, infections and healing, including work by John O’Neill’s group on tissue repair damage and biological time
Keywords: John O’ Neill; body clock; immune system; “circadian rhythm”; healing; ebb and flow; fibroblasts; biological time; infection; chronotherapy; synchronised; Tami Martino; surgery; tissue repair; injury
Photographs: Images of flu jab and hospitalAuthor: Newsdesk
Title: Finalist in the 2019 Cambridge Independent Science and Technology Awards revealed
Reference Cambridge Independent 13 September 2019
Year: 2019
Type: Awards & Prizes
Subject: The Science and Technology Awards, run by Cambridge’s weekly newspaper, feature Benjamin Falcon from Neurobiology Division and Julius Fredens from Protein and Nucleic Acid Division as finalists
Keywords: Cambridge Independent Science and Technology Awards; Researcher of the Year; Ben Falcon; Michel Goedert; tau filaments; dementia; cryo-EM; Julius Fredens; Jason Chin; genome; E. coli; synthesised; codons; finalist
Photographs: Ben Falcon in labAuthor: Neuronet
Title: Spotlight on early-career investigators: an interview with Benjamin Falcon
Reference Neuronet 17 September 2019
Year: 2019
Type: Career Structure
Subject: Newly recruited Group Leader weighs in on various aspects of Alzheimer’s Disease, from the clinical implications of deciphering Tau filaments in brains of people suffering from neurodegenerative diseases, to designing precise drugs
Keywords: Ben Falcon; Michel Goedert; Neurodegenerative Disease; protein tau; chronic traumatic encephalopathy (CTE); Alzheimer’s disease; abnormal filaments; cryo-EM; Pick’s disease; IMPRiND; PET ligands; 3D
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