Author: Brackley, Paul
Title: MRC LMB’s Michel Goedert receives Royal Society’s 2019 Royal Medal for his neurodegenerative disease work
Reference Cambridge Independent 25 July 2019
Year: 2019
Type: Awards & Prizes
Subject: For identifying and characterising key molecules that form the inclusions of Alzheimer’s and Parkinson’s diseases, Michel Goedert was awarded this year’s prestigious Royal Medal
Keywords: Michel Goedert; Royal Society; Royal Medal; neurodegenerative disease; Alzheimer’s; Parkinson’s; award; Aaron Klug; pathological pathways; Tau protein; filaments; tangles; Lewy bodies; Sjors Scheres; Jan Löwe; protein alpha-synuclein; Venki Ramakrishnan
Photographs: Two photos of Michel taken in the building (Keith Heppell, Cam indp)Author: Highfield, Roger
Title: Weird synthetic proteins could let us build new kinds of life
Reference Wired 26 August 2019
Year: 2019
Type: Science
Subject: Article on Jason Chin and his team’s work focusing on “turbocharging the ribosome”. Jason explains the process behind evolving new ribosomes and it marks a revolution in our ability to evolve, manufacture and discover polymer sequences
Keywords: Jason Chin; amino acids; proteins; canonical 20; synthesise polymers; ribosome; RNA; 3D proteins; beneficial mutations; ‘orthogonal ribosome’; turbocharging; genetic code; codons; gene therapy; chemical units
Photographs:Author: The Economist
Title: What is a brain? Cerebral organoids are becoming more brainlike
Reference The Economist 29 August 2019
Year: 2019
Type: Science
Subject: The Economist draws on the evolution of the first cerebral organoids in Madeline Lancaster’s lab in 2013 to today’s research on electrical impulses from these mini brains
Keywords: Madeline Lancaster; “cerebral organoid’; pluripotent human stem cells; embryonic; Alysson Muotri; neurons; electrical pulsing; synchronised
Photographs:Author: Geddes, Linda
Title: What is the worst time of the day to get sick?
Reference BBC Future 5 September 2019
Year: 2019
Type: Science
Subject: The role circadian rhythms plays in how our bodies respond to injuries, infections and healing, including work by John O’Neill’s group on tissue repair damage and biological time
Keywords: John O’ Neill; body clock; immune system; “circadian rhythm”; healing; ebb and flow; fibroblasts; biological time; infection; chronotherapy; synchronised; Tami Martino; surgery; tissue repair; injury
Photographs: Images of flu jab and hospitalAuthor: Newsdesk
Title: Finalist in the 2019 Cambridge Independent Science and Technology Awards revealed
Reference Cambridge Independent 13 September 2019
Year: 2019
Type: Awards & Prizes
Subject: The Science and Technology Awards, run by Cambridge’s weekly newspaper, feature Benjamin Falcon from Neurobiology Division and Julius Fredens from Protein and Nucleic Acid Division as finalists
Keywords: Cambridge Independent Science and Technology Awards; Researcher of the Year; Ben Falcon; Michel Goedert; tau filaments; dementia; cryo-EM; Julius Fredens; Jason Chin; genome; E. coli; synthesised; codons; finalist
Photographs: Ben Falcon in labAuthor: Neuronet
Title: Spotlight on early-career investigators: an interview with Benjamin Falcon
Reference Neuronet 17 September 2019
Year: 2019
Type: Career Structure
Subject: Newly recruited Group Leader weighs in on various aspects of Alzheimer’s Disease, from the clinical implications of deciphering Tau filaments in brains of people suffering from neurodegenerative diseases, to designing precise drugs
Keywords: Ben Falcon; Michel Goedert; Neurodegenerative Disease; protein tau; chronic traumatic encephalopathy (CTE); Alzheimer’s disease; abnormal filaments; cryo-EM; Pick’s disease; IMPRiND; PET ligands; 3D
Photographs:Author: Dhillon, Paraminder
Title: In conversation with Greg Winter
Reference The FEBS Journal 11 October 2019
Year: 2019
Type: History - Reminiscences
Subject: Greg discusses his early motivations, monoclonal antibody therapy research, life after the Nobel prize, and balancing entrepreneurship with science.
Keywords: Greg Winter; human therapeutic antibodies; Biotech companies; Cambridge Antibody Technology; Bicycle Therapeutics; ‘humanise’; mouse; auto-immune diseases; Nobel Prize; Trinity College; phage; antigen; ‘eureka’; clone; monoclonal; Christian Heinis; Brexit; Brian Hartley; Cesar Milstein;
Photographs: Greg Winter at the 2018 Nobel Prize Award Ceremony; Greg in 1990s with on antibody libraries (MRC-LMB)Author: Rajewsky, Klaus
Title: The advent and rise of monoclonal antibodies
Reference Nature 7 November 2019
Year: 2019
Type: History - Reminiscences
Subject: Opinion piece recounts the dramatic impact of the pivotal 1975 paper by Köhler–Milstein on biomedical and, specifically, immunological research, which was propelled by scientific developments that occurred around the time the paper appeared
Keywords: Georges Köhler; César Milstein; monoclonal antibodies; immunized mouse; antigen; hybridomas; therapeutic; somatic hypermutation; gene-expression; ‘barcoded’; ligand-binding
Photographs: The production of monoclonal antibodies diagramAuthor: Brackley, Paul
Title: LMB unveils vision for next generation of Nobel Prize-winning cryo-EM technology
Reference Cambridge Independent 13 November 2019
Year: 2019
Type: Science
Subject: Chris Russo, Katerina Naydenova and Greg McMullan discuss the latest developments in the field of cryo-EM with Paul Brackley of the Cambridge Independent
Keywords: Cryo-EM; Richard Henderson; Titan Krios microscopes; Chris Russo; Mathew Peet; electron beam; X-ray crystallography; aqueous solution; 3D; Greg McMullan; hybrid-pixel detector; field emission gun (FEG); Katerina Naydenova
Photographs: Chris Russo with the detector; Katerina Naydenova, Greg McMullan and Chris Russo, A cryo-electron microscopeAuthor: Ferry, Georgina
Title: Cyrus Chothia obituary
Reference The Guardian 12 December 2019
Year: 2019
Type: Obituary
Subject: Georgina Ferry looks back at the life of Cyrus Chothia and the importance of his work in laying the foundations of the field of bioinformatics
Keywords: Cyrus Chothia; Taxonomy; computational analysis; bioinformatics; Arthur Lesk; Immune system; antibody structures; Structural Classification of Proteins (SCOP); database; Dan David Prize; ‘theoretical and computation biology”
Photographs: Cyrus Chothia in 2015Author: UKRI MRC News
Title: Slashing energy could make Nobel Pize-winning cryoEM microscopes more affordable
Reference UKRI - MRC News 2 January 2020
Year: 2020
Type: Science
Subject: Proof-of-principle research led by Chris Russo showing that cryo-EM could be made 10 times cheaper
Keywords: Electron cryomicoscopy (CryoEM); cheaper; cost; Chris Russo; Richard Henderson; ‘hybrid pixel detector’; energy; electron beam; 3D structure
Photographs:Author: Lawrence, Peter. A
Title: Sydney Brenner: a master of science and wit
Reference The Company of Biologists 9 May 2019
Year: 2019
Type: Alumni - Obituary
Subject: Emeritus Group Leader Peter Lawrence shares a selection of Sydney Brenner’s deep and original insights into biology and genetics, alongside many brilliant quotes that display his unique wit.
Keywords: Sydney Brenner; Oscar Wilde; Francis Crick; alumni; obituary; genetics; c. elegans; nematode
Photographs: Sydney as young man (CSHL Archives)Author: Gonville & Caius
Title: Professor Michael Levitt honoured at Honorary Degree Congregation
Reference Gonville & Caius 19 June 2019
Year: 2019
Type: Alumni - Awards & Prizes
Subject: Michael Levitt, a former PhD student and staff scientist, is one of eight distinguished nominees to receive an Honorary Doctorate from the University of Cambridge at a ceremony in Senate House
Keywords: Michael Levitt; Gonville & Caius; Senate House; Honorary Degree; Alan Fersht; Award; Alumni; Structural Studies
Photographs:Author: Babraham Institute News
Title: Institute welcomes new group leader
Reference Babraham Institute News 7 August 2019
Year: 2019
Type: Alumni - Career Structure
Subject: The Babraham Institute welcomes Hayley Sharpe, a former PhD student in Sean Munro’s group in the Cell Biology Division, as a new group leader within the Signalling research programme
Keywords: Hayley Sharpe; Babraham Institute; Signalling research programme; Group Leader; Cambridge Institute for Medical Research (CIMR); tyrosine Phosphatases; PTPRK; Sean Munro; Genentech; Alumni
Photographs: Hayley in her lab at BabrahamAuthor: International Biomedical Research Alliance
Title: The Alliance Awards the Gregory Paul Lenardo Basic Science Award to Scholar Nick Ader
Reference International Biomedical Research Alliance 24 September 2019
Year: 2019
Type: Alumni - Awards & Prizes
Subject: The award endowed by NIH Oxford-Cambridge Scholars Program Co-Founder, Michael Lenardo, was given to Nicholas in recognition of his PhD work conducted in Wanda Kukulski’s lab
Keywords: Nick Ader; award; Michael Lenardo; Wanda Kukulski; alumni; Gregory Paul Lenardo; Alliance
Photographs:Author: Lanese, Nicoletta
Title: Johannes Kohl Untangles the Neural Circuitry Behind Instinct
Reference The Scientist 1 October 2019
Year: 2019
Type: Alumni - Science
Subject: Johannes Kohl a former PhD student from Greg Jefferis’ group, aims to learn how physiological states, such as hunger, alter information processing in the brain.
Keywords: Johannes Kohl; Greg Jefferis; Drosophila; fruit flies; D. melanogaster; alumni; cVA; transient physiological
Photographs:Author: D’alessio, Vittoria
Title: New findings about how a human egg matures may help prevent infertility and birth defects
Reference Horizon: The EU Research & Innovation Magazine 15 October 2019
Year: 2019
Type: Alumni - Science
Subject: Melina’s work on mechanisms of chromosome segregation in mammalian oocytes has advanced our understanding the process of meiosis and the causes of aneuploidy in mammalian eggs, including humans
Keywords: Melina Schuh; human egg; genetic errors; Max Planck Institute for Biophysical Chemistry; ChromOocyte; trisomic foetuses; Meiosis; Agata Zielinska; alumni; cohesin; Kinetochores; chromosome; fertility; diploid cell; ‘handles’; spindle; Aneuploidy; infertility
Photographs:Author: Crowther, R.A.
Title: Sir Aaron Klug OM FRS (1926-2018)
Reference Acta Crystallographica Section D, May 2019
Year: 2019
Type: Obituary
Subject: Obituary by Tony Crowther about Aaron Klug who died on 20 November 2018
Keywords: Aaron Klug; X-ray diffraction; ‘The Microbe Hunters”; X-ray crystallography; Rosalind Franklin; Birkbeck College; tobacco mosaic virus (TMV); John Finch; Royal Society; icosahedral viruses; Fourier; Donald Caspar; tRNA; filaments; tangles
Photographs: Aaron (MRC-LMB)Author: Amos, Jonathan
Title: Sydney Brenner: Molecular biology pioneer dies
Reference BBC Science News 5 April 2019
Year: 2019
Type: Alumni - Obituary
Subject: BBC obituary for Sydney Brenner
Keywords: Sydney Brenner; Francis Crick; C.elegans; “code of life”; codons; RNA; James Watson; Linus Pauling; François Jacob; director; genetics
Photographs: Brenner was part of the hothouse environment at LMBAuthor: Kermode-Scott, Barbara
Title: Sydney Brenner: Nobel laureate and molecular biologist who specialised in comparative genomics
Reference The BMJ 30 April 2019
Year: 2019
Type: Alumni - Obituary
Subject: Sydney Brenner obituary in the BMJ
Keywords: Sydney Brenner; genetic code; Francis Crick; C elegans; unit of molecular genetics; mRNA; amino acids; genome
Photographs: Sydney Brenner (older) (not LMB)Author: Rhodes, Daniela
Title: Aaron Klug (1926-2018)
Reference Nature Structural & Molecular Biology 21 January 2019
Year: 2019
Type: Obituary
Subject: Daniela Rhodes obituary for Aaron Klug written for the journal Nature Structural & Molecular Biology
Keywords: Aaron Klug; Knighthood; Rosalind Franklin; Birkbeck College; X-ray crystallography; John Finch; Don Caspar; Fourier; tRNA; amino acids; tobacco mosaic virus (TMV); zinc finger; nucleosome; Yen Choo; Chromatin; crystallographic electron microscopy
Photographs: Aaron with model (LMB)Author: Else, Holly
Title: Scientists among thousands marching to demand say on Brexit
Reference Nature 23 March 2019
Year: 2019
Type: Miscellaneous
Subject: Scientists took to the streets of London as part of a major demonstration calling for the terms of Brexit to be put to the British people for a vote. Stephen McLaughlin from the LMB was among them.
Keywords: Brexit; protest; EU; Stephen McLaughlin; referendum; Venki Ramakrishnan
Photographs:Author: Amos, Brad
Title: Obituary: Christien Merrifield 1972-2017
Reference British Society for Cell Biology 2018
Year: 2018
Type: Obituary
Subject: Obituary for Christien Merrifield who once had a group at the LMB
Keywords: Christien Merrifield; endocytosis; Selwyn Award of the Royal Photographic Society; Optical Insights; Cell Biology of the Royal Photographic Society
Photographs:Author: Department Of Energy Science News
Title: In Memoriam: Thomas Steitz, Nobel Laureate, 78
Reference DOE Science News 7 November 2018
Year: 2018
Type: Alumni - Obituary
Subject: Obituary for Thomas Steitz
Keywords: Thomas Steitz; Robert Sweet; 50S ribosomal subunit; National Synchrotron Light Source (NSLS); Francis Crick; Joan A. Steitz; X-ray crystallography; macromolecular
Photographs:Author: Hand, Eric
Title: ‘We need a people’s cryo-EM.’ Scientists hope to bring revolutionary microscope to the masses
Reference Science 23 January 2020
Year: 2020
Type: Science
Subject: Profiles structural biology scientists at the LMB, including Chris Russo and Nobel Prize winner Richard Henderson, and their work on bringing cryo-EM to hundreds of more labs
Keywords: Richard Henderson; Chris Russo; cryo-EM; X-ray crystallography; 3D structure; affordable; Krios machines; graphene; 100-KeV; flash-freezing; JEOL; microscope; structural biology
Photographs: Richard Henderson (LMB)