Author: Callaway, Ewen
Title: The protein-imaging technique taking over structural biology
Reference Nature 13 February 2020
Year: 2020
Type: Science
Subject: An interview with LMB scientists Richard Henderson and Sjors Scheres. Estimating that by 2024, more protein structures will be determined by cryo-EM than by X-ray crystallography
Keywords: Richard Henderson; Sjors Scheres; cryo-EM; 3D; Electron Microscopy Data Bank (EMDB); X-ray crystallography; flash-freezing; microscope; ‘structure sleuths’
Photographs:Author: Kießling, Tilmann
Title: Eleven researchers receive EMBO Installation Grants to establish independent laboratories
Reference EMBO News 21 January 2020
Year: 2020
Type: Alumni - Funding
Subject: Piotr Szwedziak, a former PhD student and post-doctoral researcher in Jan Löwe’s group, has received an EMBO Installation Grant to establish an independent laboratory and joins the EMBO Young Investigator Network
Keywords: Piotr Szwedziak; alumni; Jan Löwe; Installation Grants; EMBO; Young Investigator Network; funding
Photographs:Author: Crowther, Tony
Title: Sir Aaron Klug OM 11 August 1926 - 20 November 2018
Reference The Royal Society 8 January 2020
Year: 2020
Type: Alumni - Obituary
Subject: Memoir for Aaron Klug written by Tony Crowther for the Royal Society
Keywords: Aaron Klug; Max Perutz; X-ray crystallography; John Finch; Rosalind Franklin; Tobacco Mosaic Virus (TMV); Don Caspar; Ken Holmes; Birkbeck; Michael Rossmann; obituary; Francis Crick; ‘kinky helix’; chromatin; zinc finger; transfer RNA; viruses; Michel Goedart; Tony Crowther; neurodegenerative; Wellcome Sanger Institute; John Sulston; Royal Society; Peterhouse; Brian Clark
Photographs: Portrait of Aaron; Aaron as a child with mother and brother; John Finch, Aaron and Brian Clark with model (MRC LMB); Aaron and Liebe with Prince Claus of the Netherlands; Aaron in his gardenAuthor: Blavatnik Awards for Young Scientists
Title: The Blavatnik Awards for young scientists in Israel celebrates its third year
Reference Blavatnik Awards for Young Scientists 27 January 2020
Year: 2020
Type: Alumni - Awards & Prizes
Subject: The Blavatnik Awards honour outstanding, innovative scientists at the early stages of their careers. Emmanuel Levy has been recognised for his work on protein assembly and organisation
Keywords: The Blavatnik Awards; Israel; Emmanuel Levy; Weizmann Institute of Science; alumni; Young Scientist
Photographs: Small portrait imageAuthor: Vogel, Gretchen
Title: ‘Revolution based on evolution’ honored with chemistry Nobel
Reference Science 3 October 2018
Year: 2018
Type: Awards & Prizes
Subject: Science news article about the winners of the 2018 Nobel prizes in Chemistry which included Greg Winter
Keywords: Greg Winter; Nobel Prize; antibodies; autoimmune diseases; adalimumab; bicycles; therapeutics
Photographs:Author: Gibney, Elizabeth; Van Noorden, Richard; Ledford, Heidi; Castelvecchi, Davide; Warren, Matthew
Title: ‘Test-tube’ evolution wins Chemistry Nobel Prize
Reference Nature news 3 October 2018
Year: 2018
Type: Awards & Prizes
Subject: Frances Arnold, Gregory Winter and George Smith controlled evolution in the lab to produce greener technologies and new medicines
Keywords: Greg Winter; Nobel prize; autoimmune; adalimumab (Humira); antibodies; human therapeutics; Cambridge Antibody Technology
Photographs:Author: Dubach, Isabelle
Title: Breakthrough study shows how HIV is shielded from immune attack
Reference UNSW News 10 July 2018
Year: 2018
Type: Science
Subject: Scientists from UNSW Sydney and the LMB have discovered that the human immunodeficiency virus (HIV) hijacks a small molecule from the host cell to protect itself from being destroyed by the host’s immune system.
Keywords: antiviral therapy; HIV; capsid; Leo James; virus; UNSW;inositol hexakisphosphate
Photographs:Author: Brackley, Paul
Title: Cambridge scientists discover why drinking alcohol increases your risk of cancer
Reference Cambridge Independent 4 January 2018
Year: 2018
Type: Science
Subject: Researchers at the LMB have helped to explain why drinking alcohol increases your risk of cancer
Keywords: Alcohol; cancer; ‘Dry January’; DNA; acetaldehyde; KJ Patel; damage; aldehyde dehydrogenases (ALDH); mutations
Photographs:Author: Brackley, Paul
Title: Crescendo Biologics pioneers a new approach to using antibodies in fight against cancer
Reference Cambridge Independent 23 June 2018
Year: 2018
Type: Biotechnology
Subject: Crescendo Biologics is a company that is taking the early antibody research of Georges Köhler, César Milstein and Greg Winter and applying further innovation to create cancer drugs
Keywords: Crescendo Biologics; Humabody; Humira; Greg Winter; Cambridge Antibody Technology (CAT); Peter Pack; antigens; Fab; ‘humanising’; VH domains; immunogloblins; cancer drugs; Georges Köhler; César Milstein; monoclonal antibodies; Michael Neuberger; Campath; therapeutic
Photographs:Author: The Pelican (Corpus Christi magazine)
Title: Dr Richard Henderson (m1966) Honorary Fellow and Nobel Prize winner
Reference The Pelican 2018
Year: 2018
Type: History - Reminiscences
Subject: Richard Henderson looks back over his life and scientific career
Keywords: Richard Henderson; Max Perutz; John Kendrew; Nigel Unwin; X-ray crystallography; David Blow; chymotrypsin; Director; electron microscopy; Nobel;
Photographs: Two images of Richard holding models; Richard receiving the Nobel PrizeAuthor: Guyoncourt, Sally
Title: ‘Drinking alcohol damages DNA and raises cancer risk’
Reference The i 4 January 2018
Year: 2018
Type: Science
Subject: KJ Patel has led a study into how drinking alcohol increases your risk of cancer
Keywords: KJ Patel; cancer; DNA; ethanol; damage; alcohol; acetaldehyde
Photographs:Author: Sansom, Clare
Title: A splice of life
Reference Chemistry World 23 March 2020
Year: 2020
Type: Science
Subject: History of spliceosome research and its importance, focusing on the work of Kiyoshi Nagai and his group.
Keywords: Human Genome Project; RNA; eukaryotes; Kiyoshi Nagai; Max Perutz; “Nobel Prize factory’; Chris Oubridge; Aaron Klug; haemoglobin; sliceosome; snRNPS (‘snurps’); Shaoxia Chen; Krios; introns; splicing; spinal muscular atrophy (SMA); X-ray crystallography
Photographs:Author: Brackley, Paul
Title: Are some people at greater genetic risk from Covid-19? MRC Laboratory of Molecular Biology seeks DNA volunteers
Reference Cambridge Independent 15 May 2020
Year: 2020
Type: Science
Subject: Cambridge Independent feature story on Julian Gough’s new phenotype prediction genome data study, which is also exploring whether DNA genotype can be used to predict Covid-19 risk factors. Julian is asking those who have had consumer DNA tests to aid the research by volunteering their data
Keywords: Covid-19; Julian Gough; 23andMe; AncestryDNA; genotype; risk factors; genetic; coronavirus; SARS-CoV-2 virus; ACE2 gene; immune system; BAME; ethnic groups
Photographs: Julian Gough in the lab (MRC LMB)Author: Highfield, Roger
Title: Coronavirus: How the virus works
Reference Science Museum Group 22 May 2020
Year: 2020
Type: Science
Subject: Science Museum blog: The development of COVID-19 treatments, tests, drugs and vaccines will be accelerated by molecular understanding of the COVID-19 virus. Roger Highfield, Science Director, looks at what is happening in the LMB
Keywords: COVID-19; SARS-CoV-2; Yorgo Modis; ‘Nobel prize factory’; virus; coronavirus; electron microscopy; Richard Henderson; cryo-EM; X-ray crystallography; John Briggs; Andrew Carter; Leo James; Sjors Scheres; cells; ‘non-structural protein’ (NSP); RNA; Sean Munro; ACE2; spike; polyprotein; Julian Sale; immune response; Jan Löwe; Radu Aricescu; Harvey McMahon; David Barford; John Sutherland; antibodies; Avigan; Remdesivir; Chris Oubridge; Felix Randow; Lori Passmore; Venki Ramakrishnan; Phil Holliger; phages; Madeline Lancaster; ‘mini brains’; organoids; Julian Gough; risk factors; genetics; genotype; protein reagents
Photographs:Author: The American Philosophical Society
Title: The American Philosophical Society Welcomes New Members for 2020
Reference The American Philosophical Society blog 5 May 2020
Year: 2020
Type: Awards & Prizes
Subject: The American Philosophical Society welcomes Venki Ramakrishnan as a new 2020 Member elected to the Society
Keywords: The American Philosophical Society; Venki Ramakrishnan; member
Photographs:Author: Callaway, Ewen
Title: Revolutionary Microscopy Technique Sees Individual Atoms
Reference Nature 4 June 2020
Year: 2020
Type: Science
Subject: Sjors Scheres’ and Radu Aricescu’s groups have pushed the boundaries of cryo-EM, allowing the technique to detect individual atoms in a protein for the first time
Keywords: cryo-EM; Sjors Scheres; Radu Aricescu; X-ray crystallography; histamine; 3D
Photographs:Author: Vienna BioCenter
Title: Researchers develop “quick and easy” Covid-19 test for population screening with simple means
Reference Vienna BioCenter 24 June 2020
Year: 2020
Type: Science
Subject: Max Kellner, a PhD student in Madeline Lancaster’s group, was stranded in Vienna as much of Europe went into lockdown at the start of the pandemic, but was able to join the Vienna COVID-19 Diagnostics Initiative
Keywords: SARS-CoV-2; Vienna BioCenter; Covid-19; Max Kellner; test; RT-LAMP; lockdown; VCDI (Vienna Covid-19 Diagnostics Initiative); rapid; screening
Photographs: Max Kellner with researchers from other institutes who joined together to develop the testAuthor: Keane, Sarah
Title: Dr. Kelly Nguyen
Reference RNA Society 3 July 2020
Year: 2020
Type: Career Structure
Subject: RNA Society Spotlight has a feature on Kelly Nguyen, a Group Leader in the Structural Studies Division. Kelly describes the inspirations that led to her working in RNA structural biology, her experience of starting her group, and her advice for younger scientists
Keywords: Kelly Nguyen; Tom Steitz; Kiyoshi Nagai; Jade Li; cryo-EM; telomerase structure; mentor; Davos; RNA Society
Photographs: Kelly in the lab (MRC LMB)Author: Brackley, Paul
Title: The origin of life on Earth explored at MRC LMB in Cambridge using a flask and a lamp
Reference Cambridge Independent 3 July 2020
Year: 2020
Type: Science
Subject: Nicholas Green is interviewed in the Cambridge Independent about John Sutherland’s group’s recent research suggesting that DNA and RNA building blocks might have co-existed at the dawn of life
Keywords: UV lamp; primordial soup; Nicholas Green; Jianfeng Xu; Václav Chmela; David Russell; John Sutherland; amino acids; RNA; flasks; Earth; synthetic biology; artificial life
Photographs: John Sutherland’s group outside the from of the buildingAuthor: Chalmers, Vanessa
Title: Scientists create a drug that ‘repairs damage to the brain and spinal cord’ in potential breakthrough for paralysed patients and Alzheimer’s sufferers
Reference Mail Online 28 August 2020
Year: 2020
Type: Science
Subject: A team led by Radu Aricescu’s group created a synthetic compound that acts like a ‘bridge’ where connections have been lost due to damage or illness, offering hope of new therapies for a range of devastating conditions, from Alzheimer’s disease to epilepsy
Keywords: Cerebellin-1, CPTX; Alzheimer’s disease; Radu Aricescu; brain; neuronal cells; neurodegeneration; synaptic; spinal cord; regenerate; ‘cut and paste’; epilepsy
Photographs:Author: Ferro, Diana
Title: Dr. Jailson Brito Querido
Reference RNA Society 22 September 2020
Year: 2020
Type: Career Structure
Subject: RNA Society Spotlight features Jailson Brito Querido, a postdoctoral researcher in Venki Ramakrishnan’s group. Jailson describes how he became interested in RNA biology, why he wanted to come to the LMB, and who his scientific hero is
Keywords: Jailson Brito Querido; Venki Ramakrishnan; RNA Society; Marie Curie; helcases; translation; elF4A; career
Photographs: Jailson Brito Querido in Lab (MRC LMB)Author: Biochemical Society
Title: Professor Kim Nasmyth awarded the 2021 Centenary Award by Biochemical Society
Reference Biochemical Society 25 March 2020
Year: 2020
Type: Alumni - Awards & Prizes
Subject: Kim, who is currently the Whitley Chair at the Department of Biochemistry, University of Oxford and a fellow of Trinity College is a former member of LMB, has made hugely valuable contributions to the life sciences. He has been awarded the Biochemistry Society Centenary Award for 2021.
Keywords: Kim Nasmyth; Biochemistry Society Centenary Award; alumni; cell biology
Photographs: Head shot of Kim NasmythAuthor: University of Cambridge News
Title: Tackling COVID-19: Dr Sarah Caddy
Reference University of Cambridge 26 June 2020
Year: 2020
Type: Alumni - Science
Subject: Sarah Caddy is interviewed about her work on COVID-19 during the pandemic and extending her work with Leo James’ group on how antibodies neutralise rotavirus and influenza to include coronaviruses
Keywords: Sarah Caddy; Alumni; COVID-19; SARS-CoV-2; coronavirus; antibody; vaccines; pets; Ebola; Leo James
Photographs: Sarah Caddy in the labAuthor: National Academy of Sciences News
Title: National Academy of Sciences Elects New Members
Reference National Academy of Sciences 27 April 2020
Year: 2020
Type: Alumni - Awards & Prizes
Subject: The National Academy of Sciences of the USA recognises distinguished and continuing achievements in original scientific research by election to membership and has recently elected 120 members and 26 international members including Anthony Hyman
Keywords: Anthony Hyman; alumni; Nation Academy of Sciences USA; Newly elected; award; Director; Max Planck Institute of Molecular Cell Biology and Genetics; member
Photographs:Author: Royal Microscopical Society
Title: Yanlan Mao is awarded the 2021 Royal Microscopical Society Medal for Life Sciences
Reference Royal Microscopical Society 6 August 2020
Year: 2020
Type: Alumni - Awards & Prizes
Subject: Yanlan Mao, who did her PhD with Matthew Freeman’s group in Cell Biology Division, has been awarded the RMS Medal for Life Sciences in recognition of her important contribution to our understanding of how cells and tissues are shaped and organised during the developmental process
Keywords: Yanlan Mao; Royal Microscopical Society Medal; alumni; award; Matthew Freeman; winner; Life Sciences
Photographs: Head Shot of Yanlan