Author: Chem@Cam
Title: Reactivating protein mutants - a new way to cure cancer?
Reference Chem@Cam, Autumn 2008, pp.8-9
Year: 2008
Type: Science
Subject: A profile of Alan Fersht and his work on proteins. His work at LMB is featured in his ‘CV’.
Keywords: Brandeis University; Sydney Brenner; cancer; chess; Francis Crick; Alan Fersht; Marilyn [Fersht]; Naomi [Fersht]; Phil [Fersht]; [Gonville and] Caius [College]; Herchel Smith Professor of Organic Chemistry; Dorothy Hodgkin; Imperial College; Bill Jenks; Tony Kirby; Aaron Klug; p53; Max Perutz; protein folding; proteins; Royal Society Wolfson chair; Walthamstow
Photographs: Fersht with his Royal Society Medal and the GN Lewis Medal from Berkley; illustration of the core domain of a mutant p53, with the molecule they designed filling a cavity induced by the mutation; Fersht with his group of scientistsAuthor: Highfield, Roger
Title: DNA surgery offers hope
Reference The Telegraph, 23 September 2008
Year: 2008
Type: Science
Subject: New research gives gene therapy the chance to fulfil its potential. Aaron Klug’s work is referenced.
Keywords: CCR5; DNA; gene therapy; Carl June; Aaron Klug; Sangamo BioSciences; Adrian Thrasher; Daniel Voytas; zinc fingers
Photographs: Hand holding a needle (blurred).Author: MRC
Title: Writers join scientists for creative conversation
Reference MRC News & Publications, 23 July 2008
Year: 2008
Type: Events/Celebrations
Subject: MRC scientists and fiction writers came together in a discussion to explore the sources of their ideas and their passion for discovery. Aaron Klug was one of the featured scientists.
Keywords: Creative Energy; Sian Ede; English PEN; Gulkenkian Foundation; Aaron Klug; MRC Clinical Trials Trust; Sheena McCormack; Ian McEwan; Ruth Padel; Royal Geographical Society
Photographs:Author: Medical Laboratory News
Title: £67m for ‘flagship’ MRC lab
Reference Medical Laboratory World, 26 June 2008
Year: 2008
Type: Funding
Subject: The research capacity of the LMB has been strengthened with £67m funding from the Department of Innovation, Universities and Skills (DIUS) for the construction of a new building.
Keywords: Leszek Borysiewicz; Cambridge Biomedical Campus; Department of Innovation, Universities and Skills (DIUS); LMB-2; University of Cambridge
Photographs:Author: MRC
Title: Leap forward in structural biology will revolutionise drug making
Reference MRC News & Publications, 25 June 2008
Year: 2008
Type: Science
Subject: A new method (developed at LMB) for determining the architecture of key drug targets that relay messages into our cells could revolutionise the way we make and test drugs.
Keywords: adrenergic receptors; drugs; G protein-coupled receptors (GPCRs); Richard Henderson; Nature (journal); Gebhard Schertler; Chris Tate
Photographs: Structure of the stress hormone receptor B1 with a beta blocker bound to itAuthor: Fersht, Alan R.
Title: From the first protein structures to our current knowledge of protein folding: delights and scepticisms
Reference Nature Review Molecular Cell Biology 9 (8), August 2008, pp.650-654
Year: 2008
Type: Science
Subject: A look back to the publication of the first structures of proteins at atomic resolution (in 1958) and the impact this had on the field of protein folding. The LMB features in this history.
Keywords: Christian Anfinsen; Robert Baldwin; Sydney Brenner; Cyrus Chothia; Tom Creighton; Francis Crick; S. Walter Englander; Human Genome Project; [Martin] Karplus; John Kendrew; Aaron Klug; Herman Lehmann; Michael Levitt; Cyrus Levinthal; [Kaj Ulrik] Linderstrøm-Lang; Cesar Milstein; myoglobin; NMR spectroscopy; Max Perutz; David Phillips; protein engineering; protein folding; Protein Structure Initiative; Oleg Ptitsyn; recombinant DNA technology; Fred Sanger; [David] Weaver; X-ray crystallography
Photographs: Three-dimensional structure of myoglobin (Kendrew et al); Max Perutz and John Kendrew respectively holding their models of haemoglobin and myoglobin; the pathway of folding of the Engrailed homeodomain of Drosophila melangasterAuthor: Highfield, Roger
Title: Laboratory of Molecular Biology, Cambridge to be rebuilt to look like a cell
Reference The Telegraph, 25 July 2008
Year: 2008
Type: Architecture & Buildings
Subject: The LMB is to undergo a £200 million refurbishment so it will end up looking like the innards of a cell
Keywords: Leszek Borysiewicz; Jason Chin; chromosomes; John Denham (Secretary of State for Innovation, Universities and Skills); LMB-2; monoclonal antibodies; Hugh Pelham; Max Perutz; Venki Ramakrishnan; Fred Sanger
Photographs:Author: Medical News Today
Title: New World Class Laboratory To Boost Medical Research - £200 Million Rebuild Of The Internationally Renowned Laboratory Of Molecular Biology
Reference Medical News Today, 25 June 2008
Year: 2008
Type: Funding
Subject: A £200 million rebuild of the LMB was given the go-ahead by John Denham, Secretary of State for Innovation, Universities and Skills.
Keywords: asthma; Leszek Borysiewicz; Cambridge University; John Denham; Department of Innovation, Universities and Skills (DIUS); Herceptin; Large Facilities Capital Fund; LMB-2; monoclonal antibodies; Nobel Prize
Photographs:Author: Press Association
Title: Cancer-causing viruses exploit genetic achilles heel, finds study
Reference The Guardian, 25 April 2010
Year: 2010
Type: Science
Subject: Some viruses learned to protect themselves by exploiting a natural "brake" on the immune system, research has shown. The study was carried out by Cancer Research UK in collaboration with LMB. Nature Cell Biology (Martin Fabani co-authored) paper available here: http://www.nature.com/ncb/journal/v12/n5/pdf/ncb2054.pdf
Keywords: cancer; Cancer Research UK; Kaposi’s sarcoma; Dimitris Lagos; microRNAs; Nature Cell Biology; University College London; Lesley Walker
Photographs: DNA illustrationAuthor: Business Wire
Title: Bicycle Therapeutics Signs License Agreement with EPFL and Adds SR One and SVLS to Seed Syndicate
Reference Business Wire, 29 April 2010
Year: 2010
Type: Biotechnology Companies
Subject: Bicycle Therapeutics (an LMB spin-out company) establishes a relationship with EPFL and receives further funding from two top ranked investors to complete its seed phase investment.
Keywords: Atlas Venture; Babraham Research Campus; Bicycle Therapeutics; Kate Bingham; CAT; Gabriel Clerc; Domantis; Ecole Polytechnique Federale de Lausanne (EPFL); GlaxoSmithKline; Debbie Harland; Christian Heinis; Novartis Venture Fund; SR One; SV Life Sciences; John Tite; Gregory Winter
Photographs:Author: Business Weekly
Title: Work on £197 million lab of the future to start in Cambridge
Reference Business Weekly, 24 June 2008
Year: 2008
Type: Architecture & Buildings
Subject: The MRC has received £67 million government funding towards a new £197m building for the LMB.
Keywords: Addenbrooke’s Hospital; Avastin; Leszek Borysiewicz; Cambridge Biomedical Campus; Cancer Research UK; Clinical School; DNA sequencing; Herceptin; Human Genome Project; Georges Kohler; LMB-2; Cesar Milstein; monoclonal antibodies; Hugh Pelham; Max Perutz; Venki Ramakrishnan; Frederick Sanger; University of Cambridge; Wellcome Trust
Photographs: Computer-generated image of the new LMB.Author: Lipsett, Anthea
Title: World famous Cambridge lab to get £67m
Reference The Guardian, 24 June 2008
Year: 2008
Type: Funding
Subject: LMB to receive £67m in government funding for rebuilding
Keywords: Leszek Borysiewicz; John Denham; Department of Innovation, Universities and Skills; LMB-2
Photographs:Author: MRC
Title: Work on laboratory of the future to begin in Cambridge
Reference MRC News & Publications, 24 June 2008
Year: 2008
Type: Architecture & Buildings
Subject: The MRC has received £67 million towards a new building for the LMB from the Department for Innovation, Universities and Skills.
Keywords: Addenbrooke’s Hospital; Leszek Borysiewicz; Cambridge Biomedical Campus; Cambridge City Council; Cancer Research UK; John Denham; Department for Innovation, Universities and Skills; Human Genome Project; Georges Kohler; Large Facilities Capital Fund (LFCF); Cesar Milstein; Hugh Pelham; Max Perutz; Frederick Sanger; University of Cambridge; Wellcome Trust; Gregory Winter
Photographs:Author: Department for Innovation, Universities and Skills
Title: New World Class Laboratory To Boost Medical Research
Reference Department for Innovation, Universities and Skills, [June 2008]
Year: 2008
Type: Funding
Subject: A £200 million rebuild of the LMB was given the go-ahead by John Denham, Secretary of State for Innovation, Universities and Skills.
Keywords: Leszek Borysiewicz; Cambridge University; John Denham; Department of Innovation, Universities and Skills (DIUS); Large Facilities Capital Fund; LMB-2; Nobel Prize
Photographs:Author: Brabden, Donald (and others)
Title: Scientists need freedom to create Planck Club for this era
Reference Financial Times, 2 June 2008
Year: 2008
Type: Politics
Subject: Letter to the Financial Times undersigned by many scientists (including LMB’s Peter Lawrence) arguing that scientists need more freedom.
Keywords: John F. Allen; [Oswald] Avery; Donald Braben; [Francis] Crick; Adam Curtis; John Dainton; [Albert] Einstein; Nigel Franks; Dudley Herschbach; Pat Heslop-Harrison; Steve Howdle; Herbert Huppert; [John] Kendrew; H. Jeff Kimble; Harry Kroto; Peter Lawrence; Philip Moriarty; Martyn Poliakoff; David Price; Nobel Prize; [Max] Perutz; [Max] Planck; Planck Club; Douglas Randall; David Ray; Peter Rich; Ken Seddon; Robert Solow; Gene Stanley; Harry Swinney; [Charles Hard] Townes; Robin Tucker; Nick Tyler; Claudio Vita-Finzi; [James] Watson
Photographs:Author: BBC News
Title: Body clock reset clue discovered
Reference BBC News, 15 May 2008
Year: 2008
Type: Science
Subject: Studies in mice have shown cAMP - a common signalling molecule - is involved in keeping the body clock “rhythms” going. The LMB was involved in the studies.
Keywords: body clock; circadian rhythms; cAMP; Michael Hastings; Norwich University Hospital; Science; sleep; Neil Stanley
Photographs: Woman in bedAuthor: MRC
Title: New dimension discovered in body clock rhythm
Reference MRC News & Publications, 16 May 2008
Year: 2008
Type: Science
Subject: Research on what makes the body clock tick has led LMB’s Michael Hastings to discover a new and unanticipated cog in the human body clock. A patent for the compound involved has been filed by MRC Technology.
Keywords: body clock; c-AMP; circadian rhythms; Michael Hastings; MRC Technology; Science; suprachiasmatic nuclei (SCN)
Photographs:Author: Morgan, John
Title: Body clock work could end jet lag
Reference Cambridge News, 16 May 2008, p.10
Year: 2008
Type: Science
Subject: Work at LMB could lead to therapies for people whose sleep is disrupted by long-distance travel, shift work or old age.
Keywords: body clock; c-AMP; circadian rhythms; Michael Hastings; jet-lag; Elizabeth Maywood; John O’Neill
Photographs: Michael Hastings, in the labAuthor: Cambridge News
Title: Doc becomes a Fellow
Reference Cambridge News, 7 May 2008, p.7
Year: 2008
Type: Awards & Prizes
Subject: Mick Hastings has been awarded the Fellowship of the Academy of Medical Sciences
Keywords: circadian neurobiology; Fellowship of the Academy of Medical Sciences; Michael Hastings
Photographs:Author: McKie, Robin
Title: Biologists join the race to create synthetic life
Reference The Observer, 20 April 2008
Year: 2008
Type: Science
Subject: Researchers will gather in London this week to outline plans to promote synthetic biology. LMB’s Philipp Holliger is quoted in the article.
Keywords: Engineering Life; Imperial College London; Richard Kitney; Manchester Interdisciplinary Biocentre; John McCarthy; synthetic biology; Craig Venter
Photographs:Author: Highfield, Roger
Title: Gene surgery trials offer hope for diabetics and Aids sufferers
Reference Daily Telegraph, 18 March 2008, p.15
Year: 2008
Type: Science
Subject: A pioneering form of genetic surgery is being tested by Aaron Klug, and could lead to new treatments for Aids, diabetes and chronic pain.
Keywords: gene therapy; Aaron Klug; Nobel Prize; Proceedings of the National Academy of Sciences; zinc fingers
Photographs:Author: BBC News
Title: Gene targeting raises cure hopes
Reference BBC News, 18 March 2008
Year: 2008
Type: Science
Subject: A more efficient way to shut down rogue genes raises hopes of new therapies for conditions like diabetes and HIV. Aaron Klug is quoted throughout the article.
Keywords: Aids; Vincent Cunliffe; gene targeting; Aaron Klug; Proceedings of the National Academy of Sciences; Sangamo BioSciences; zinc fingers
Photographs: DNA illustrationAuthor: Ball, Philip
Title: Complexity crystallised
Reference Chemistry World 5 (3), March 2008, pp.50-56
Year: 2008
Type: Historical - LMB History
Subject: An overview of the history of protein x-ray crystallography, and a look to current issues in the field. The work of John Kendrew and Max Perutz is featured.
Keywords: David Baker; J Desmond Bernal; William Bragg; Bruker AXS; Jamie Cate; Cavendish laboratory; Johann Diesenhofer; haemoglobin; Dorothy Hodgkin; Robert Huber; John Kendrew; Martmut Michel; Molecular Dimensions; Lord Mountbatten; myoglobin; Oxford Cryosystems; Oxford Diffraction; Max Perutz; photosynthetic reaction centre (PRC); Protein Data Bank; protein folding; Rigaku; Structural Genomics Consortium; Max von Laue; x-ray crystallography; Ahmed Zewail
Photographs: Model of the crystal structure of myoglobin; John Kendrew and Max Perutz; a protein crystal; the predicated structure of a protein overlaid with its experimentally determined structure; a micrograph and diffraction pattern taken by ultrafast electron microscopy and diffractionAuthor: Paterlini, Marta
Title: Exhibition: A protein ghost etched in glass
Reference Nature 452, 13 March 2008, p.155
Year: 2008
Type: Exhibitions
Subject: Drawing from Max Perutz’s idea to encourage photographers and designers to be part of the scientific team, the Design4Science exhibition in Stockholm features a sculpture by an artist inspired by ATP synthase.
Keywords: art; ATP synthase; Design4Science; Irving Geis; Nobel Museum; Max Perutz; protein crystallography; Colin Rennie
Photographs: Colin Rennie’s sculptureAuthor: Coghlan, Andy
Title: Antibodies get bigger deal from bacteria
Reference New Scientist, 6 August 1994, p.20
Year: 1994
Type: Science
Subject: Scientists from LMB have announced details of a synthetic system that can generate antibodies that bind unusually strongly to target molecules, making them more effective against disease.
Keywords: antibodies; antigen; bacteriophage; Andrew Griffiths; Greg Winter
Photographs: A Y-shaped antibody binds to an antigen (computer-generated image)