Author: McKie, Robin
Title: Biologists join the race to create synthetic life
Reference The Observer, 20 April 2008
Year: 2008
Type: Science
Subject: Researchers will gather in London this week to outline plans to promote synthetic biology. LMB’s Philipp Holliger is quoted in the article.
Keywords: Engineering Life; Imperial College London; Richard Kitney; Manchester Interdisciplinary Biocentre; John McCarthy; synthetic biology; Craig Venter
Photographs:Author: Highfield, Roger
Title: Gene surgery trials offer hope for diabetics and Aids sufferers
Reference Daily Telegraph, 18 March 2008, p.15
Year: 2008
Type: Science
Subject: A pioneering form of genetic surgery is being tested by Aaron Klug, and could lead to new treatments for Aids, diabetes and chronic pain.
Keywords: gene therapy; Aaron Klug; Nobel Prize; Proceedings of the National Academy of Sciences; zinc fingers
Photographs:Author: BBC News
Title: Gene targeting raises cure hopes
Reference BBC News, 18 March 2008
Year: 2008
Type: Science
Subject: A more efficient way to shut down rogue genes raises hopes of new therapies for conditions like diabetes and HIV. Aaron Klug is quoted throughout the article.
Keywords: Aids; Vincent Cunliffe; gene targeting; Aaron Klug; Proceedings of the National Academy of Sciences; Sangamo BioSciences; zinc fingers
Photographs: DNA illustrationAuthor: Ball, Philip
Title: Complexity crystallised
Reference Chemistry World 5 (3), March 2008, pp.50-56
Year: 2008
Type: Historical - LMB History
Subject: An overview of the history of protein x-ray crystallography, and a look to current issues in the field. The work of John Kendrew and Max Perutz is featured.
Keywords: David Baker; J Desmond Bernal; William Bragg; Bruker AXS; Jamie Cate; Cavendish laboratory; Johann Diesenhofer; haemoglobin; Dorothy Hodgkin; Robert Huber; John Kendrew; Martmut Michel; Molecular Dimensions; Lord Mountbatten; myoglobin; Oxford Cryosystems; Oxford Diffraction; Max Perutz; photosynthetic reaction centre (PRC); Protein Data Bank; protein folding; Rigaku; Structural Genomics Consortium; Max von Laue; x-ray crystallography; Ahmed Zewail
Photographs: Model of the crystal structure of myoglobin; John Kendrew and Max Perutz; a protein crystal; the predicated structure of a protein overlaid with its experimentally determined structure; a micrograph and diffraction pattern taken by ultrafast electron microscopy and diffractionAuthor: Paterlini, Marta
Title: Exhibition: A protein ghost etched in glass
Reference Nature 452, 13 March 2008, p.155
Year: 2008
Type: Exhibitions
Subject: Drawing from Max Perutz’s idea to encourage photographers and designers to be part of the scientific team, the Design4Science exhibition in Stockholm features a sculpture by an artist inspired by ATP synthase.
Keywords: art; ATP synthase; Design4Science; Irving Geis; Nobel Museum; Max Perutz; protein crystallography; Colin Rennie
Photographs: Colin Rennie’s sculptureAuthor: Coghlan, Andy
Title: Antibodies get bigger deal from bacteria
Reference New Scientist, 6 August 1994, p.20
Year: 1994
Type: Science
Subject: Scientists from LMB have announced details of a synthetic system that can generate antibodies that bind unusually strongly to target molecules, making them more effective against disease.
Keywords: antibodies; antigen; bacteriophage; Andrew Griffiths; Greg Winter
Photographs: A Y-shaped antibody binds to an antigen (computer-generated image)Author: MRC
Title: Award winning images of science
Reference MRC News & Publications, 12 March 2008
Year: 2008
Type: Awards & Prizes
Subject: Three images captured by MRC scientists (including one by LMB’s Venki Ramakrishnan) have won Wellcome Trust Image Awards 2008
Keywords: mouse embryo; MRC Human Genetics Unit, Edinburgh; MRC National Institute for Medical Research, London; Venki Ramakrishnan; ribosome; RNA; seminiferous tubule; James Sharpe; Kate Sullivan; Wellcome Collection; Wellcome Trust Image Awards
Photographs: mouse embryo (computer-generated image); molecular model of a ribosome (computer-generated image); seminiferous tubule (computer-generated image)Author: Gowers, W. Timothy
Title: Bridging the Cultural Divide
Reference Science 320, 16 May 2008, pp.875-6
Year: 2008
Type: Exhibitions
Subject: Review of the exhibition “Beyond Measure” at Kettle’s Yard [which included Aaron Klug’s original virus models.]
Keywords: art; Beyond Measure; Conversations Across Art and Science; exhibition; glass Klein bottles; Ernst Gombrich; Inversions; Kettle’s Yard; Quad Start Double Bounded Random Walk; sculpture; Keith Tyson;
Photographs: Glass Klein bottles, Alan Bennett (1995)Author: Campbell-Johnston, Rachel
Title: Maths at their fingertips
Reference The Times, 9 April 2008, p.12
Year: 2008
Type: Exhibitions
Subject: Review of the exhibition “Beyond Measure” at Kettle’s Yard [which included Aaron Klug’s original virus models.]
Keywords: Tariq Ahmed; art; Arts Catalyst; Christoph Bergemann; Beyond Measure; Dana Institute; Leonardo da Vinci; Fermi; Buckminster Fuller; geometry; Eve Hild; Kettle’s Yard; Aaron Klug; Leonardo da Vinci; mathematics; Allan McRobie; Claude Monet; David Nash; John Pickering; James Turrell; Johannes Vermeer; Wellcome Foundation; Father Magnus Wenninger
Photographs: Eve Hild’s ceramic Broad Complex; Model F by John Pickering; Father Magnus Wenninger’s 3D Models of 4D Ploytopes - Set No 7; Fermi surfaces, mapped by Christoph BergemannAuthor: Cambridge News
Title: Artistic twist in the world of geometry
Reference Cambridge News, 8 April 2008, p.18
Year: 2008
Type: Exhibitions
Subject: A look at the exhibition “Beyond Measure” at Kettle’s Yard, which includes Aaron Klug’s original virus models.
Keywords: art; Alan Bennett; Christoph Bergemann; Beyond Measure; Richard Deacon; Tom Dixon; Felix Gonzales-Torres; Kettle’s Yard; Klein bottles; Robert Morris; Sarah Morris; David Nash; Roger Penrose; Amanda Rigler; Daina Taimina; virus structure models; Father Magnus Wenninger; Christopher Wren
Photographs: Model of a hyperbolic area made from crocheted wool by Daina Taimina; painting by Sarah Morris; Barry Phipps with a molecular exhibit from Aaron Klug; virus model structure by Aaron Klug; Amanda Rigler with one of Father Magnus Wenninger’s models; Alan Bennett’s Klein bottles; a pylon chair by Tom Dixon; a 3D paper model by Father Magnus Wenninger; an image of Fermi surfaces by Christoph BergemannAuthor: MRC
Title: More efficient gene targeting improves prospects for gene therapy
Reference MRC News & Publications, 18 March 2007
Year: 2007
Type: Science
Subject: LMB’s Aaron Klug and a team from an American company, Sangamo BioSciences, have announced a new way to target genes that may revolutionise medical research and pave the way for new treatments.
Keywords: AIDS; gene targeting; Aaron Klug; PNAS; Sangamo BioSciences; zinc-finger nucleases
Photographs:Author: Ezzell, Carol
Title: The flatworm’s turn
Reference Nature 339, 29 June 1989, p.648
Year: 1989
Type: Science
Subject: The nematode may be the first higher organism to have its genes ordered onto a physical map. Researchers at LMB are helping to break down the genome.
Keywords: [George] Bush; contigs; flatworm; genome; Michael Kemp; model organisms; nematode; NIH Office of Human Genome Activities; US National Institute of Health (NIH); Robert Waterson; James Watson; Norton Zinder
Photographs:Author: Dickson, David
Title: Watson Floats a Plan to Carve Up the Genome
Reference Science 244 (4904), 5 May 1989, pp.521-2
Year: 1989
Type: Science
Subject: The head of the US genome project suggests giving individual countries responsibility for specific chromosomes. Sydney Brenner is also quoted in the article
Keywords: Michael Andrews; Sydney Brenner; Ralph Christoffersen; chromosomes; Pete V. Domenici; genome; Walter Gilbert; Human Genome Mapping Organization (HUGO); Victor McKusick; MRC Molecular Genetics Unit; Soviet Academy of Sciences; US National Institute of Health (NIH); James Watson
Photographs: James WatsonAuthor: Friedberg, Errol C.
Title: An interview with... Aaron Klug
Reference Nature Reviews Molecular Cell Biology 9, February 2008, pp.96-7
Year: 2008
Type: Biographical
Subject: Aaron Klug is interviewed about subjects including current science research, technology, and his career as a scientist.
Keywords: Seymour Benzer; J. D. Bernal; Lawrence Bragg; Sydney Brenner; coins; Francis Crick; Rosalind Franklin; Google; humane genome project; Imperial College; R. W. James; Medline; peer review; Sangamo Biosciences; University of Cape Town; University of Witwatersrand, Johannesburg
Photographs: Aaron KlugAuthor: Gillespie, Fulton
Title: Major accolade for ‘genius’ labs
Reference Cambridge Evening News, [1990]
Year: [1990]
Type: Historical - MRC
Subject: The LMB is to get a major boost under Government plans to expand the MRC’s regional centres.
Keywords: Advisory Board for the Research Councils (ABRC); Sydney Brenner; Department of Education; Aaron Klug; Laboratory of Molecular Genetics; National Research Council; Nobel Prize; Max Perutz
Photographs:Author: Bendiner, Elmer
Title: The MRC Today: British Science at the Crossroads
Reference Hospital Practice, 15 July 1987, pp.35-64
Year: 1987
Type: Historical - MRC
Subject: Profile of the various MRC units, including the LMB.
Keywords: Christopher Addison; James Edwin Barnard; John Desmond Bernal; William Lawrence Bragg; Sydney Brenner; British Broadcasting Corporation (BBC); A. S. V. Burgen; F. Macfarlane Burnet; Cambridge University; Cavendish Laboratory; Celltech; Cellular Immunology Research Unit; Centre for Collaborative Research; Winston Churchill; Francis Crick; George Curzon; Department of Health; The Doctor’s Dilemma [play]; Faraday Society; Alexander Fleming; Klaus Fuchs; Rosalind Franklin; David Lloyd George; glaciers; James Godwans; Charles H. Harlington; Adolf Hitler; Gowland Hopkins; Hugh Huxley; Imperial Development Board; John Kendrew; Aaron Klug; Robert Koch; Lev Landau; magic bullets; Hermann Mark; Peter B. Medawar; Medical Research Committee; Mill Hill; Cesar Milstein; Ministry of Health; Molecular [Haematology] Unit; monoclonal antibodies; Robert Morant; National Institute for Medical Research; National Institutes of Health [US]; National Insurance Act; Nature (journal); Nobel Prize; patents; pay; Linus Pauling; Max Perutz; Project Habakkuk; Dai Rees; Rockerfeller Foundation; Royal Commission Appointed to Inquire into the Relations of Human and Animal Tuberculosis; Fred Sanger; George Bernard Shaw; St Mary’s Hospital; John Steinbeck; Unilever; James D Watson; David Weatherall; Beatrice Webb; Maurice Wilkins; Women’s Royal Naval Service; Almroth Wright
Photographs: James Gowans; Aaron Klug; Cesar Milstein; Maurice Wilkins, Max Perutz, Francis Crick, John Steinbeck, James D. Watson and John Kendrew at the 1962 Nobel prize ceremony.Author: Roberts, Leslie
Title: Genome Mapping Goal Now in Reach
Reference Science 244 (4903), 28 April 1989, pp.424-425
Year: 1989
Type: Science
Subject: New mapping strategies may allow scientists to map the human genome within 5 years.
Keywords: Alzheimer’s; Dorra Cherif; Cold Spring Harbor; contig; David Cox; DNA; Steve Goss; Henry Harris; human genome project; Eric Lander; Peter Lichter; mapping; Richard Myers; National Institutes of Health (NIH); Maynard Olson; saturation hybridization; situ hybridization; Evani Viegas-Pequigot; David Ward; James Watson
Photographs: David WardAuthor: Picknett, Tessa
Title: Journal of Molecular Biology: A Publisher’s Perspective
Reference Journal of Molecular Biology 293 (2), 22 October 1999, pp.165-71
Year: 1999
Type: Miscellaneous
Subject: History of the Journal of Molecular Biology, whose editorial staff many former LMB members belonged to.
Keywords: Academic Press; Phyllis Ansel; G. Attardi; R. L. Baldwin; Leslie Barnett; Seymour Benzer; Sydney Brenner; S. Bernhard; Mark Bretscher; John Cairns; Melvin Calvin; Cambridge; C. R. Canton; Cavendish Laboratory; Cell [journal]; Pierre Chambon; Georges N. Cohen; Francis Crick; James F. Danielli; James E. Darnell; J. Davies; D. J. DeRosier; Paul Doty; A. Engstrom; European Molecular Biology Organisation (EMBO); G. Felsenfeld; G. A. Gilbert; Walter Gilbert; Alfred D. Hershey; Geoff Hudson; Graeme Hunter; J. Hurwitz; Hugh E. Huxley; Andrew F. Huxley; International Digital Electronic Access Library (IDEAL); Francois Jacob; Journal of Molecular Biology (JMB); A. D. Kaiser; Jonathan Karn; John Kendrew; Aaron Klug; Arthur Kornberg; C. Levinthal; Tony Lowe; S. Lowey; Salvador E. Luria; Vittorio Luzatti; Brian W. Matthews; D. Mazia; Peter B. Medawar; Medline; Matthew Meselson; Sherwin B. Nuland; Leslie E. Orgel; George E. Palade; Max Perutz; Peterhouse College; David C. Philips; R. D. Preston; G. M. Ramachandran; Wendy ap Rees; Alexander Rich; C. C. Richardson; Robert Schleif; Gerhard Schramm; Science [journal]Adrian Simpson; Robert L. Sinsheimer; F. S. Sjostrand; Ed Southern; Nat Sternberg; Lubert Stryer; C. Thomas; Alfred Tissieres; Vital Forces; G. von Ehrenstein; Peter von Hippel; P. M. B. Walker; I. Watanabe; James Watson; Klaus Weber; S. M. Weissman; Maurice H. F. Wilkins; R. C. Williams; Peter Wright; Jeffries Wyman
Photographs: Original promotional flyer for the nascent Journal of Molecular Biology; front cover of the first issue of JMB; contents pages for the first volume of JMB; new front cover for JMB, 1970; example of the third cover design, used prior to 1994; latest cover design for JMB.Author: Glynn, Jenifer
Title: Rosalind Franklin: 50 years on
Reference Notes & Records of the Royal Society 62 (2), June 2008, pp.253-55
Year: 2008
Type: Biographical
Subject: Jenifer Glynn remembers her sister, Rosalind Franklin. Past and present LMB members are mentioned, as well as the lab’s tobacco mosaic virus model.
Keywords: Desmond Bernal; Francis Crick; DNA; double helix; Rosalind Franklin; Raymond Gosling; Kings College; Aaron Klug; Brenda Maddox; Newnham [College]; Nobel Prize; Robert Olby; Anne Sayre; St Paul’s; tobacco mosaic virus model; James Watson; Maurice Wilkins
Photographs:Author: Huxley, Hugh E.
Title: Francis Crick: Hunter of Life’s Secrets: an intellectual biography by Robert Olby
Reference FASEB Journal 24 (4), April 2010, pp.976-79
Year: 2010
Type: Book Review
Subject: Hugh Huxley reviews Robert Olby’s biography of Francis Crick.
Keywords: Edward Andrade; Lawrence Bragg; brain; [Sydney] Brenner; canteen; Cavendish; Francis Crick; Odile Crick; Crick Week; DNA; Jacob [Francis]; [Rosalind] Franklin; [Raymond] Gosling; A. V. Hill; John Kendrew; King’s College; Georg Kreisel; Harrie Massey; Arthur Mee; Edward Mellanby; [Jacques] Monod; Royal Navy; Nobel Prize; Linus [Pauling]; Nobel Prize; Robert Olby; [Arthur] Pardee; Max Perutz; Salk Institute; [Alex] Stokes; Strangeways; University College London; [James] Watson; [Maurice] Wilkins; [Herbert] Wilson; X-ray
Photographs: Cover image of Olby’s bookAuthor: Oregon Health & Science University
Title: NEW ENDOWED CHAIR HONORS PIONEERING WOMAN WHO ‘BROUGHT THE FIREWORKS’ TO MOLECULAR BIOLOGY
Reference Oregon Health & Science University, 30 April 2010
Year: 2010
Type: Awards & Prizes
Subject: Hildegard Lamfrom, a former member of LMB, is posthumously honoured with a n endowed chair in her name (the Hildegard Lamfrom Endowed Chair in Basic Science at the OHSU Knight Cancer Institute).
Keywords: Sydney Brenner; Tim Boyle; Mary Boyle; California Institute of Technology; cancer; Columbia Sportswear; Francis Crick; Brian Druker; fireworks; Richard Feynman; Gleevec; Knight Center for Cell Signaling; Eva [Lamfrom]; Hildegard Lamfrom; Lasker Award; Gail Mandel; OHSU Foundation; Linus Pauling; Red Dwarf [TV series]; Reed College; James Watson
Photographs: Hildegard Lamfrom, Mark Bretscher and James WatsonAuthor: Cosgrove, Andrew
Title: Transcriptional control in flies
Reference BioMed Central Blog, 7 May 2010
Year: 2010
Type: Science
Subject: “In a paper recently published in Genome Biology, Boris Adryan (Cambridge University) and Sarah Teichmann (LMB) have presented evidence that calls in to question currently-held beliefs about how transcription factors (TFs) coordinate gene expression during development to specify the fates of the different tissues in the body.”
Keywords: Boris Adryan; Drosophila melanogaster; Genome Biology; Uwe Ohler; Sarah Teichmann; transcriptional factors (TFs)
Photographs:Author: LCN
Title: How do cells crawl?
Reference LCN Research Highlights, 2010
Year: 2010
Type: Science
Subject: Researchers at the London Centre for Nanotechnology and in Cambridge have developed a physical model that explains how cells move. The LMB’s Murray Stewart is one of the authors of the PNAS paper.
Keywords: amoeboid cell motility; Arp2/3; Tom Duke; lamellipod; polymerisation; Proceedings of the National Academy of Sciences; Christian Schreiber; Murray Stewart
Photographs: “Simulation of the dynamic mesh of branched actin filaments within a lamellipod”Author: Nanowerk
Title: UK-Europe collaborations harness biology for engineering
Reference Nanowerk News, 19 May 2010
Year: 2010
Type: Funding
Subject: Four new projects will develop biological methods that offer a new approach to antibiotic production, power generation for extremely small mechanical components, new classes of medicines and innovative techniques to study cell biology. One of the projects is led by Philip Holliger at the LMB.
Keywords: aptamer; Janet Allen; Richard Barry; Biotechnology and Biological Sciences Research Council (BBSRC); Engineering and Physical Sciences Research Council (EPSRC); European Collaborative Research Scheme (EUROCORES); European Science Foundation; EuroSYNBIO Programme; Philip Holliger; Minister for Universities and Science; NANOCELL; Sciencewise ERC; David Sherratt; SINTEF; synthetic biology; Nicolas Szita; Lesley Thompson; US National Science Foundation; David Willetts
Photographs:Author: ERBI
Title: Heptares Therapeutics extends multi-fte chemistry collaboration with oxygen healthcare (o2h)
Reference ERBI, 20 May 2010
Year: 2010
Type: Funding
Subject: Executives from Heptares Therapeutics and O2h announce an extension of the agreement under which O2h provides multi-FTE -synthetic chemistry services to support discovery programmes at Heptares. Heptares partly arose out of work conducted by scientists at LMB.
Keywords: ADME; Ahmedabad, India; Miles Congreve; GPCRs; Heptares Therapeutics; National Institute for Medical Research; O2h; Sunil Shah; StaR technology
Photographs: