Author: Roland, Denise
Title: British biotech Heptares snapped up by Japan’s Sosei in $400m deal
Reference The Telegraph 25 February 2015
Year: 2015
Type: Biotechnology
Subject: LMB spin-out company Heptares has been acquired by Japanese pharmaceutical company Soseito.
Keywords: Heptares; Alzheimer’s; biotech; Sosei; Richard Henderson; Christopher Tate; G protein-coupled receptors (GPCRs)
Photographs:Author: Nagai, Kiyoshi
Title: In the beginning was the U1A protein: a personal reflection
Reference RNA 17 March 2015
Year: 2015
Type: History - Reminiscences
Subject: Kiyoshi Nagai looks back on his research on the spliceosome, RNA-protein interactions and the RNA recognition motif, U1A protein, for RNA journal.
Keywords: Tom Steitz; Kiyoshi Nagai; Chris Oubridge; Jade Li; Joan Steitz; Adelaine Leung; U1 snRNP; Andy Newman; Kelly Nguyen; Wojtek Galej; Yasushi Kondo; Marike van Roon; ‘hairpin’; RRM; ribosome; Christian Kambach; Stephan Walke; Robert Young
Photographs:Author: Extance, Andy
Title: Reaction map suggests meteorite chemistry route to life
Reference Chemistry World 17 March 2015
Year: 2015
Type: Science
Subject: LMB scientists have found a reaction network that they believe shows that ‘pretty much everyone’ working on life’s molecular origins is wrong – but also ‘right, in a sense’.
Keywords: John Sutherland; ribonucleotides; hydrogen cyanide; Dougal Ritson; ‘extremely elegant’; meteorites; glycerol
Photographs:Author: Webb, Jonathan
Title: Biologist Venki Ramakrishnan to lead Royal Society
Reference BBC News 18 March 2015
Year: 2015
Type: Awards & Prizes
Subject: Venki Ramakrishnan is announced as the next president of the Royal Society.
Keywords: Venki Ramakrishnan; Royal Society; Paul Nurse; Colin Blakemore; president
Photographs: Venki RamakrishnanAuthor: Business Wire
Title: FORMA Therapeutics and Cancer Research Technology Form Two Virtual Companies to Advance Deubiquitination Assets
Reference Business Wire 23 March 2015
Year: 2015
Type: Biotechnology
Subject: FORMA Therapeutics and Cancer Research Technology, Ltd (CRT) have announced the formation of two new virtual Asset Discovery and Development Companies (ADDCos) to represent the collective efforts of the consortium in the field of deubiquitinating enzymes (DUBs).
Keywords: FORMA Therapeutics and Cancer Research Technology Ltd. (CRT); virtual; Asset Discovery and Development Companies (ADDCos); deubiquitination enzymes (DUBs); Cancer Research UK; Steven Tregay; drug discovery; network; David Komander
Photographs:Author: Wellcome Trust
Title: Image of the Week: Structure of the dynactin complex
Reference Wellcome Trust Blog 27 March 2015
Year: 2015
Type: Science
Subject: The structure of the dynactin complex, solved by Andrew Carter’s group at the LMB, is the cover story on this week’s Science and is the Wellcome Trust’s Image of the week.
Keywords: Wellcome Trust; dynein; dynactin; neurodegenerative diseases; motor neuron diseases; dementias; Parkinson’s disease; Andrew Carter; cryo-electron microscope; Bicaudal-D2; microtubule; image of the week
Photographs: Image showing a model of a tiny protein machine that moves things around within our cells. (Janet Iwasa, University of Utah)Author: Borman, Stu
Title: First Pictures of the Mitoribosome Taken
Reference C&EN 3 April 2015
Year: 2015
Type: Science
Subject: Researchers, including a team from the LMB, have obtained structures of complete ribosomes from mammalian mitochondria at near-atomic resolution for the first time.
Keywords: ribosome; mitochondria; mRNA; mammalian; mitroribosomes; Venki Ramakrishnan; eukaryotic; cryo-electron microscopy; mutations; atomic resolution; cytoplasm
Photographs: Cryo-electron microscopy structure of the mitoribosomeAuthor: Isle of Man Today
Title: Body clock expert talks to students
Reference Isle of Man Today 1 April 2015
Year: 2015
Type: Miscellaneous
Subject: Michael Hastings delivers sixth form lecture at King William’s College, Isle of Man, on his research into circadian rhythms and biological clocks.
Keywords: Michael Hastings; Isle of Man; King William’s College; Ramsey Grammar School; biorhythms; body clock; circadian rhythms
Photographs: Michael Hastings with two of the studentsAuthor: Hogenboom, Melissa
Title: Crystal beauty: Illuminating the structure of matter
Reference BBC News 10 November 2014
Year: 2014
Type: Exhibitions
Subject: The LMB has played a pivotal role in the development of X-ray crystallography and the inspirational work of crystallographic scientists from round the UK is showcased in an upcoming exhibition at the Royal Albert Hall
Keywords: “illuminating Atoms”; crystallography; Royal Albert Hall; Max Alexander; Francis Crick; Jim Watson; beach; sand David Keen; Max Perutz; exhibition
Photographs: Images from the exhibitionAuthor: Biochemical Society
Title: The Colworth Medal, Member Reception and AGM
Reference Biochemical Society 1 December 2014
Year: 2014
Type: Awards & Prizes
Subject: Madan, from the LMB’s Structural Studies Division, presents his award lecture and receives the prestigious 2014 Colworth Medal at the Biochemical Society’s AGM
Keywords: Madan Babu; Colworth Medal; lecture; Charles Darwin House; celebration
Photographs:Author: Coghlan, Andy
Title: Synthetic enzymes hint at life without DNA or RNA
Reference New Scientist 1 December 2014
Year: 2014
Type: Science
Subject: Enzymes that don’t exist in nature have been made from genetic material that doesn’t exist in nature either, called XNA, or xeno nucleic acid
Keywords: Philipp Holliger; XNA; xeno nucleic acid; RNA; enzyme; life on Earth; viruses; cancer; prehistoric; synthetic biology
Photographs:Author: Connor, Steve
Title: Major synthetic life breakthrough as scientists make the first artificial enzymes
Reference The Independent 1 December 2014
Year: 2014
Type: Science
Subject: For the first time ever, researchers have made synthetic enzymes – the vital ingredients needed for life – from artificial genetic material that does not exist outside the laboratory.
Keywords: synthetic biology; Phil Holliger; life on Earth; XNA; RNA; Alex Taylor; Patrick Maxwell; enzymes; cancer; viruses; “XNAzymes”; oncogene
Photographs:Author: Wong, Sam
Title: Scientists find first evidence of ‘local’ clock in the brain
Reference Imperial College London 13 November 2014
Year: 2014
Type: Science
Subject: Research by groups at Imperial College London and Michael Hastings’ group at LMB have revealed how local body clocks control waking and sleeping
Keywords: circadian clock; suprachiasmatic nucleus (SCN); Mick Hastings; tuberomamillary nucleus (TMN); Bmal1; histamine; Xiao Yu; local body clock; histidine decarboxylase (HDC); enzyme
Photographs:Author: MRC Network
Title: Nobel Laureate appointed President Elect of the Royal Society
Reference MRC Network Spring 2015
Year: 2015
Type: Awards & Prizes
Subject: It has been announced that Venki Ramakrishnan will be the next President of the Royal Society
Keywords: Venki Ramakrishnan; Royal Society; ribosome; Aaron Klug; President
Photographs: Venki in front of the ribosomeAuthor: Cambridge News
Title: Lasting memorial at ‘Father of DNA sequencing’s’ former home
Reference Cambridge News 9 March 2015
Year: 2015
Type: Miscellaneous
Subject: Blue plaque has been installed at the former home of Fred Sanger
Keywords: Fred Sanger; blue plaque; Hills Road; Society of Biology; Julian Parkhill; Wellcome Trust; Sanger Institute; Robin Sanger; sequencing
Photographs: Robin Sanger with the plaque in backgroundAuthor: MRC Network
Title: Shining light on drug design: the power of crystallography
Reference MRC Network Autumn 2014
Year: 2014
Type: Science
Subject: Crystallography is vital for the discovery of new, powerful drugs. The technique can inform drug design by revealing the atomic structures of proteins.
Keywords: Crystallography; Patrick Maxwell; John Walker; Diamond Light Source; Heptares Therapeutics; Peter Fischer; drug design; ATP synthase; X-ray; ‘beamlines’
Photographs:Author: MRC Network
Title: Long-term science capital investment
Reference MRC Network Summer 2014
Year: 2014
Type: Funding
Subject: Chancellor of the Exchequer, the Hon George Osborne MP, visited LMB to announce details of the Government’s £7bn science capital budget
Keywords: George Osborne; Chancellor of the Exchequer; Hugh Pelham; budget: David Willets; investment; announcement
Photographs: The Chancellor with the Rt Hon David Willets MPAuthor: Ramakrishnan, Venki
Title: Testing on animals
Reference The Times Letters 7 May 2015
Year: 2015
Type: Miscellaneous
Subject: Letter to The Times from a number of Nobel laureates including Venki Ramakrishnan about the need to continue to test on animals
Keywords: Venki Ramakrishnan; animal testing; 210/63/EU; John Sulston; John Gurdon; John Walker; European Parliament; welfare; letter
Photographs:Author: Cambridge News
Title: Souvenir Edition - A day for all
Reference Cambridge News 24 May 2013
Year: 2013
Type: Events and Celebrations
Subject: Souvenir edition of the paper marking the Queens visit to Cambridge that included the opening of the new LMB building
Keywords: Queen; official opening; “cathedral of science”; new building
Photographs: Number of images of QueenAuthor: MRC Network
Title: 21st Nobel Prize for MRC-funded scientists
Reference MRC Network Winter 2014
Year: 2014
Type: Awards & Prizes
Subject: Three alumni from the LMB were awarded the 2013 Nobel Prize for Chemistry, Michael Levitt, Arieh Warshel and Martin Karplus
Keywords: Michael Levitt; Arieh Warshel; Martin Karplus; structural studies; Weizmann Institute; multi-scale models; Nobel
Photographs: Michael Levitt taken while at the LMBAuthor: MRC Network
Title: MRC recognises landmark achievement for Heptares
Reference MRC Network Winter 2014/15
Year: 2014
Type: Biotechnology
Subject: Sir John Savill presents a memento to inventors from MRC spin-out company Heptares Therapeutics to mark key US patents being granted.
Keywords: Heptares Therapeutics; John Savill; G protein-coupled receptors (GPCRs); US patents; Yoko Shibata; Tony Warne; Maria Serrano Vega; Malcolm Weir; Karen Law; Chris Tate; Richard Henderson; Francesca Magnani; MRC Technology
Photographs: Group of inventors, MRC Technology at the presentation with Sir John SavillAuthor: MRC Technology
Title: Key US Patents Granted for GPCR-Focused Drug Discovery Platform Arising From Pioneering Research and Translational Expertise at MRC and MRC Technology
Reference MRC Technology 15 December 2014
Year: 2014
Type: Biotechnology
Subject: Heptares Therapeutics a leading GPCR structure-guided drug discovery company, announced the grant of multiple key patents in the United States relating to its GPCR-focused drug discovery platform
Keywords: Haptares Therapeutics; G protein receptor (GPCR); US patent; StaR; Yoko Shibata; Tony Warne; Maria Serrano Vega; Malcolm Weir; Karen Law; Chris Tate; Richard Henderson; Francesca Magnani; MRC Technology
Photographs: Group of inventors, MRC Technology at the presentationAuthor: University of Cambridge
Title: Mechanism-based therapeutics of common human neurodegenerative diseases
Reference University of Cambridge 1 May 2015
Year: 2015
Type: Science
Subject: The LMB and the Department of Clinical Neurosciences have announced an initiative in mechanism-based therapeutics of common human neurodegenerative diseases.
Keywords: Michel Goegert; Alastair Compston; neurodegeneration; neurones; glia; Anne Bertolotti; therapies; initiative; positron emission tomography; magnetic resonance imaging
Photographs: Michel GoedertAuthor: ALZFORUM
Title: Phosphatase Inhibitor Promotes Protein Folding, Helps ALS Mice
Reference ALZFORUM 11 April 2015
Year: 2015
Type: Science
Subject: Research led by Anne Bertolotti has discovered a selective inhibitor of a phosphatase enzyme that could prevent protein misfolding diseases.
Keywords: Anne Bertolotti; Sephin 1; amyotrophic lateral sclerosis; Charcot-Marie-Tooth disease; protein phospatases 1C (PP1c); Dephoshorylation; Guanabenz; eukaryotic translation initiation factor 2α (eIF2α); multiple sclerosis; prion disease; ALS; neurodegenerative disease
Photographs:Author: Wade, Nicholas
Title: Making Sense of the Chemistry That Led to Life on Earth
Reference The New York Times 4 May 2015
Year: 2015
Type: Science
Subject: John Sutherland has determined a possible chemical pathway to produce the starting materials of life.
Keywords: Earth; Late Heavy Bombardment; cyanide; life; lipids; nucleotides; amino acids; John Sutherland; RNA; ribonucleotides; glycerol 1-phoshate; Paul J. Bracher; Steven Benner; prebiotic chemistry; Jack W. Szostak
Photographs: