Author: Borman, Stu
Title: First Pictures of the Mitoribosome Taken
Reference C&EN 3 April 2015
Year: 2015
Type: Science
Subject: Researchers, including a team from the LMB, have obtained structures of complete ribosomes from mammalian mitochondria at near-atomic resolution for the first time.
Keywords: ribosome; mitochondria; mRNA; mammalian; mitroribosomes; Venki Ramakrishnan; eukaryotic; cryo-electron microscopy; mutations; atomic resolution; cytoplasm
Photographs: Cryo-electron microscopy structure of the mitoribosomeAuthor: Isle of Man Today
Title: Body clock expert talks to students
Reference Isle of Man Today 1 April 2015
Year: 2015
Type: Miscellaneous
Subject: Michael Hastings delivers sixth form lecture at King William’s College, Isle of Man, on his research into circadian rhythms and biological clocks.
Keywords: Michael Hastings; Isle of Man; King William’s College; Ramsey Grammar School; biorhythms; body clock; circadian rhythms
Photographs: Michael Hastings with two of the studentsAuthor: Hogenboom, Melissa
Title: Crystal beauty: Illuminating the structure of matter
Reference BBC News 10 November 2014
Year: 2014
Type: Exhibitions
Subject: The LMB has played a pivotal role in the development of X-ray crystallography and the inspirational work of crystallographic scientists from round the UK is showcased in an upcoming exhibition at the Royal Albert Hall
Keywords: “illuminating Atoms”; crystallography; Royal Albert Hall; Max Alexander; Francis Crick; Jim Watson; beach; sand David Keen; Max Perutz; exhibition
Photographs: Images from the exhibitionAuthor: Biochemical Society
Title: The Colworth Medal, Member Reception and AGM
Reference Biochemical Society 1 December 2014
Year: 2014
Type: Awards & Prizes
Subject: Madan, from the LMB’s Structural Studies Division, presents his award lecture and receives the prestigious 2014 Colworth Medal at the Biochemical Society’s AGM
Keywords: Madan Babu; Colworth Medal; lecture; Charles Darwin House; celebration
Photographs:Author: Coghlan, Andy
Title: Synthetic enzymes hint at life without DNA or RNA
Reference New Scientist 1 December 2014
Year: 2014
Type: Science
Subject: Enzymes that don’t exist in nature have been made from genetic material that doesn’t exist in nature either, called XNA, or xeno nucleic acid
Keywords: Philipp Holliger; XNA; xeno nucleic acid; RNA; enzyme; life on Earth; viruses; cancer; prehistoric; synthetic biology
Photographs:Author: Connor, Steve
Title: Major synthetic life breakthrough as scientists make the first artificial enzymes
Reference The Independent 1 December 2014
Year: 2014
Type: Science
Subject: For the first time ever, researchers have made synthetic enzymes – the vital ingredients needed for life – from artificial genetic material that does not exist outside the laboratory.
Keywords: synthetic biology; Phil Holliger; life on Earth; XNA; RNA; Alex Taylor; Patrick Maxwell; enzymes; cancer; viruses; “XNAzymes”; oncogene
Photographs:Author: Wong, Sam
Title: Scientists find first evidence of ‘local’ clock in the brain
Reference Imperial College London 13 November 2014
Year: 2014
Type: Science
Subject: Research by groups at Imperial College London and Michael Hastings’ group at LMB have revealed how local body clocks control waking and sleeping
Keywords: circadian clock; suprachiasmatic nucleus (SCN); Mick Hastings; tuberomamillary nucleus (TMN); Bmal1; histamine; Xiao Yu; local body clock; histidine decarboxylase (HDC); enzyme
Photographs:Author: MRC Network
Title: Nobel Laureate appointed President Elect of the Royal Society
Reference MRC Network Spring 2015
Year: 2015
Type: Awards & Prizes
Subject: It has been announced that Venki Ramakrishnan will be the next President of the Royal Society
Keywords: Venki Ramakrishnan; Royal Society; ribosome; Aaron Klug; President
Photographs: Venki in front of the ribosomeAuthor: Cambridge News
Title: Lasting memorial at ‘Father of DNA sequencing’s’ former home
Reference Cambridge News 9 March 2015
Year: 2015
Type: Miscellaneous
Subject: Blue plaque has been installed at the former home of Fred Sanger
Keywords: Fred Sanger; blue plaque; Hills Road; Society of Biology; Julian Parkhill; Wellcome Trust; Sanger Institute; Robin Sanger; sequencing
Photographs: Robin Sanger with the plaque in backgroundAuthor: MRC Network
Title: Shining light on drug design: the power of crystallography
Reference MRC Network Autumn 2014
Year: 2014
Type: Science
Subject: Crystallography is vital for the discovery of new, powerful drugs. The technique can inform drug design by revealing the atomic structures of proteins.
Keywords: Crystallography; Patrick Maxwell; John Walker; Diamond Light Source; Heptares Therapeutics; Peter Fischer; drug design; ATP synthase; X-ray; ‘beamlines’
Photographs:Author: MRC Network
Title: Long-term science capital investment
Reference MRC Network Summer 2014
Year: 2014
Type: Funding
Subject: Chancellor of the Exchequer, the Hon George Osborne MP, visited LMB to announce details of the Government’s £7bn science capital budget
Keywords: George Osborne; Chancellor of the Exchequer; Hugh Pelham; budget: David Willets; investment; announcement
Photographs: The Chancellor with the Rt Hon David Willets MPAuthor: Ramakrishnan, Venki
Title: Testing on animals
Reference The Times Letters 7 May 2015
Year: 2015
Type: Miscellaneous
Subject: Letter to The Times from a number of Nobel laureates including Venki Ramakrishnan about the need to continue to test on animals
Keywords: Venki Ramakrishnan; animal testing; 210/63/EU; John Sulston; John Gurdon; John Walker; European Parliament; welfare; letter
Photographs:Author: Cambridge News
Title: Souvenir Edition - A day for all
Reference Cambridge News 24 May 2013
Year: 2013
Type: Events and Celebrations
Subject: Souvenir edition of the paper marking the Queens visit to Cambridge that included the opening of the new LMB building
Keywords: Queen; official opening; “cathedral of science”; new building
Photographs: Number of images of QueenAuthor: MRC Network
Title: 21st Nobel Prize for MRC-funded scientists
Reference MRC Network Winter 2014
Year: 2014
Type: Awards & Prizes
Subject: Three alumni from the LMB were awarded the 2013 Nobel Prize for Chemistry, Michael Levitt, Arieh Warshel and Martin Karplus
Keywords: Michael Levitt; Arieh Warshel; Martin Karplus; structural studies; Weizmann Institute; multi-scale models; Nobel
Photographs: Michael Levitt taken while at the LMBAuthor: MRC Network
Title: MRC recognises landmark achievement for Heptares
Reference MRC Network Winter 2014/15
Year: 2014
Type: Biotechnology
Subject: Sir John Savill presents a memento to inventors from MRC spin-out company Heptares Therapeutics to mark key US patents being granted.
Keywords: Heptares Therapeutics; John Savill; G protein-coupled receptors (GPCRs); US patents; Yoko Shibata; Tony Warne; Maria Serrano Vega; Malcolm Weir; Karen Law; Chris Tate; Richard Henderson; Francesca Magnani; MRC Technology
Photographs: Group of inventors, MRC Technology at the presentation with Sir John SavillAuthor: MRC Technology
Title: Key US Patents Granted for GPCR-Focused Drug Discovery Platform Arising From Pioneering Research and Translational Expertise at MRC and MRC Technology
Reference MRC Technology 15 December 2014
Year: 2014
Type: Biotechnology
Subject: Heptares Therapeutics a leading GPCR structure-guided drug discovery company, announced the grant of multiple key patents in the United States relating to its GPCR-focused drug discovery platform
Keywords: Haptares Therapeutics; G protein receptor (GPCR); US patent; StaR; Yoko Shibata; Tony Warne; Maria Serrano Vega; Malcolm Weir; Karen Law; Chris Tate; Richard Henderson; Francesca Magnani; MRC Technology
Photographs: Group of inventors, MRC Technology at the presentationAuthor: University of Cambridge
Title: Mechanism-based therapeutics of common human neurodegenerative diseases
Reference University of Cambridge 1 May 2015
Year: 2015
Type: Science
Subject: The LMB and the Department of Clinical Neurosciences have announced an initiative in mechanism-based therapeutics of common human neurodegenerative diseases.
Keywords: Michel Goegert; Alastair Compston; neurodegeneration; neurones; glia; Anne Bertolotti; therapies; initiative; positron emission tomography; magnetic resonance imaging
Photographs: Michel GoedertAuthor: ALZFORUM
Title: Phosphatase Inhibitor Promotes Protein Folding, Helps ALS Mice
Reference ALZFORUM 11 April 2015
Year: 2015
Type: Science
Subject: Research led by Anne Bertolotti has discovered a selective inhibitor of a phosphatase enzyme that could prevent protein misfolding diseases.
Keywords: Anne Bertolotti; Sephin 1; amyotrophic lateral sclerosis; Charcot-Marie-Tooth disease; protein phospatases 1C (PP1c); Dephoshorylation; Guanabenz; eukaryotic translation initiation factor 2α (eIF2α); multiple sclerosis; prion disease; ALS; neurodegenerative disease
Photographs:Author: Wade, Nicholas
Title: Making Sense of the Chemistry That Led to Life on Earth
Reference The New York Times 4 May 2015
Year: 2015
Type: Science
Subject: John Sutherland has determined a possible chemical pathway to produce the starting materials of life.
Keywords: Earth; Late Heavy Bombardment; cyanide; life; lipids; nucleotides; amino acids; John Sutherland; RNA; ribonucleotides; glycerol 1-phoshate; Paul J. Bracher; Steven Benner; prebiotic chemistry; Jack W. Szostak
Photographs:Author: Gray, Richard
Title: Did FROSTS lead to life on Earth? Cycles of freezing and thawing causes basic genetic material to form
Reference MailOnline 7 May 2015
Year: 2015
Type: Science
Subject: Large RNA molecules can be assembled from basic biochemical building blocks during cycles of freezing and thawing.
Keywords: severe frosts; Earth; ‘spark’; RNA-enzymes; Hannes Mutschler; hairpin ribozyme; freezing; Late Heavy Bombardment; hydrogen cyanide; lipids; toxic soup
Photographs:Author: The Francis Crick Institute
Title: A genetic switch uncovered in the long genes expressed in our brain
Reference The Francis Crick Institute 13 May 2015
Year: 2015
Type: Science
Subject: Jernej Ule, former group leader, and Vincent Plagnol from UCL have discovered a new mechanism for ‘splicing-based’ gene regulation, with possible implications for brain-related disorders.
Keywords: Jernej Ule; ‘splicing’; mRNA; introns; exons; neurodevelopmental disorders; ‘recursive sites’; Vincent Plagnol; genes; ‘cryptic sequences’
Photographs:Author: Borman, Stu
Title: New Approach to Control Enzyme Function in Cells
Reference Chemical & Engineering News 22 May 2015
Year: 2015
Type: Science
Subject: A new technique, devised by Jason Chin’s group, could make it easier to target and inhibit specific enzymes and other proteins in cells and to turn that regulation on and off at will with light.
Keywords: Jason Chin; inhibitor; enzymes; tetrazine; bioorthogonal ligand tethering; iBOLT; MEK1; MEK2; alkyne; alkene
Photographs:Author: Haar, Dan
Title: Joan A. Steitz: A Place In The Lab, and In Biochemistry History
Reference CTNOW 28 May 2015
Year: 2015
Type: History - Reminiscences
Subject: Looking at the work of LMB Alumnus Joan Steitz’s and how her time at the LMB studying ribosomes led to her important discoveries in RNA research.
Keywords: Joan Steitz; Francis Crick; James Watson; RNA; snRNPs; snurps; Thomas Steitz; ribosomes; Howard Hughes Medical Institute; Rib-X Pharmaceuticals Inc.; Melinta
Photographs:Author: Fogg, Christiana N., Kovats, Diana E.
Title: 2015 ISCB Accomplishment by a Senior Scientist Award: Cyrus Chothia
Reference Bioinformatics 22 May 2015
Year: 2015
Type: Awards & Prizes
Subject: A look at the career of Cyrus Chothia and his work on the structures and functions of proteins, following announcement of his ISCB Senior scientist award
Keywords: International Society for Computational Biology (ISCB); Cyrus Chothia; Joel Janin; Michael Levitt; John Kendrew; ‘The Thread of Life’; Arthur Lesk; SUPERFAMILY; Structural Classification of Proteins (SCOP); Tim Hubbard; Alexei Murzin; Steven Brenner; Julian Gough
Photographs: Image of Cyrus (MRC)Author: Todd Bergman, Mary
Title: Sarah Teichmann receives EMBO Gold Award
Reference EMBL etc. Lab Matters 18 June 2015
Year: 2015
Type: Awards & Prizes
Subject: Former LMB Group Leader, Sarah Teichmann, receives the 2015 EMBO Gold Award
Keywords: Sarah Teichmann; EMBO; Gold Award; Wellcome Trust Sanger Institute; EMBL; bioinformatics; Cyrus Chothia; Computational genomics
Photographs: Image of Sarah Teichmann