Author: Cambridge News
Title: Cambridge scientists unlock cause of some types of infertility
Reference Cambridge News 19 June 2015
Year: 2015
Type: Science
Subject: Melina Schuh, in collaboration with Bourn Hall Clinic, may have found the cause of some types of infertility, including recurrent miscarriage, after new research found some human eggs carry the wrong number of chromosomes.
Keywords: Melina Schuh; Bourn Hall Clinic; IVF; infertility; miscarriage; meiosis; Down’s syndrome; chromosome; aneuploid; oocytes
Photographs:Author: UK BioIndustry Association
Title: Celebrating UK bioscience
Reference UK BioIndustry Association 25 June 2015
Year: 2015
Type: Biotechnology
Subject: The stories behind three great LMB successes are highlighted in a report by the UK BioIndustry Association (BIA)
Keywords: Humira; tumour necrosis factor alpha (TNF-a); monoclonal antibody; rheumatoid arthritis; Crohn’s disease; Greg Winter; John McCafferty; “phage display”; “CDR grafting”; Cambridge Antibody Technology (CAT); David Chiswell; CAMPATH; Lemtrada; CD52; lymphocytes; multiple sclerosis; Michael Neuberger; Therapeutic Antibody Centre (TAC); Nicola Cole; G protein-coupled receptors (GPCRs); asthma; high blood pressure; schizophrenia; migraine; leukaemia; Christopher Tate; StaR®; Heptares Therapeutics; MedImmune; MorphoSys
Photographs:Author: MRC T
Title: Reviewing translation at the MRC 2014
Reference MRC T 2 July 2015
Year: 2015
Type: Biotechnology
Subject: Work by LMB’s Mike Gait, Jason Chin and Satpal Virdee, and Fabrice Gorrec highlighted in a MRC Review of recent successes in translational research
Keywords: Mike Gait; exon skipping; Duchenne muscular dystrophy; spinal muscular atrophy; myotonic dystrphy; oligonucleotide; mRNA; Pip; Penetratin; Shire; protein synthesis; Jason Chin; Satpal Virdee; Bio-Techne; Genetically encoded Orthogonal Protection and Activated Ligation (GOPAL); Ubiquitin; Morpheus® crystallisation; Fabrice Gorrec; Protein Data Bank; Molecular Dimensions Ltd
Photographs:Author: Nair, Prashant
Title: QnAs with Venki Ramakrishnan
Reference PNAS 14 July 2015
Year: 2015
Type: Miscellaneous
Subject: As Venki Ramakrishnan prepares for his upcoming presidency of the Royal Society, spoke to the journal PNAS about his plans for the future.
Keywords: Venki Ramakrishnan; The Royal Society; United States National Academy of Science; austerity; Paul Nurse; funding; J. J Thomson; William Bragg; Aaron Klug; ribosome; President Elect; PNAS; Europe; GDP
Photographs: Image of Venki RamakrishnanAuthor: Van Noorden, Richard; Maher, Brendan; Nuzzo, Regina
Title: The Top 100 Papers
Reference Nature 30 October 2014
Year: 2014
Type: Science
Subject: Nature explores the most-cited research of all time
Keywords: Nature; Thomson Reuters; Web of Science; Fred Sanger; citations; protein biochemistry; DNA-sequencing method; bioinformatics; Uli Laemmli; bacteriophage; Steve Nicklen; Alan Coulson; Georges Köhler; Milstein Cesar; top papers
Photographs:Author: Ward, Lucy
Title: Venki Ramakrishnan on leaving the EU, science in schools - and horoscopes
Reference The Guardian 17 June 2015
Year: 2015
Type: Miscellaneous
Subject: Venki Ramakrishnan, the incoming president of the Royal Society, shares his hopes for British science
Keywords: Venki Ramakrishnan; the Royal Society; EU; ribosome; Paul Nurse; Europe; referendum; public engagement; GDP; funding; austerity; immigration; Max Perutz; European Research Council; horoscopes; homeopathy
Photographs:Author: Gallagher, James
Title: Poor sleeping patterns link to cancer
Reference BBC News 21 July 2015
Year: 2015
Type: Science
Subject: A study suggests that irregular sleeping patterns have been “unequivocally” shown to lead to cancer in tests on mice.
Keywords: Current Biology; breast cancer; body clock; Michael Hastings; circadian rhythm; shift work
Photographs:Author: Sharma, Anuradha
Title: India needs to invest in infrastructure: Venkatraman Ramakrishnan
Reference The Indian Express 26 July 2015
Year: 2015
Type: Miscellaneous
Subject: Venki talks about climate, and why individuals cutting down on their energy consumption will not be enough.
Keywords: Venki Ramakrishnan; climate change; United Nations; India; China; global emissions; solar power; Royal Society
Photographs: Venki with his son in MumbaiAuthor: EMBO encounters
Title: Phosphatase inhibitor prevents protein-misfolding disease
Reference EMBO encounters Summer 2015
Year: 2015
Type: Science
Subject: Highlighting EMBO member Anne Bertolotti’s paper in science about modification of medicine for high blood pressure into one that might tame misfolded protein disease
Keywords: Anne Bertolotti; Sephin 1; amyotrophic lateral sclerosis; Charcot-Marie-Tooth disease; EMBO; R15A phosphatase
Photographs: Image of Anne BertolottiAuthor: Martynoga, Ben
Title: How to grow a ‘brain’
Reference MRC Insight 2 July 2015
Year: 2015
Type: Science
Subject: A look at Madeline Lancaster’s research growing rudimentary brain tissue in the lab which means that researchers can study organ development and disease. But how do you go from stem cells to a ‘mini-brain’
Keywords: Madeline Lancaster; ‘mini-brain’; cerebral organoids; microcephaly; stem cells; glial cells; Long + Short
Photographs: A cross-section of a cerebral organoid or ‘mini-brain’ (Image copyright: IMBA/ Madeline A. Lancaster)Author: Pain, Elizabeth
Title: Harnessing computer power to understand biology
Reference Science 7 July 2015
Year: 2015
Type: Career Structure
Subject: Former LMB Group Leader Sarah Teichmann talks about how she was inspired by computational biology by Cyrus Chothia, with whom she did her PhD.
Keywords: Sarah Teichmann; EMBL-EBI; European Molecular Biology Organization Gold Medal; Wellcome Trust Sanger Institute; bioinformatics; Cyrus Chothia; computational biology; Ras; career; ‘wet-dry’
Photographs: Sarah Teichmann and her groupAuthor: Hesman Saey, Tina
Title: The origin of biological clocks
Reference Science News 14 July 2015
Year: 2015
Type: Science
Subject: Review of research, including that of the LMB’s John O’Neill, on the evolutionary story of circadian rhythms.
Keywords: circadian clocks; John O’Neill; “flight from light”; UV Light; cyanobacteria; Akhilesh Reddy; Clock; Timeless; Period; Peroxiredoxins; KaiA; Kinase;
Photographs:Author: Marks, Lara
Title: Monoclonal antibodies: the invisible allies that changed the face of medicine
Reference The Conversation 10 August 2015
Year: 2015
Type: History - Reminiscences
Subject: The technique for producing monoclonal antibodies was first published 40 years ago by César Milstein and Georges Köhler, at the LMB.
Keywords: César Milstein; Georges Köhler; Monoclonal antibodies (Mabs); immune system; “magic bullets”; rheumatoid arthritis; multiple sclerosis; cancer; asthma; Alzheimer’s disease; diabetes; autoimmune; diagnostic testing; genentech
Photographs: Preparation of monoclonal antibodies in the lab; An artist’s rendering of anti-cancer antibodies; Monoclonal antibodies can be used to rapidly diagnose disease and determine blood type.Author: Phys Org
Title: New details of the transmission of stimuli in living organisms unveiled
Reference Phys Org 11 August 2015
Year: 2015
Type: Science
Subject: A team lead by the Paul Scherrer Institute (PSI) and ETH Zurich together with Madan Babu Mohan’s group and the pharmaceutical company Roche provide new details of how the activation of G-protein-coupled receptors takes place and demonstrate that only a few amino acids have a major influence on GPCR function.
Keywords: G-protein; stimuli; Paul Scherrer Institute (PSI); ETH Zurich; Roche; Madan Babu Mohan; Rhodopsin; Dmitry Veprintsev; Gebhard Schertler; adrenalin
Photographs:Author: IUCr
Title: The MORPHEUS II protein crystallization screen
Reference IUCr 18 August 2015
Year: 2015
Type: Science
Subject: Fabrice Gorrec from the LMB has published developments related to MORPHEUS II – a protein crystallization screen. He has demonstrated that additives selected from the PDB that are under-represented in traditional screens can be combined to formulate suitable and useful conditions, not only for crystallization but the overall structure determination process.
Keywords: MORPHEUS II; Fabrice Gorrec; X-ray diffraction; crystallization screen; protein stabilizers; polyols; cryoprotectant
Photographs:Author: Nightingale, Katherine
Title: From tool to therapy: a timeline of monoclonal antibody technology
Reference MRC Insight 17 August 2015
Year: 2015
Type: History - Reminiscences
Subject: Forty years ago this month, Nature published a paper by the LMB’s César Milstein and Georges Köhler which described how they’d made mouse monoclonal antibodies. Here we look at the landmarks on the 40-year journey
Keywords: César Milstein; Georges Köhler; monoclonal antibodies; ‘humanised’; Campath-1H; Greg Winter; Michael Neuberger; Marianne Brüggemann; ‘phage display’; Cambridge Antibody Technology; alemtuzumab; rheumatoid arthritis; Humira; multiple sclerosis
Photographs: César Milstein and Georges Köhler; Greg WinterAuthor: Oakley, Deborah
Title: Worming our way to a new understanding of behaviour
Reference MRC Clinical Sciences Centre 21 August 2015
Year: 2015
Type: Science
Subject: The wriggling and writhing of worms may hold clues to the inner workings of our brains, according to scientists at the MRC’s Clinical Sciences Centre and their collaborators at the LMB.
Keywords: wriggling; writhing; nematode worm; European Bioinformatics Institute (EMBL-EBI); dopamine; serotonin; Bill Schafer
Photographs:Author: Rae Chi, Kelly
Title: Orchestrating Organoids: A guide to crafting tissue in a dish that reprise in vivo organs
Reference The Scientist 1 September 2015
Year: 2015
Type: Science
Subject: Madeline Lancaster’s method of growing organoids to understand early brain development is featured in this “guide to crafting tissues in a dish that reprise in vivo organs”
Keywords: mini-guts; organoids; brain beads; Madeline Lancaster; stem cells; Matrigel; neurodegenerative disease; RT-PCR; Parkinson’s; Alzheimer’s; autism
Photographs: Image - Neuronal NexusAuthor: Callaway, Ewen
Title: The revolution will not be crystallized: a new method sweeps through structural biology
Reference Nature 9 September 2015
Year: 2015
Type: Science
Subject: Highlight of the work of Richard Henderson, Nigel Unwin and Sjors Scheres in developing cryo-EM techniques that are changing the way scientists solve molecular structures.
Keywords: Cryo-electron microscopes; Sjors Scheres; X-ray crystallography; cryo-EM; Alzheimer’s; Richard Henderson; Nigel Unwin; bacteriorhodopsin; Venki Ramakrishnan
Photographs:Author: Harrop, Sarah
Title: Behind the picture: Sir John Sulston’s worm cell drawing
Reference MRC Insight 23 September 2015
Year: 2015
Type: History - Reminiscences
Subject: The story behind a lab notebook entry which contributed to a Nobel Prize-winning breakthrough
Keywords: John Sulston; lab notebook; nematode worm; hand-drawings; c. elegans; Sydney Brenner; John White; cell death; Genome
Photographs: A page from John Sulston’s 1980 lab notebook showing his cell-tracking method (Wellcome image)Author: MRC News
Title: 2015 Max Perutz Science Writing Award shortlist announced
Reference MRC News 22 September 2015
Year: 2015
Type: Awards & Prizes
Subject: Barry Bentley, a PhD student in Neurobiology, is one of 14 exceptional writers to be shortlisted for the Max Perutz Science Writing Award
Keywords: Max Perutz; Science Writing; Barry Bentley; Award; “The Worm Wide Web”
Photographs:Author: Churchill College
Title: Dr Alexey Amunts recognised for revolutionary work in the field of molecular biology
Reference Churchill College News 8 October 2015
Year: 2015
Type: Awards & Prizes
Subject: The LMB’s Alexey Amunts has been awarded the 2015 George Palade Award by the Microscopy Society of America for distinguished contributions to the field of microscopy and microanalysis in the life sciences.
Keywords: Alexey Amunts; George Palade award; microscopy; microanalysis; cryo-EM; macromolecules; protein synthesis; mitochondria; the Microscopy Society of America (MSA)
Photographs: President of the Microscopy Society of America presenting award to Alexey Amunts.Author: Parrish, Meagan
Title: 11 Fun Factoids About The Nobel Prize in Chemistry
Reference Chem Info 10 June 2015
Year: 2015
Type: Awards & Prizes
Subject: 11 factoids about the Nobel Prize in Chemistry including the number of prizes won by LMB
Keywords: Nobel Prize; Alfred Nobel; Chemistry Laureates; Michael Levitt
Photographs:Author: Roy, Amit
Title: Science and star power mix - Nicole does justice to an ‘injustice’
Reference The Telegraph (India) 15 September 2015
Year: 2015
Type: History - Reminiscences
Subject: Review in the Telegraph, India of Nicole Kidman in the play Photograph 51 and the background to the story.
Keywords: Nicole Kidman; Photograph 51; X-ray diffraction; Rosalind Franklin; Venki Ramakrishnan; Maurice Wilkins; Francis Crick; James Watson; play; King’s College London
Photographs: Nicole Kidman as Rosalind Franklin in Photograph 51; Image of Rosaling FranklinAuthor: Moody, Oliver
Title: Why an after-dinner espresso could mess you up for weeks
Reference The Times 17 September 2015
Year: 2015
Type: Science
Subject: Research that was jointly done with John O’Neill’s group finds that strong coffee three hours before bedtime could set the biological clock back by 40 minutes.
Keywords: John O’Neill; coffee; caffeine; melatonin; sleep; body clock; circadian; jet lag; espresso
Photographs: