Author: Brackley, Paul
Title: LMB solves structure of ALS molecule to aid hunt for drugs
Reference Cambridge Independent 23 December 2021
Year: 2021
Type: Science
Subject: The structure of the molecule associated with ALS has been determined for the first time by Ben Ryskeldi-Falcon’s Group
Keywords: Amyotrophic lateral sclerosis (ALS); Motor neurone disease; Clumped TDP-43; Alzheimer’s disease; Parkinson’s; Benjamin Ryskeldi-Falcon; Diana Arseni; Alexey Murzin; cryo-EM; amyloid filaments; tau; alpha-synuclein; FTD; neurodegenerative disease; ‘aggregates’
Photographs: Image of Ben; Image of Clumped TDP-43 (MRC-LMB)Author: Cambridge Network
Title: First detailed images captured of molecule associated with ALS
Reference Cambridge Network 10 December 2021
Year: 2021
Type: Science
Subject: The structure of the molecule associated with ALS has been determined for the first time by Ben Ryskeldi-Falcon’s Group
Keywords: Amyotrophic lateral sclerosis (ALS); TDP-43; cryo-EM; Benjamin Ryskeldi-Falcon; neurodegenerative disease; clumping; aggregates
Photographs:Author: LifeArc
Title: LifeArc’s technology transfer team supports MRC researchers in making cryo-electron microscopy even sharper
Reference LifeArc 3 November 2021
Year: 2021
Type: Science
Subject: LifeArc filed applications for a patent and trademark for the new all-gold grids developed by Chris Russo’s group. Helping to bring them to the marked as soon as possible.
Keywords: cryo-EM; gold grids; HexAuFoil; Chris Russo; LifeArc; ‘cryoEvap’; gold film
Photographs: Picture of gold grid (MRC LMB)Author: Blakely, Rhys
Title: Man-made cell that produces plastics and medicines hailed as revolutionary in biology
Reference The Times 4 June 2021
Year: 2021
Type: Science
Subject: Jason Chin’s group have created a new type of cell capable of producing substances such as plastics and medicines in a way not seen in the natural world
Keywords: Jason Chin; biodegradable plastics; antibiotics; synthetic chemistry; polymers; codons; tRNA; monomers; polymers; genome; genetic code; amino acid; bacteria
Photographs:Author: Brackley, Paul
Title: Discovery over receptors could change our understanding of molecular neuroscience
Reference Cambridge Independent 8 April 2022
Year: 2022
Type: Science
Subject: A recent paper from Radu Aricescu’s group was a structural investigation into type A gamma-aminobutyric acid receptors has found that their subunit arrangements are far more varied than previously thought
Keywords: Radu Aricescu; GABAA receptors; type A gamma-aminobutyric acid receptors; Andrija Sente; Jonas Miehling; Tomas Malinauskas; Wellcome Centre for Human Genetics; cryo-EM; Katerina Naydenova; computational strategy; signalling; drug targets; central nervous system; inhibitory neurotransmission; ‘action potential’; neuron
Photographs: Scientific image of GABAA receptors (MRC LMB)Author: ALZFORUM
Title: Suprise! TMEM106b Fibrils Found in Neurodegenerative Disease
Reference ALZFORUM 12 April 2022
Year: 2022
Type: Science
Subject: Alzforum summarises three recent papers which analysed TMEM106b amyloid filaments in the human brain – including research from Sjors Scheres’ and Michel Goedert’s groups in the LMB’s Structural Studies and Neurobiology Divisions respectively
Keywords: David Eisenberg; TDP-43; TMEM106b fibris; Michel Goedert; Sjors Scheres; neurodegenerative disease; FTLD-TDP; cryo-EM; “fuzzy coat”; Benjamin Ryskeldi-Falcon; C-terminal fragment; ultracentrifugation; TMEM239; antibody
Photographs:Author: bicycle therapeutics Press Release
Title: Bicycle Therapeutics announces updated preclinical data on SARS-CoV-2 antivirals at the 2022 microbiology society annual meeting
Reference bicycle therapeutics 7 April 2022
Year: 2022
Type: Science
Subject: Bicycle Therapeutics reports on its updated preclinical data produced in collaboration with Leo James’ group. In vitro tests of their proprietary bicyclic peptide show promise for antiviral modality against SARS-CoV-2
Keywords: Bicycle Therapeutics; biotechnology; SARS-CoV-2; Microbiology Society Annual Meeting; Leo James; preclinical data; anti-viral; bicycle Toxin Conjugate
Photographs:Author: DZNE
Title: “Hartwig Piepenbrock-DZNE Prize” Honors Research on Brain Diseases
Reference DZNE 16 May 2022
Year: 2022
Type: Awards & Prizes
Subject: To mark the award of the Hartwig Piepenbrock-DZNE Prize for his ground-breaking research into the molecular basis of neurodegenerative diseases, DZNE have released a video portrait of Michel Goedert
Keywords: Michel Goedert; neurodegenerative disease; Hartwig Piepenbrock-DZNE Prize; Alzheimer’s; Parkinson’s; Hartwig Piepenbrock-DZNE; tau; alpha-synuclein protein
Photographs: Michel receiving the prizeAuthor: Nature
Title: Hot headed: brain temperature can exceed 40 degrees
Reference Nature 23 June 2022, p.627
Year: 2022
Type: Science
Subject: Magnetic resonance spectroscopy allowed Nina Rzechorzek (member of the O’Neill group, Cell Biology) and collaborators to create a HEATWAVE map
Keywords: Temperature; brain; Nina Rzechorzek; John O’Neill; scans; 40ºC; traumatic brain injury; rises and falls
Photographs: Image showing the different temperature of male and female brains. (MRC-LMB)Author: Biochemical Society
Title: 2023 Award Winners Biochemical Society
Reference Biochemical Society 7 April 2022
Year: 2022
Type: Alumni - Awards & Prizes
Subject: Stephen Wallace has been awarded The Colworth Medal, given by The Biochemical Society to recognise outstanding research by a biochemist within 10 years of PhD completion
Keywords: Biochemical Society’s Awards 2023; Stephen Wallace; Colworth Medal; Jason Chin; alumni
Photographs:Author: Laurans, Penelope
Title: Sidney Altman, pathbreaking scientist
Reference YaleNews 6 April 2022
Year: 2022
Type: Alumni - Obituary
Subject: Sidney Altman was a ground-breaking scientist in the field of RNA biology, whose discovery of catalytic properties of RNA led to the award of the Nobel Prize in Chemistry in 1989
Keywords: Sidney Altman; catalytic properties; RNA; Sydney Brenner; Francis Crick; Yale; alumni
Photographs: Image of Sidney AltmanAuthor: Snyder, Bill
Title: Lehmann named to receive Vanderbilt Prize in Biomedical Science
Reference Vanderbilt University Medical Centre 20 April 2022
Year: 2022
Type: Alumni - Awards & Prizes
Subject: Ruth Lehmann is the 2022 recipient of the Vanderbilt Prize in Biomedical Science, and she was a Postdoctoral Visitor with Michael Wilcox and Peter Lawrence in the Cell Biology Division.
Keywords: Ruth Lehmann; Director Whitehead Institute for Biomedical Research; alumni; Cell Biology; Vanderbilt Prize in Biomedical Sciences; fruit fly Drosophila; germ cells
Photographs: Image of Ruth LehmannAuthor: Ananthasubramaniam, Bharath
Title: Introducing the next SRBR Public Outreach Fellow
Reference Society for Research on Biological Rhythms 30 June 2022
Year: 2022
Type: Career Structure
Subject: Andrew Beale, a postdoc in John O’Neill’s group in the Cell Biology Division, discusses his plans as new Public Outreach Fellow for the Society for Research on Biological Rhythms (SRBR),
Keywords: Andrew Beale; John O’Neill; SRBR Public Outreach Fellow; biological rhythms; Circadian rhythms; public engagement; chronobiology; temperature sensitivity; Clockbites
Photographs: Head shot of Andrew BealeAuthor: Stemm, Holly
Title: Student to success story: Our Undergraduate Research Opportunity Program
Reference CSIROscope 18 July 2022
Year: 2022
Type: Career Structure
Subject: Ben Porebski, an Investigator Scientist in Philipp Holliger’s group in PNAC Division, discusses his career so far
Keywords: Ben Porebski; Undergraduate Research Opportunity Program (UROP); real-world experience; biomedical; Computer sciences; wet lab; CSIRO; Australia; “mixed placement’
Photographs: Ben Porebski in the lab (MRC-LMB)Author: Malins, Abi
Title: Inja Radman
Reference WATT 11 August 2022
Year: 2022
Type: Alumni- Career Structure
Subject: Inja Radman discusses her career so far with Women Ahead of Their Time (WATT), including the “fantastic time” she spent as a PhD student and Investigator Scientist in Jason Chin’s group
Keywords: Inja Radman; biotech; Silicon Valley; genetics; Summer School of Science; Jason Chin; Synthetic Biology; WATT; IndieBio; New Culture; Matt Gibson; cellular agriculture;
Photographs: Head shot of Inja RadmanAuthor: Kilmartin J. V., Crowther R. A.
Title: Vernon Martin Ingram - Biographical Memoirs
Reference Royal Society Memoirs 10 August 2022
Year: 2022
Type: Alumni - Obituary
Subject: Vernon Ingram Royal Society Biographical Memoir, written by emeritus scientists John Kilmartin and Tony Crowther.
Keywords: Vernon Ingram; X-ray crystallography; sickle cell haemoglobin; neurodegenerative disease; heavy atom; Max Perutz; Cavendish Laboratory; John Kendrew; Francis Crick; thalassaemia; erythroleukaemia cells; HeLa; Alzheimer’s disease; Huntington’s disease
Photographs:Author: The Royal Society
Title: Francis Crick Medal and Lecture 2023 winner
Reference The Royal Society 26 August 2022
Year: 2022
Type: Alumni - Awards & Prizes
Subject: Tiago Branco is the 2023 recipient of The Royal Society’s Francis Crick Medal and Lecture in recognition of his research into molecular, cellular and circuit bases of neuronal computation.
Keywords: Tiago Branco; Francis Crick Medal; neuronal computation; animal decision behaviour; award; alumni; Royal Society
Photographs:Author: Breakthrough Prize
Title: Winners of the 2023 Breakthrough Prizes in Life Sciences, Mathematics and Fundamental Physics announced
Reference Breakthrough Prize 23 September 2022
Year: 2022
Type: Alumni - Awards & Prizes
Subject: Anthony Hyman has been jointly awarded the 2023 Breakthrough Prize for Life Sciences. Anthony, along with Clifford Brangwynne, discovered an entirely new mechanism for cellular organisation that concentrates cellular interactions between proteins and other biomolecules in membraneless droplets
Keywords: Breakthrough Prize; Anthony A. Hyman; Life Sciences Prize; “Oscars of Science”; Award; Priscilla Chan; Mark Zuckerberg; Alumni
Photographs:Author: Roche, Elise
Title: The art of being a nutraceuticals scientist
Reference Food Matters live 28 September 2022
Year: 2022
Type: Alumni- Career Structure
Subject: Miriam Ferrer discusses her career to date, including her time at the LMB and how her passion for science was ignited by a documentary about DNA’s double helix
Keywords: Miriam Ferrer; Cambridge Nutraceuticals; supplements; double helix; genetic engineering; BRCA1; Abcam; Alumni; career
Photographs:Author: Cambridge Independent
Title: Kelly Nguyen earns Colworth Medal
Reference Cambridge Independent, 19 April 2023
Year: 2023
Type: Awards and prizes
Subject: Kelly Ngyuyen awarded the Colworth medal by the Biochemical Society 2024
Keywords: Kelly Ngyuyen Colworth Medal Biochemical Society Kiyoshi Nagai Telomeres
Photographs: Kelly Nguyen LMB group photoAuthor: Mike Scialom
Title: Bicycle therapeutics and Novarts in $1.7bn cancer remedies goal
Reference Cambridge Independent 5 April 2023
Year: 2023
Type: Biotechnology company
Subject: Bicycle Therapeutics collaboration with Novartis to discover and develop multiple targeted radiogand therapies in oncology
Keywords: Bicycle Therapeutics Novartis Oncology Greg winter Christian Heinis
Photographs: Kevin lee (CEO)Author: Paul Brackley
Title: TB treatment time could be slashed by heartburn drugs
Reference Cambridge Independent 08 February 2023
Year: 2023
Type: Science
Subject: Heartburn drugs could shorten treatment of TB
Keywords: Lalita Ramakrishnan TB Heartburn
Photographs: Lalita Ramakrishnan MRC LMBAuthor: Paul Brackley
Title: Brown fat breakthrough could aid obesity and diabetes
Reference Cambridge Independent 7 June 2023
Year: 2023
Type: Alumni; Science
Subject: Significant breakthrough made in search for treatments for obesity and diabetes.
Keywords: Paul Brackley Brown fat Diabetes Edmund Kunji
Photographs:Author: Cambridge Independent
Title: Alzheimers’s award for LMB scientist
Reference Cambridge independent 22 February 2023
Year: 2023
Type: Awards and prizes; Science
Subject: Benjamin won Alzheimer’s award in 2022 for outstanding research in neurodegenerative diseases
Keywords: Benjamin Ryskeldi-Falcon Alzheimer’s Neurodegenerative Award
Photographs: Keith HeppellAuthor:
Title: First map of insect larva brain is a ‘landmark achievement’
Reference Cambridge Independent 15 March 2023
Year: 2023
Type: Science
Subject: The first map to show every neuron in the brain of fruit fly larva and how they are wired as been created by LMB scientists.
Keywords: Fruit Fly Marta Zlatic Albert Cardona Brain
Photographs: MRC LMB