On day 121 of #LMB365 we have a 1970s image of the nematode worm, C. elegans, to highlight Sydney Brenner’s landmark paper on the genetics of Caenorhabditis elegans which was published in May 1974: Genetics 77: 71-94. “The ease of handling of the nematode coupled with its small genome size suggests that it is feasible to look for mutants in all of the genes to try to discover how they participate in the development and functioning of a simple multicellular organism.” For this work, Sydney shared the 2002 Nobel Prize for Physiology or Medicine