It is generally thought that abnormal proteins aggregate, the aggregates get ubiquitinated, and this leads to their degradation by autophagy or the proteasome. Hugh Pelham’s group in Cell Biology has been working on ubiquitination of protein condensates by Nedd4 ubiquitin ligases. These images for day 227 of #LMB365 show that artificial protein condensates (green, left) do not recruit NEDD4 ubiquitin ligase (red), unless they contain a PY motif (right).
MRC Laboratory of Molecular Biology
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