LMB 365 – Day 237

On day 237 of #LMB365 is a model of the structure of the enzyme, F1-ATPase. The structure was first published one this day in 1994 in a landmark paper in Nature. F1-ATPase is the catalytic component of ATP synthase, the enzyme responsible for the synthesis of ATP in living cells. The gamma subunit (blue) is believed to rotate within the three alpha (red) and three beta (yellow) subunits during catalysis. For his work in solving this structure John Walker shared the 1997 Nobel Prize in Chemistry. Jan Pieter Abrahams, Andrew G. W. Leslie, René Lutter; John E. Walker. Structure at 2.8 angstrom resolution of F1-ATPase from bovine heart mitochondria. Nature 370: 621-628, 1994