LMB 365 – Day 246

Day 246 of #LMB365 is an artistic representation of a synthetic bacterium, by artist Larissa Ulisko. Jason Chin’s group computationally designed and synthesised anE. coligenome where all instances of three codons have been replaced by their synonymous counterparts in annotated genes. The bacterium’s natural genome was then replaced, step-by-step, by the synthetic version, yielding a living cell with a completely rewritten genome.