In the spotlight on day 277 of #LMB365 is Richard Henderson who won the 2017 Nobel Prize in Chemistry. Speaking to the press in the LMB lecture theatre on the day of the announcement, accompanied by then LMB Director Hugh Pelham, it was the first of many press enquiries Richard undertook. He summed up the importance of the technique he helped to develop as “the big thing about cryo-EM is that you can use it for determining all the other unknown structures that have been intractable by the other methods”