Day 289 of #LMB365 is an image from Costa Televantos in Lalita Ramakrishnan’s group of a granuloma from a fish infected with Mycobacterium marinum. In this image, macrophages (a type of white blood cell responsible for controlling infection) are fluorescent, with green nuclei and a red cytosol and are infected with blue bacteria. The early stage ofMycobacterium marinuminfection in zebrafish models that ofMycobacterium tuberculosisin humans. The group utilise the genetic tractability and optical transparency of the zebrafish to influence and monitor the progression of infection.
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