This image for day 309 of #LMB365 shows mouse fibroblasts where surface receptors have been clustered into spots using new synthetic polymers. Imaging is performed using sub-cellular light sheet microscopy, a state-of-the-art microscopy technique established at the LMB by James Manton, that is able to resolve cellular details with unprecedented temporal resolution. The Derivery lab is using this technique to study the molecular mechanisms of endocytosis and trafficking of receptors and cell fate determinants in cells.
MRC Laboratory of Molecular Biology
One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.