Day 329 of #LMB365 shows the cryo-EM structure of the human 20S proteasome bound to PA200. This provides significant new information on this important but still poorly studied protein complex located in the nucleus of cells. This structure, by Ana Toste Rêgo and Paula da Fonseca, was determined by the analysis of a sample obtained by the recombinant co-expression of all the complex 15 constitutive subunits together with its 5 dedicated assembly chaperones
MRC Laboratory of Molecular Biology
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