Day 331 of #LMB365 shows a submarine mini gel, originally designed by Greg Winter. The design was inspired by seeing Russian gels at a sequencing course in Poland. Greg first made a version in an old filter box, glueing in platinum wires taken from obsolete equipment. He caste the gel between spacers, which like the well comb were set into notches on the side of the box. This provided a very quick and convenient way of making regular and reproducible gels to check plasmids/restriction digests. This prototype was made into a safe and easy-to-use version by the LMB Workshop and proved invaluable in Greg’s recombinant DNA work and is now a mainstay of the LMB. Greg has donated this replica of the original 1984 version to the Nobel Museum, following his 2018 Nobel Prize for Chemistry
MRC Laboratory of Molecular Biology
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