Day 342 of #LMB365 shows PhD student, Elyse Fischer, loading her sample into the column of one of the LMB’s FEI Titan Krios microscopes. Protein samples frozen on grids in amorphous ice are placed inside a nanocap. Upon insertion of the nanocap, a mechanical arm is activated which brings the samples into an autoloader. This streamlines grid screening and data collection as up to 12 grids can be exchanged into the column with just a press of the button.