Science is all about success as well as failure and many experiments don’t work. Dealing with failure in a constructive way is a vital skill that scientists develop throughout their career. On day 357 of #LMB365, a postdoc lost his purified protein due to a machine malfunction after spending hours in the cold room trying to save it. While he felt great disappointment, he also made the best of the situation by applying his sense of humour to the situation at hand. A great example of failing gracefully!