On day 361 of #LMB365 we have an immunofluorescence photomicrograph of blood cells in murine spleen by Ashley Kamimae-Lanning in the PNAC Division. Shown are B cells (green) and T cells (red) in germinal centres of the spleen, with cell nuclei in blue and red blood cells appearing yellow. The Patel Lab studies how metabolism and DNA repair together form two tiers of protection against DNA-damaging aldehydes, which are produced in the body and environment. Blood stem & progenitor cells, which give rise to all blood cells over a lifetime, are particularly susceptible to damage from aldehydes when these tiers of protection are removed or are overwhelmed.
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