New Approach To Control Enzyme Function In Cells

A new technique, devised by Jason Chin’s group, could make it easier to target and inhibit specific enzymes and other proteins in cells and to turn that regulation on and off at will with light. Bioorthogonal ligand tethering, or BOLT, has been used to create an inhibitor that can regulate the activity of a target enzyme selectively, an approach called iBOLT. More…