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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Home > LMB In The News > Researchers “drug the undruggable”

Researchers “drug the undruggable”

Published on 20 October, 2017

A new approach to targeting key cancer-linked proteins, thought to be ‘undruggable’, has been discovered through an alliance between industry and academia created by Cancer Research UK.  David Komander’s group in the LMB is one of the groups involved in this unique collaboration, that shows that two novel and specific small-molecule inhibitors developed by the alliance can bind to and deactivate an enzyme that controls the stability of the p53 tumour suppressor protein. This deactivation allows p53 to be turned on, putting the brakes on cancer growth. More…

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