Scientists establish a comprehensive protein interactions map of the replication machinery of a chronic virus

Chronic viral infections are amongst the biggest threats to human health worldwide. Leo James’ group from the LMB’s PNAC Division, in collaboration with scientists at the Austrian Academy of Sciences and University of Basel, have established the first comprehensive overview of cellular proteins interacting with the LCMV polymerase. It is hoped that the research leads to a better understanding of how chronic viral infections start and the complex molecular interactions between viruses and their hosts. More…