Sean Munro: Revealing the Golgi’s true identity

“Although cargo proteins move through the different organelles of the secretory pathway, other proteins remain in place to give each compartment its own unique identity and function. Sean Munro, from the MRC Laboratory of Molecular Biology in Cambridge, England, has been interested in how proteins find their place within the secretory pathway since his PhD studies with Hugh Pelham, when he discovered a heat-shock protein that was retained in the ER lumen due to a specific KDEL sequence at its C terminus.” More…