MRC Laboratory of Molecular Biology

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Trim-Away: a new technique for depleting proteins and studying their function

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Dean Clift from Leo James’ group, in collaboration with LMB alumnus Melina Schuh at the Max Planck Institute, have developed a new technique – Trim-Away – which allows proteins to be rapidly depleted from cells. By harnessing the cells’ protein degradation machinery and TRIM21, the scientists have provided a new technique for studying protein function. More…