Langevin F, Crossan GP, Rosado IV, Arends MJ, Patel KJ (2011)
Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice.
Nature, 475:53-58.
Crossan GP, van der Weyden L, Rosado IV, Langevin F, Gaillard PH, McIntyre RE; Sanger Mouse Genetics Project, Gallagher F, Kettunen MI, Lewis DY, Brindle K, Arends MJ, Adams DJ, Patel KJ (2011)
Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia.
Nature Genetics, Feb;43:147-52.
Pace P, Mosedale G, Hodskinson MR, Rosado IV, Sivsubraminium M, Patel KJ (2010)
Ku70 corrupts DNA repair in the absence of the Fanconi Anaemia pathway.
Science, Jul 9;329 (5988):219-23.
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Postdoc position available in KJ Patel's Lab
Group Members
- Frederic Langevin
- Ivan Rosado
- Gerard Crossan
- Michael Hodskinson
- Juan Garaycoechea
- Nina Oberbeck
- Lucas Pontel
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We aim to understand the molecular basis of chromosome stability in human cells. Genetic predisposition to cancer is commonly precipitated by mutations in genes that result in chromosome breakage.
Studies of the inherited chromosomal instability diseases in humans have led to the discovery of some of these genes, and the characterization of their products may profoundly contribute to our understanding of pathways that maintain genetic integrity.
By utilising a variety of complementary approaches, we are probing the function of these essential proteins.
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Group Leaders 
