We aim to understand the molecular basis of chromosome stability in human cells. Genetic predisposition to cancer is commonly precipitated by mutations in genes that result in chromosome breakage.
Studies of the inherited chromosomal instability diseases in humans have led to the discovery of some of these genes, and the characterization of their products may profoundly contribute to our understanding of pathways that maintain genetic integrity.
By utilising a variety of complementary approaches, we are probing the function of these essential proteins.
- Langevin, F., Crossan, G.P., Rosado, I.V., Arends, M.J. and Patel, K.J. (2011)
Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice.
Nature 475: 53-58.
- Crossan, G.P., van der Weyden, L., Rosado, I.V., Langevin, F., Gaillard, P.H., McIntyre, R.E., Sanger Mouse Genetics Project, Gallagher, F., Kettunen, M.I., Lewis, D.Y., Brindle, K., Arends, M.J., Adams, D.J. and Patel, K.J. (2011)
Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia.
Nature Genetics 43: 147-52.
- Pace, P., Mosedale, G., Hodskinson, M.R., Rosado, I.V., Sivsubraminium, M. and Patel, K.J. (2010)
Ku70 corrupts DNA repair in the absence of the Fanconi anaemia pathway.
Science 329: (5988):219-23.
- Frederic Langevin
- Gerard Crossan
- Michael Hodskinson
- Juan Garaycoechea
- Nina Oberbeck
- Lucas Pontel
- Jan Silhan
- Lee Mulderrig
- Guillermo Burgos Barragan
- Joo-Hee Sir
- Maya Petek