Donnelly C. M., Stewart M., Roby J. A., Sundaramoorthy V., Forwood J. K.
Structural Determination of the Australian Bat Lyssavirus Nucleoprotein and Phosphoprotein Complex
Viruses 16(1):33DOI: 10.3390/v16010033
PMID: 38229694
PMCID: PMC7615531
Date of Paper: 01/12/2023
Division: Structural StudiesLövestam S,. Li D., Wagstaff J. L., Kotecha A., Kimanius D., McLaughlin S. H., Murzin A. G., Freund S. M. V, Goedert M., Scheres S. H. W.
Disease-specific tau filaments assemble via polymorphic intermediates
Nature 625(7993):119-125DOI: 10.1038/s41586-023-06788-w
PMID: 38030728
PMCID: PMC10764278
Date of Paper: 29/11/2023
Division: Structural StudiesDrehmann P., Milanos S., Schaefer N., Kasaragod V., Herterich S, Holzbach-Eberle U., Harvey R. J.
Dual role of dysfunctional Asc-1 transporter in distinct human pathologies - human startle disease and developmental delay
eNeuro 0263-23.2023.DOI: 10.1523/ENEURO.0263-23.2023
PMID: 37903619
PMCID: PMC10668224
Date of Paper: 16/11/2023
Division: NeurobiologyLin Z., Green E. W., Webster S. G., Hastings M. H., Wilcockson D. C., Kyriacou C. P.
The circadian clock gene bmal1 is necessary for co-ordinated circatidal rhythms in the marine isopod Eurydice pulchra (Leach)
Plos Genetics 19(11):e1011047DOI: 10.1371/journal.pgen.1011047
PMID: 37967082
PMCID: PMC10651029
Date of Paper: 15/11/2023
Division: NeurobiologyDickerson J. L., Leahy E., Peet M. J., Naydenova K., Russo C. J.
Accurate magnification determination for cryoEM using gold
Ultramicroscopy 256:113883DOI: 10.1016/j.ultramic.2023.113883
PMID: 38008055
PMCID: PMC10782223
Date of Paper: 15/11/2023
Division: Structural StudiesKasaragod V. B., Malinauskas T., Wahid A. A., Lengyel J., Knoflach F., Hardwick S. W., Jones C. F., Chen W. N., Lucas X., El Omari K., Chirgadze D. Y., Aricescu A. R., Cecere G., Hernandez M. C., Miller P. S.
The molecular basis of drug selectivity for α5 subunit-containing GABA(A) receptors
Nature Structural & Molecular Biology 30(12): 1936–1946.DOI: 10.1038/s41594-023-01133-1
PMID: 37903907
PMCID: PMC10716045
Date of Paper: 30/10/2023
Division: NeurobiologyMadan V., Albacete-Albacete L., Jin L., Scaturro P., Watson J. L., Muschalik N., Begum F., Boulanger J., Bauer K., Kiebler M. A., Derivery E., Bullock S. L
HEATR5B associates with dynein-dynactin and promotes motility of AP1-bound endosomal membranes
The EMBO Journal 42(23):e114473DOI: 10.15252/embj.2023114473
PMID: 37872872
PMCID: PMC10690479
Date of Paper: 24/10/2023
Division: Cell BiologyCanon L., Kikuti C., Planelles-Herrero V. J., Lin T., Mayeux F., Sirkia H., Lee Y. I., Heidsieck L., Velikovsky L., David A., Liu X., Moussaoui D., Forest E., Höök P., Petersen K. J., Morgan T. E., Di Cicco A., Sirés-Campos J., Derivery E., Lévy D., Delevoye C., Sweeney H. L., Houdusse A.
How myosin VI traps its off-state, is activated and dimerizes
Nature Communications 14(1):6732DOI: 10.1038/s41467-023-42376-2
PMID: 37872146
PMCID: PMC10593786
Date of Paper: 23/10/2023
Division: Cell BiologyWatson JL, Seinkmane E, Styles CT, Mihut A, Krüger LK, McNally KE, Planelles-Herrero VJ, Dudek M, McCall PM, Barbiero S, Vanden Oever M, Peak-Chew SY, Porebski BT, Zeng A, Rzechorzek NM, Wong DCS, Beale AD, Stangherlin A, Riggi M, Iwasa J, Morf J, Miliotis C, Guna A, Inglis AJ, Brugués J, Voorhees RM, Chambers JE, Meng QJ, O'Neill JS, Edgar RS, Derivery E.
Macromolecular condensation buffers intracellular water potential
Nature 623(7988):842-852DOI: 10.1038/s41586-023-06626-z
PMID: 37853127
PMCID: PMC10665201
Date of Paper: 18/10/2023
Division: Cell BiologySanford S. A. I., Miller L. V. C, Vaysburd M., Keeling S., Tuck B. J., Clark J., Neumann M., Syanda V., James L. C., McEwan W. A.
The type-I interferon response potentiates seeded tau aggregation and exacerbates tau pathology
Alzheimer's & Dementia : the Journal of the Alzheimer's AssociationDOI: 10.1002/alz.13493
PMID: 37849026
PMCID:
Date of Paper: 17/10/2023
Division: Protein & Nucleic Acid ChemistryPorebski B. T., Balmforth M., Browne G. Riley A., Jamali K., Fürst M. J. L.J., Velic M., Buchanan A., Minter R., Vaughan T, Holliger P.
Rapid discovery of high-affinity antibodies via massively parallel sequencing, ribosome display and affinity screening
Nature Biomedical EngineeringDOI: 10.1038/s41551-023-01093-3
PMID: 37814006
PMCID:
Date of Paper: 09/10/2023
Division: Protein & Nucleic Acid ChemistrySchweighauser M., Murzin A. G., Macdonald J., Lavenir I., Crowther R. A., Scheres S. H. W., Goedert M.
Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau
Acta Neuropathologica Communications 11(1):160DOI: 10.1186/s40478-023-01658-y
PMID: 37798679
PMCID: PMC10552433
Date of Paper: 05/10/2023
Division: Structural StudiesZaiss D. M. W., Pearce E. J., Artis D., McKenzie A. N. J., Klose C. S. N.
Cooperation of ILC2s and T(H)2 cells in the expulsion of intestinal helminth parasites
Nature reviews. ImmunologyDOI: 10.1038/s41577-023-00942-1
PMID: 37798539
PMCID:
Date of Paper: 05/10/2023
Division: Protein & Nucleic Acid ChemistryWilliams S. L, Casas-Delucchi C. S., Raguseo F., Guneri D., Li Y., Minamino M., Fletcher E. E., Yeeles J. T., Keyser U. F, Waller Z. A., Di Antonio M., Coster G.
Replication-induced DNA secondary structures drive fork uncoupling and breakage
The EMBO Journal 42(22):e114334DOI: 10.15252/embj.2023114334
PMID: 37781931
PMCID: PMC10646557
Date of Paper: 02/10/2023
Division: Protein & Nucleic Acid ChemistryWilliams S. L., Casas-Delucchi C. S., Raguseo F., Guneri D., Li Y., Minamino M., Fletcher E. E., Yeeles JT ., Keyser U. F., Waller Z. A., Di Antonio M., Coster G.
Replication-induced DNA secondary structures drive fork uncoupling and breakage
The EMBO Journal 42(22):e114334DOI: 10.15252/embj.2023114334
PMID: 37781931
PMCID: PMC10646557
Date of Paper: 02/10/2023
Division: Protein & Nucleic Acid ChemistryChiaradia I., Imaz-Rosshandler I., Nilges B. S., Boulanger J., Pellegrini L., Das R., Kashikar N. D., Lancaster M. A.
Tissue morphology influences the temporal program of human brain organoid development
Cell Stem Cell 30(10):1351-1367.e10DOI: 10.1016/j.stem.2023.09.003
PMID: 37802039
PMCID:
Date of Paper: 01/10/2023
Division: Cell BiologyWatson J. L., Krüger L. K., Ben-Sasson A. J., Bittleston A., Shahbazi M. N., Planelles-Herrero V. J., Chambers J. E., Manton J. D., Baker D., Derivery E.
Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells
Cell 186(21):4710-4727.e35DOI: 10.1016/j.cell.2023.08.034
PMID: 37774705
PMCID:
Date of Paper: 28/09/2023
Division: Cell BiologyLi Z, Shang Z, Liu J, Zhen H, Zhu E, Zhong S, Sturgess RN, Zhou Y, Hu X, Zhao X, Wu Y, Li P, Lin R, Ren J.
D-LMBmap: a fully automated deep-learning pipeline for whole-brain profiling of neural circuitry
Nature Methods 20(10):1593-1604DOI: 10.1038/s41592-023-01998-6
PMID: 37770711
PMCID: PMC10555838
Date of Paper: 28/09/2023
Division: NeurobiologyBasu S, Shukron O, Hall D, Parutto P, Ponjavic A, Shah D, Boucher W, Lando D, Zhang W, Reynolds N, Sober LH, Jartseva A, Ragheb R, Ma X, Cramard J, Floyd R, Balmer J, Drury TA, Carr AR, Needham LM, Aubert A, Communie G, Gor K, Steindel M, Morey L, Blanco E, Bartke T, Di Croce L, Berger I, Schaffitzel C, Lee SF, Stevens TJ, Klenerman D, Hendrich BD, Holcman D, Laue ED.
Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD
Nature Structural & Molecular Biology 30(11):1628-1639DOI: 10.1038/s41594-023-01095-4
PMID: 37770717
PMCID: PMC10643137
Date of Paper: 28/09/2023
Division: Cell BiologyScheres S. H. W., Ryskeldi-Falcon B., Goedert M.
Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids
Nature 621(7980):701-710DOI: 10.1038/s41586-023-06437-2
PMID: 37758888
PMCID:
Date of Paper: 27/09/2023
Division: NeurobiologyHowes A. C., Perisic O., Williams R. L.
Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress
Science Advances 9(39):eadi8291DOI: 10.1126/sciadv.adi8291
PMID: 37756394
PMCID: PMC10530080
Date of Paper: 27/09/2023
Division: Protein & Nucleic Acid ChemistryXia Y., Sonneville R., Jenkyn-Bedford M., Ji L, Alabert C., Hong Y., Yeeles J. T. P., Labib K. P. M.
DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans
Science 381(6664):eadi4932DOI: 10.1126/science.adi4932
PMID: 37590372
PMCID: PMC7615117
Date of Paper: 22/09/2023
Division: Protein & Nucleic Acid ChemistryForsberg B. O., Shah P. N. M., Burt A.
A robust normalized local filter to estimate compositional heterogeneity directly from cryo-EM maps
Nature Communications 14(1):5802DOI: 10.1038/s41467-023-41478-1
PMID: 37726277
PMCID: PMC10509264
Date of Paper: 19/09/2023
Division: Structural StudiesKhedoe P. P. S. J., van Schadewijk W. A. A. M., Schwiening M., Ng-Blichtfeldt J. P., Marciniak S. J., Stolk J., Gosens R., Hiemstra P. S.
Cigarette smoke restricts the ability of mesenchymal cells to support lung epithelial organoid formation
Frontiers in Cell and Developmental Biology 11:1165581DOI: 10.3389/fcell.2023.1165581
PMID: 37795260
PMCID: PMC10546195
Date of Paper: 19/09/2023
Division: Cell BiologyGupta D., Orehek S., Turunen J., O'Donovan L., Gait M. J, El-Andaloussi S., Wood M. J. A.
Modulation of Pro-Inflammatory IL-6 Trans-Signaling Axis by Splice Switching Oligonucleotides as a Therapeutic Modality in Inflammation
Cells 12(18):2285DOI: 10.3390/cells12182285
PMID: 37759507
PMCID: PMC10526877
Date of Paper: 15/09/2023
Division: Protein & Nucleic Acid Chemistry