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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Home > First structure of human telomerase in dimeric assembly

First structure of human telomerase in dimeric assembly

First structure of human telomerase in dimeric assembly

Published on 11 July, 2025

Kelly Nguyen’s group, in the LMB’s Structural Studies Division, have used cryo-EM to visualise telomerase in a dimeric formation for the first time and demonstrated how dimerization is important for telomere maintenance.

How RECQL5 applies the brakes to speeding RNA polymerase II to safeguard genome stability

Published on 7 July, 2025

Suyang Zhang’s group, in the LMB’s Structural Studies Division, has elucidated how the DNA helicase RECQL5 works with the transcription-coupled DNA repair complex to brake and accelerate RNA polymerase II transcription to maintain genome stability.

Alan Fersht and Wes Robertson discuss the past, present and future of protein studies

Published on 4 July, 2025

The Naked Scientists podcast covers all things protein, including speaking to Alan Fersht and Wes Robertson from the LMB’s PNAC Division. They cover how early advances at the LMB revolutionised the field of protein studies, and how protein design could be developed to address key concerns in health and the environment. More…

Juliette Fedry is a Finalist in Eppendorf Award for Young European Investigators

Published on 4 July, 2025

Juliette Fedry, Group Leader in the LMB’s Cell Biology Division, has been recognised for her research into cellular proteostasis processes in health and disease.

Matt Higgins and Clemens Plaschka elected to EMBO Membership

Published on 2 July, 2025

Higgins: LMB 1997-2007, PhD student; Postdoctoral Scientist, Neurobiology; Structural StudiesPlaschka: LMB 2016-2018, Postdoctoral Visitor and Scientist, Structural Studies Congratulations to alumni Matt Higgins and Clemens Plaschka who have both been elected to EMBO Membership. Matt now leads a research group at the Department of Biochemistry, University of Oxford and Clemens is a Senior Group Leader […]

Architecture of the disease-prone GluA3 receptor unlocks new avenues for drug design

Published on 1 July, 2025

Ingo Greger’s group, in the LMB’s Neurobiology Division, discover that the GluA3 AMPAR adopts a structural organization that substantially diverges from all the other AMPA receptors.

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